Patents Assigned to Biohit Oyj
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Publication number: 20200072852Abstract: According to an example aspect of the present invention, there is provided an improved method for screening of asymptomatic and symptomatic subjects with Helicobacter pylori infection, atrophic gastritis with related risks and/or disturbed gastric function based on whole blood samples, sample collection time and sample storage temperature, as well as relevant biomarker content analysis.Type: ApplicationFiled: November 14, 2016Publication date: March 5, 2020Applicant: BIOHIT OYJInventor: Osmo SUOVANIEMI
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Patent number: 10092534Abstract: The present invention concerns a non-toxic solid pharmaceutical composition for oral administration, containing one or more cysteine compounds from the group of L-cysteine, D-cysteine and N-acetyl cysteine, combined with one or more additional active agents, at least one of which being selected from cystine, glutathione and methionine, the composition further containing one or more pharmaceutical additives. Further, the invention concerns a method for reducing the incidence of severe headaches, particularly migraine and/or cluster headaches.Type: GrantFiled: May 28, 2013Date of Patent: October 9, 2018Assignee: BIOHIT OYJInventor: Osmo Suovaniemi
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Publication number: 20170252312Abstract: The present invention relates to a cysteine releasing pharmaceutical preparation(s) for novel use in preventing and/or treating alcohol flushing and alcohol induced hypersensitivity reactions. Additionally, the invention relates to a method for eliminating histamine releasing effect of locally formed acetaldehyde in the digestive tract.Type: ApplicationFiled: September 15, 2015Publication date: September 7, 2017Applicant: BIOHIT OYJInventors: Semi KORPELA, Kari SYRJANEN, Mikko SALASPURO, Osmo SUOVANIEMI
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Patent number: 9474733Abstract: The object of the invention is the use of compounds comprising one or more free sulphlydryl or amino groups for preparing a pharmaceutical composition for locally binding acetaldehyde in saliva, the stomach or the large intestine, and pharmaceutical compositions comprising the said compounds.Type: GrantFiled: October 30, 2001Date of Patent: October 25, 2016Assignee: BIOHIT OYJInventors: Mikko Salaspuro, Martti Marvola
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Patent number: 9285373Abstract: The present invention relates to a method for examining a person having symptoms and/or biomarkers indicating an autoimmune disease for the presence of atrophic gastritis. The biomarker combination, which diagnoses atrophic gastritis, acts also as a part of a biomarker panel that helps diagnosis and assessment of autoimmune disease as well. The invention relates also to products used in these methods.Type: GrantFiled: April 23, 2010Date of Patent: March 15, 2016Assignee: BIOHIT OYJInventor: Osmo Suovaniemi
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Publication number: 20160022621Abstract: The present invention relates to a non-toxic composition containing one or more cysteine compounds selected from L- or D-cysteine, N-acetyl cysteine, and the pharmaceutically acceptable salts thereof, for decreasing the risk of a subject contracting cancer of the stomach, the small intestine and the colon, by locally binding aldehydes present in the stomach, and optionally also separately the aldehydes carried to the small intestine or the colon, or both, whereby the composition is formulated with the help of two or more additives into controlled-release tablets containing at least one additive selected from cationic and gel-forming polymers, which tablets are formed from two or more separate layers with different release profiles, whereby the cysteine compounds are added both into the inner layer(s) and into the tablet material surrounding these.Type: ApplicationFiled: March 12, 2013Publication date: January 28, 2016Applicant: BIOHIT OYJInventor: Osmo SUOVANIEMI
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Publication number: 20160022620Abstract: The present invention relates to non-toxic composition containing, as active compounds, one or more aldehyde-binding compounds, such as L- or D-cysteine, N-acetyl cysteine, and the pharmaceutically acceptable salts thereof, and optionally one or more further active compounds selected from sulphites and xylitol, the composition being used for decreasing the risk of a subject contracting cancer of the stomach, and indirectly of the small intestine and the large intestine. The composition is formulated into a controlled-release formulation consisting of granules contained in a capsule.Type: ApplicationFiled: March 12, 2013Publication date: January 28, 2016Applicant: BIOHIT OYJInventor: Osmo SUOVANIEMI
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Publication number: 20150132275Abstract: The present invention concerns a non-toxic solid pharmaceutical composition for oral administration, containing one or more cysteine compounds from the group of L-cysteine, D-cysteine and N-acetyl cysteine, combined with one or more additional active agents, at least one of which being selected from cystine, glutathione and methionine, the composition further containing one or more pharmaceutical additives. Further, the invention concerns a method for reducing the incidence of severe headaches, particularly migraine and/or cluster headaches.Type: ApplicationFiled: May 28, 2013Publication date: May 14, 2015Applicant: BIOHIT OYJInventor: Osmo Suovaniemi
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Patent number: 8758812Abstract: This invention relates to a non-toxic composition which bind acetaldehyde present in the stomach, intestine and/or colon. The composition comprises one or more acetaldehyde-binding compound(s) comprising one or more free sulphhydryl and/or amino groups. The compound(s) are mixed with a non-toxic carrier that effects sustained release of said compound(s) in the gastrointestinal tract. This invention relates also to food additives and food compositions and packages comprising the composition.Type: GrantFiled: May 22, 2007Date of Patent: June 24, 2014Assignee: Biohit OyjInventors: Osmo Suovaniemi, Ville Salaspuro, Martti Marvola, Mikko Salaspuro
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Publication number: 20140128336Abstract: The present invention concerns products, such as compositions or medical devices, comprising one or more compounds of the Formula I, containing one or more free sulphhydryl groups, where R1 is hydrogen or an acetyl group, and R2 is a sulphhydryl group or a C1-C5 straight chained or branched hydrocarbon chain, optionally containing one or more heteroatoms selected from O, N and S, further containing one or more free sulphhydryl groups, for use in connection with Helicobacter pylori infections or other related infections, either as such or as combinations with antibiotics, whereby the compound(s) and optionally, when present, the antibiotic(s), are mixed with one or more pharmaceutically acceptable carriers providing sustained local release in the stomach or elsewhere in the upper aerodigestive tract.Type: ApplicationFiled: April 18, 2012Publication date: May 8, 2014Applicant: BIOHIT OYJInventors: Matti Härkönen, Tuuli Marvola, Mikko Salaspuro, Osmo Suovaniemi
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Patent number: 8227513Abstract: The object of the invention comprises food compositions, to which one or more acetaldehyde-binding compounds are added. The purpose of the compositions is to reduce the amount of detrimental acetaldehyde in the area of the mouth, the pharynx, the oesophagus, the stomach, and the small and large intestines, and through this, to reduce the risk of developing cancers in these areas.Type: GrantFiled: November 19, 2009Date of Patent: July 24, 2012Assignee: Biohit OyjInventors: Osmo Suovaniemi, Mikko Salaspuro, Ville Salaspuro, Martti Marvola
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Patent number: 8141410Abstract: The invention is directed to a method for testing batches of tips for pipettes, the method comprising the steps of calibrating a pipette to be tested with a recommended reference tip, fitting the pipette with a tip to be tested and performing a second calibration and recalibrating the pipette with the reference tip.Type: GrantFiled: August 10, 2007Date of Patent: March 27, 2012Assignee: Biohit OyjInventor: Ian Hemmings
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Patent number: 8117928Abstract: This invention relates to a method for selecting a plunger-cylinder tip of a pipette and a device for carrying out the method. In the method, the dose size is entered into the control electronics of the pipetting device; the dose size is stored in the control electronics; the amount of doses is entered; and on the basis of the dose size and the amount of doses, the control electronics indicates suitable available interchangeable components on the display.Type: GrantFiled: April 25, 2007Date of Patent: February 21, 2012Assignee: Biohit OyjInventors: Osmo Suovaniemi, Erkki Vesanen
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Publication number: 20110171296Abstract: The object of the invention is the use of compounds comprising one or more free sulphhydryl or amino groups for preparing a pharmaceutical composition for locally binding acetaldehyde in saliva, the stomach or the large intestine, and pharmaceutical compositions comprising the said compounds.Type: ApplicationFiled: January 11, 2011Publication date: July 14, 2011Applicant: Biohit OyjInventors: Mikko Salaspuro, Martti Marvola
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Publication number: 20110033560Abstract: The present invention relates to the use of a preparation comprising a substance that is capable of binding acetaldehyde, and to the use of a filter that is attached to a tobacco product to reduce tobacco and/or alcohol dependence.Type: ApplicationFiled: September 12, 2008Publication date: February 10, 2011Applicant: BIOHIT OYJInventors: Osmo Suovaniemi, Mikko Salaspuro, Ville Salaspuro, Martti Marvola
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Publication number: 20100239663Abstract: This invention relates to a non-toxic composition which bind acetaldehyde present in the stomach, intestine and/or colon. The composition comprises one or more acetaldehyde-binding compound(s) comprising one or more free sulphhydryl and/or amino groups. The compound(s) are mixed with a non-toxic carrier that effects sustained release of said compound(s) in the gastrointestinal tract. This invention relates also to food additives and food compositions and packages comprising the composition.Type: ApplicationFiled: May 22, 2007Publication date: September 23, 2010Applicant: BIOHIT OYJInventors: Osmo Suovaniemi, Ville Salaspuro, Martti Marvola, Mikko Salaspuro
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Publication number: 20100206318Abstract: The invention relates to a cigarette holder-type component, which is intended to be attached to a tobacco product and can be adapted to the suction head of the tobacco product so that the smoke travels through the component during smoking. The component contains porous material, into which an aqueous solution containing at least one aldehyde-binding compound has been absorbed to form an aldehyde-binding filter. In the component that is to be attached to the tobacco product, the water content of the material is kept at a level where the aldehyde-binding compounds are capable of reacting with the aldehydes in the smoke, changing them into a harmless form.Type: ApplicationFiled: May 16, 2008Publication date: August 19, 2010Applicant: BIOHIT OYJInventors: Ville Salaspuro, Mikko Salaspuro, Osmo Suovaniemi
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Publication number: 20100063149Abstract: The object of the invention comprises food compositions, to which one or more acetaldehyde-binding compounds are added. The purpose of the compositions is to reduce the amount of detrimental acetaldehyde in the area of the mouth, the pharynx, the oesophagus, the stomach, and the small and large intestines, and through this, to reduce the risk of developing cancers in these areas.Type: ApplicationFiled: November 19, 2009Publication date: March 11, 2010Applicant: BIOHIT OYJInventors: Osmo SUOVANIEMI, Mikko Salaspuro, Ville Salaspuro, Martti Marvola
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Publication number: 20090320583Abstract: The invention is directed to a method for testing batches of tips for pipettes, the method comprising the steps of calibrating a pipette to be tested with a recommended reference tip, fitting the pipette with a tip to be tested and performing a second calibration and recalibrating the pipette with the reference tip.Type: ApplicationFiled: August 10, 2007Publication date: December 31, 2009Applicant: BIOHIT OYJInventor: Ian Hemmings
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Publication number: 20090253793Abstract: This invention relates to a non-toxic composition which bind acetaldehyde present in the stomach, intestine and/or colon. The composition comprises one or more acetaldehyde-binding compound(s) comprising one or more free sulphhydryl and/or amino groups. The compound(s) are mixed with a non-toxic carrier that effects sustained release of said compound(s) in the gastrointestinal tract. These compositions are of benefit in particular to patients having atrophic gastritis or achlorhydric or low acid stomach.Type: ApplicationFiled: May 22, 2007Publication date: October 8, 2009Applicant: Biohit OYJInventors: Osmo Suovaniemi, Ville Salaspuro, Martti Marvola, Mikko Salaspuro