Abstract: The endogenous enhancement of neurotensin, an endogenous tridecapeptide, has anti-diabetic, anti-inflammatory, anti-psychotic, neuroleptic and analgesic activity. Exogenous administration of neurotensin causes several side effects. The present invention provides electrical stimulation to increase endogenous neurotensin levels, which provides the benefits of neurotensin without eliciting the unwanted side effects.

Abstract: An improved compact transcutaneous electrical nerve stimulator (TENS) is provided. The compact TENS of the present invention may be used as a therapeutic device for the reduction of the symptoms of chronic and acute pain. The TENS device includes a power supply and electronics which are packaged to provide a compact, light-weight device which may be worn for an extended period of time by a patient requiring pain relief. Electronic circuitry in the TENS generates an output signal in the form of a positive spike waveform followed by a negative longer duration, lower voltage, waveform. The TENS output signal includes a broad range of frequency components, extending into the gigahertz range. Signal conditioning potentiometers are provided for adjustment of the maximum TENS output signal amplitude. Multiple output channel operation may be provided.