Abstract: The invention covers a method of implanting a living donor cell into a host animal without inflammatory response or rejection of the donor cell by the host animal, by obtaining an uncoated particle of a biocompatible, temperature-independent gel that encapsulates the living donor cell, wherein the uncoated particle provides a molecular weight cutoff that prevents host animal immune cells from entering the particle, yet does not have to prevent entry of host animal IgG and complement into the particle, and implanting the uncoated particle into the host animal.
Type:
Grant
Filed:
November 19, 1996
Date of Patent:
June 15, 1999
Assignee:
BioHybrid Technologies, Inc.
Inventors:
Robert P. Lanza, Willem M. Kuhtreiber, William L. Chick
Abstract: Methods for inhibition of fibrotic rejection of implanted devices which contain cells by administering to the recipient of the devices an amount of a non-steroidal anti-inflammatory agent (NSAID) sufficient to inhibit fibrotic inactivation of the device. Most NSAID's are carboxylic acids (R--COOH) or enolic acids (R--COH).
Abstract: The invention covers a method of implanting a living donor cell into a host animal without inflammatory response or rejection of the donor cell by the host animal, by obtaining an uncoated particle of a biocompatible, temperature-independent gel that encapsulates the living donor cell, wherein the uncoated particle provides a molecular weight cutoff that prevents host animal immune cells from entering the particle, yet does not have to prevent entry of host animal IgG and complement into the particle, and implanting the uncoated particle into the host animal.
Type:
Grant
Filed:
April 15, 1994
Date of Patent:
July 29, 1997
Assignee:
Biohybrid Technologies, Inc.
Inventors:
Robert P. Lanza, Willem M. Kuhtreiber, William L. Chick