Abstract: The present invention relates to heterocyclic compounds of Formula I useful as anti-infective agents. The present invention further relates to a method of treating an infection by administering such compounds, and to pharmaceutical compositions comprising such compounds.
Type:
Grant
Filed:
June 22, 2017
Date of Patent:
September 28, 2021
Assignee:
Bioimics AB
Inventors:
Leif Kirsebom, Ram Shankar Upadhayaya, Raghava Reddy Kethiri, Anders Virtanen
Abstract: The present invention relates to a method for detection of novel pathogen inhibitors using models of pathogen specific, and metal binding structures/domains representing essential cellular molecules. The method enables identification of inhibitors that bind to any specific RNA molecule or protein that are essential for cell growth, proliferation and differentiation. The invention also relates to a kit for use in the method. Furthermore, the invention relates to use of aminoglycosides in the development of new drugs.