Patents Assigned to Bioinspire Technologies, Inc.
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Patent number: 10391204Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: July 21, 2017Date of Patent: August 27, 2019Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20190070342Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially nasal applications are provided, wherein the patch comprises a free-standing film containing at least one therapeutic agent selected from corticosteroids, antihistamines, monoclonal antibodies, leukotriene receptor antagonists, anti-inflammatory cytokines, vasoconstrictive agents, and any combination thereof. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and release the therapeutic content in a sustained fashion. The patch may be micronized and administered in a powdered form.Type: ApplicationFiled: November 2, 2018Publication date: March 7, 2019Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN, Arthur E. FERDINAND, Bradley CARR
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Patent number: 10159768Abstract: Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.Type: GrantFiled: June 15, 2017Date of Patent: December 25, 2018Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Kyle Hammerick
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Publication number: 20180200494Abstract: Systems and methods for the delivery of devices such as films to target locations in mammalian bodies are provided herein. The films may be configured to release a therapeutic agent over time, among other features. Delivery devices and methods described herein may be particularly well-suited for the delivery of therapeutic films to a target location in the sinuses.Type: ApplicationFiled: January 17, 2018Publication date: July 19, 2018Applicant: BioInspire Technologies, Inc.Inventors: Simon GATRALL, Celia L. CORRENTE, Jonathan P. DOWNING, Arthur E. FERDINAND
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Publication number: 20170319752Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: July 21, 2017Publication date: November 9, 2017Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN
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Publication number: 20170281833Abstract: Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.Type: ApplicationFiled: June 15, 2017Publication date: October 5, 2017Applicant: BioInspire Technologies, Inc.Inventors: Dorna HAKIMIMEHR, Kyle HAMMERICK
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Patent number: 9713658Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: September 15, 2016Date of Patent: July 25, 2017Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Patent number: 9682174Abstract: Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.Type: GrantFiled: February 17, 2016Date of Patent: June 20, 2017Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Kyle Hammerick
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Publication number: 20170000929Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: September 15, 2016Publication date: January 5, 2017Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN
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Patent number: 9446103Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: November 17, 2015Date of Patent: September 20, 2016Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20160158419Abstract: Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.Type: ApplicationFiled: February 17, 2016Publication date: June 9, 2016Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Kyle HAMMERICK
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Publication number: 20160067318Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: November 17, 2015Publication date: March 10, 2016Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN
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Patent number: 9271925Abstract: Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.Type: GrantFiled: March 11, 2013Date of Patent: March 1, 2016Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Kyle Hammerick
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Patent number: 9192698Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: June 30, 2015Date of Patent: November 24, 2015Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20150297806Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: June 30, 2015Publication date: October 22, 2015Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN
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Patent number: 9072681Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: October 15, 2013Date of Patent: July 7, 2015Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20140255464Abstract: Methods and apparatus for a biodegradable multi-layer device suitable for medical applications are provided, wherein the device is formed from multiple film-layers configured to have different characteristics from one another such as different release profiles for therapeutic agents, adhesive properties, stiffness properties, and solubility properties. The film-layers may include a solid fibrinogen component. A device having multiple film-layers may take a non-adherent form during delivery to a target location within or on tissue, and thereafter may be exposed to moisture to take an adherent form on the tissue. The device may include a number of additives, including materials to improve the mechanical properties of the device, or one or more therapeutic or contrast agents.Type: ApplicationFiled: March 11, 2013Publication date: September 11, 2014Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Kyle HAMMERICK
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Publication number: 20140046255Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: October 15, 2013Publication date: February 13, 2014Applicant: Bioinspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Patent number: 8563510Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: September 17, 2010Date of Patent: October 22, 2013Assignee: Bioinspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Patent number: 8529941Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: September 17, 2010Date of Patent: September 10, 2013Assignee: Bioinspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan