Patents Assigned to Biognostik Gesellschaft fur biomolekulare Diagnostik mbH
  • Mixture comprising an inhibitor or suppressor of a gene and a molecule binding to an expression product of that gene
    Patent number: 8703729
    Abstract: A mixture comprising at least one inhibitor or suppressor of the expression of a gene and at least one molecule binding to an expression product of said gene.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: April 22, 2014
    Assignee: Biognostik Gesellschaft fur Biomolekulare Diagnostik mbH
    Inventors: Karl-Hermann Schlingensiepen, Reimar Schlingensiepen
  • Method for stimulating the immune system
    Patent number: 8629117
    Abstract: Medicament comprising a combination of at least one inhibitor of the effect of a substance negatively effecting an immune response, the substance selected from the group consisting of TGF-? and its receptors, VEGF and its receptors, interleukin 10 (IL-10) and its receptors, PGE2 and its receptors, wherein the inhibitor has a molecular weight of less than 100 kDa and at least one stimulator positively effecting an immune response.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: January 14, 2014
    Assignee: Biognostik Gesellschaft fur biomolekulare Diagnostik mbH
    Inventors: Karl-Hermann Schlingensiepen, Reimar Schlingensiepen, Wolfgang Brysch
  • Antisense-oligonucleotides for the treatment of immuno-suppressive effects of transforming growth factor-? (TGF-?)
    Patent number: 7667027
    Abstract: Antisense-oligonucleotides or effective derivatives thereof hybridizing with an area of a gene coding for transforming growth factor-? (TGF-?) comprising the following nucleic acid sequences identified in the sequence listing under SEQ ID NO. 1-56 and 137 or comprising the following nucleic acid sequences identified in the sequence listing under SEQ ID NO. 57 to 136 each of the nucleic acids having a DNA- or RNA-type structure.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: February 23, 2010
    Assignee: Biognostik Gesellschaft Fur Biomolekulare Diagnostik mbH
    Inventors: Georg-Ferdinand Schlingensiepen, Wolfgang Brysch, Karl-Hermann Schlingensiepen, Reimar Schlingensiepen, Ulrich Bogdahn
  • Pharmaceutical composition comprising antisense-nucleic acid for prevention and/or treatment of neuronal injury, degeneration and cell death and for the treatment of neoplasms
    Patent number: 7326783
    Abstract: A pharmaceutical composition comprising an effective amount of a compound which is capable from preventing and treating neuronal injury, degeneration, cell death and/or neoplasms in which expression of c-jun, c-fos or jun-B plays a causal role which compound being an antisense nucleic acid or effective derivative thereof, said antisense nucleic acid hybridizing with an area of the messenger RNA (mRNA) and/or DNA encoding c-jun, c-fos or jun-B.
    Type: Grant
    Filed: July 6, 1994
    Date of Patent: February 5, 2008
    Assignee: Biognostik Gesellschaft fur biomolekulare Diagnostik mbH
    Inventors: Georg-F Schlingensiepen, Reimar Schlingensiepen, Karl-Hermann Schlingensiepen, Wolfgang Brysch
  • Antisense-oligonucleotides for the treatment of immuno-suppressive effects of transforming growth factor-beta (TGF-beta)
    Publication number: 20030040499
    Abstract: Antisense-oligonucleotides or effective derivatives thereof hybridizing with an area of a gene coding for transforming growth factor-&bgr; (TGF-&bgr;) comprising the following nucleic acid sequences identified in the sequence listing under SEQ ID NO. 1-56 and 137 or comprising the following nucleic acid sequences identified in the sequence listing under SEQ ID NO. 57 to 136 each of the nucleic acids having a DNA- or RNA-type structure.
    Type: Application
    Filed: May 16, 2002
    Publication date: February 27, 2003
    Applicant: Biognostik Gesellschaft Fur Biomolekulare Diagnostik mbH
    Inventors: Georg-Fredinand Sclingensiepen, Wolfgang Brysch, Karl-Hermann Schlingensiepen, Reimar Schlingensiepen, Ulrich Bogdahn
  • Antisense-oligonucleotides for transforming growth factor-&bgr; (TGF-&bgr;)
    Patent number: 6455689
    Abstract: Antisense-oligonucleotides or effective derivatives thereof hybridizing with an area of a gene coding for transforming growth factor-&bgr; (TGF-&bgr;) comprising the following nucleic acid sequences identified in the sequence listing under SEQ ID NO. 1-56 and 137 or comprising the following nucleic acid sequences identified in the sequence listing under SEQ ID NO. 57 to 136 each of the nucleic acids having a DNA- or RNA-type structure.
    Type: Grant
    Filed: October 30, 1995
    Date of Patent: September 24, 2002
    Assignee: Biognostik Gesellschaft für Biomolekulare Diagnostik mbH
    Inventors: Georg-Ferdinand Schlingensiepen, Wolfgang Brysch, Karl-Hermann Schlingensiepen, Reimar Schlingensiepen, Ulrich Bogdahn