Patents Assigned to Biogal Gyogyszergyar Rt.
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Publication number: 20050119281Abstract: The present invention provides a powder composition comprising zaleplon of defined particle size distribution. The zaleplon of defined particle size can be formulated into a wide variety of pharmaceutical compositions and dosage forms.Type: ApplicationFiled: February 19, 2003Publication date: June 2, 2005Applicant: Biogal Gyogyszergyar RtInventors: Erika Feher, Ferenc Korodi, Claude Singer, Czaba Szabo, Judith Aronhime, Sheldon Deck
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Patent number: 6861557Abstract: The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone}]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof.Type: GrantFiled: March 8, 2004Date of Patent: March 1, 2005Assignee: Biogal Gyógyszergyár Rt.Inventors: Ben-Zion Dolitzky, Ofer Reany, Jenny Shammai
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Patent number: 6858414Abstract: The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted into its mesylate salt substantially free of the other polyhydroxamates and substantially free of chloride ion. The process includes adsorption and desorption of the deferoxamine B on an adsorption resin, direct precipitation of the deferoxamine free base out of the eluent from the adsorption resin, contacting of the deferoxamine B free base with methanesulfonic acid and isolation of the deferoxamine B mesylate salt by precipitation. This process minimizes decomposition of deferoxamine B.Type: GrantFiled: November 30, 2000Date of Patent: February 22, 2005Assignee: Biogal Gyógyszergyár Rt.Inventors: Vilmos Keri, Zoltan Czovek, Attila Mezo
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Patent number: 6852861Abstract: The invention provides 1H-imidazo(4,5-C)quinolin-4-phthalimide intermediates useful in the synthesis of 1H-imidazo(4,5-C)quinoline-4-amines, particularly Imiquimod. The invention further provides a method for making the intermediates and a method for making 1H-imidazo(4,5-C)quinoline-4-amines via the intermediates.Type: GrantFiled: July 23, 2003Date of Patent: February 8, 2005Assignee: Biogal Gyogyszergyar Rt.Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
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Patent number: 6852858Abstract: Zaleplon can be separated from a regioisomer impurity by crystallization from selected solvents or by adding an anti-solvent to a solution of zaleplon and the regioisomer. Zaleplon crystalline Forms II, III, IV, and V are useful for the treatment of insomnia. These crystalline Forms are described along with processes for making them v crystallization from selected solvents.Type: GrantFiled: August 1, 2002Date of Patent: February 8, 2005Assignee: Biogal Gyogyszergyar Rt.Inventors: Erika Feher, Ferenc Korodi, Claude Singer, Erika Magyar
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Patent number: 6849763Abstract: The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone)]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof.Type: GrantFiled: March 8, 2004Date of Patent: February 1, 2005Assignee: Biogal Gyógyszergyár Rt.Inventors: Ben-Zion Dolitzky, Ofer Reany, Jenny Shammai
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Patent number: 6844174Abstract: The present invention provides a fermentation process for producing lipstatin comprising the steps of: a) preparing a fermentation medium containing a lipstatin-producing microorganism comprising an oil and an assimilable carbon source, wherein the wt/wt ratio of oil and assimilable carbon source is regulated to achieve an optimal lipstatin biosynthesis by the microorganism; and b) feeding the fermentation medium with an emulsifier, wherein the emulsifier provides an optimal viscosity for the fermentation medium and optimal pH during the fermentation to permit fermentation for lipstatin production. The disclosed process also provides a process for extracting a lipstatin from a fermentation broth.Type: GrantFiled: December 4, 2002Date of Patent: January 18, 2005Assignee: Biogal Gyogyszergyar Rt.Inventors: Janos Erdei, Eva Gulyas, Gabor Balogh, Laszlo Toth, Vilmos Keri, Andrea Csorvasi
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Patent number: 6841678Abstract: The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C] quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C] quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-carboxamide, and to the said intermediates.Type: GrantFiled: July 28, 2003Date of Patent: January 11, 2005Assignee: Biogal Gyogyszergyar Rt.Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
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Patent number: 6797843Abstract: The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone}]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof.Type: GrantFiled: September 22, 2003Date of Patent: September 28, 2004Assignee: Biogal Gyógyszergyár Rt.Inventors: Ben-Zion Dolitzky, Ofer Reany, Jenny Shammai
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Patent number: 6734314Abstract: The present invention is directed to a process of converting lipstatin to orlistat by catalytic hydrogenation. The present invention further discloses novel crystalline solid orlistat forms, designated form I and form II and methods for their preparation.Type: GrantFiled: December 4, 2002Date of Patent: May 11, 2004Assignee: Biogal Gyogyszergyar Rt.Inventors: Vilmos Keri, Andrea Csorvasi, Judith Aronhime
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Patent number: 6706192Abstract: Object of the invention is a process for the chromatographic purification of cyclosporin A from a crude product containing cyclosporin complex by using a column filled with silica gel and by the application of multistep chromatography with a column filled with normal phase silica gel and by a solvent mixture containing toluene as the major component.Type: GrantFiled: May 15, 2002Date of Patent: March 16, 2004Assignee: Biogal Gyogyszergyar Rt.Inventors: Vilmos Kéri, Ärvai Nagyné, Lajos Deák, Györgyné Makó, Istvánné Miskolczy
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Patent number: 6689590Abstract: A composition comprising pravastatin sodium substantially free of pravastatin lactone is described.Type: GrantFiled: July 23, 2002Date of Patent: February 10, 2004Assignee: Biogal Gyogyszergyar Rt.Inventors: Vilmos Keri, Lajos Deak, Iiona Forgacs, Csaba Szabo, Edit Arvai Nagyne
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Patent number: 6521762Abstract: A process reducing the levels of dimeric impurities in a statin to less than 0.08% by treatment of a statin containing more than 0.08% dimeric impurities with a mild base in a suitable solvent mixture.Type: GrantFiled: February 27, 2001Date of Patent: February 18, 2003Assignee: Biogal Gyógyszergyar Rt.Inventors: Vilmos Keri, Ilona Forgas
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Patent number: 6509177Abstract: A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20° C. and 30° C. containing organic nitrogen and carbon sources and, optionally, mineral salts.Type: GrantFiled: February 3, 2000Date of Patent: January 21, 2003Assignee: Biogal Gyogyszergyar Rt.Inventors: Valeria Szell, Ildiko Lang, Istvan Barta, Aniko Tedges, Karoly Albrecht, Julianna Mozes Nee Suto, Istvan M. Szabo, Magdolna Petroczki, Janos Erdei, Eva Gulyas, Gabor Balogh
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Patent number: 6506591Abstract: A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20° C. and 30° C. containing organic nitrogen and carbon sources and, optionally, mineral salts.Type: GrantFiled: October 11, 2001Date of Patent: January 14, 2003Assignee: Biogal Gyogyszergyar Rt.Inventors: Valeria Szell, Ildiko Lang, Istvan Barta, Aniko Tedges, Karoly Albrecht, Julianna Mozes Nee Suto, Istvan M. Szabo, Magdolna Petroczki, Janos Erdei, Eva Gulyas, Gabor Balogh
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Patent number: 6500651Abstract: A method for producing mevinolin by a microorganism in a fermentation process having a seed culture stage and a main fermentation stage, including a) cultivating a microorganism biomass in the seed culture stage to produce an inoculum; b) transferring the inoculum into a fermentation medium in the main fermentation stage; and, c) maintaining steady stage conditions in the main fermentation stage, thereby producing a fermentation broth containing mevinolin. Preferably, the steady state conditions are maintained in the main fermentation stage by one or more of feeding of organic carbon sources; controlling glucose and/or total reducing sugar content; feeding of organic nitrogen sources; controlling pH; controlling foam level; controlling the mass of the fermentation broth by withdrawals and feedings; and, controlling the dissolved oxygen level.Type: GrantFiled: April 5, 2000Date of Patent: December 31, 2002Assignee: Biogal Gyogyszergyar Rt.Inventors: Péter Seress, Gábor Balogh, Antal Oláh, László Cséke
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Patent number: 6444452Abstract: A novel process for recovering a compound from a fermentation broth that includes the stages of forming an enriched solution of the compound by extraction, obtaining a salt of the compound from the enriched solution, purifying a salt of the compound and trans-salifying the salt of the compound to a metal salt of the compound is disclosed.Type: GrantFiled: November 28, 2000Date of Patent: September 3, 2002Assignee: Biogal Gyogyszergyar Rt.Inventors: Vilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Edit Arvai Nagyne
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Patent number: 6423233Abstract: Object of the invention is a process for the chromatographic purification of cyclosporin A from a crude product containing cyclosporin complex by using a column filled with silica gel and by the application of multistep chromatography with a column filled with normal phase silica gel and by a solvent mixture containing toluene as the major component.Type: GrantFiled: August 15, 2000Date of Patent: July 23, 2002Assignee: Biogal Gyogyszergyar Rt.Inventors: Vilmos Kéri, Árvai Edit Nagyné, Lajos Deák, Györgyné Makó, Istvánné Miskolczy
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Patent number: 6387258Abstract: A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin compound is extracted under acidic conditions into a hydrophobic solvent and purified by crystallization. The organic extraction solvent is concentrated and then extracted with a mild base. The statin compound is then purified by crystallization.Type: GrantFiled: January 25, 2001Date of Patent: May 14, 2002Assignee: Biogal Gyogyszergyar Rt.Inventors: Vilmos Keri, Lajos Deak, Iiona Forgacs
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Patent number: 6245921Abstract: A process for the isolation of the pseudomonic acid A antibiotic of pharmaceutical quality from the culture broth of one of the pseudomonic acid A-producing species of the Pseudomonas bacterium genus comprising the extraction of the biosynthesized pseudomonic acid A from the culture broth at acidic pH with a chlorinated aliphatic hydrocarbon or isobutyl acetate, followed by purification, is disclosed.Type: GrantFiled: February 3, 2000Date of Patent: June 12, 2001Assignee: Biogal Gyogyszergyar Rt.Inventors: Istvan Barta, Aniko Tegdes, Valeria Szell, Csaba Szabo, Edit Nagy Nee Arvai, Vilmos Keri, David Leonov, IIdiko Lang, Margit Bidlo Nee Igloy, Gyula Jerkovich, Janos Salat