Abstract: The present invention is a condom coated with lactic acid bacteria contained composition, which has not only provided the contraceptive effect and the prevention of sexually transmitted diseases transmission but also helped to establish, maintain and reestablish a non-pathogenic, natural or genetically modified intra-vaginal bacterial flora action in vagina. The lactic acid bacteria can be genetically modified and natural lactic acid bacteria such as spreads from mammal intestinal and vaginal tract. A condom is coated with composition containing powder form or other type of lactic acid bacteria such as cream, foam, micro-bead or micro-encapsulated form, which contains as its ingredients at least one species of viable lactic acid bacteria, and optionally with a lubricant. The risk of pathogenic microbial and viral infection in vagina can be decreased or prevented and the vaginal environment can be maintained in a good condition without side effect by using a condom of the present invention.