Abstract: A device and method for the insertion of an analyte-selective microneedle array sensor into a dermal stratum of a user is disclosed herein. The device comprises a body portion, a recessed actuation portion, a carrier, a gating feature, and a disengagement feature. A user-directed application of a specified force to the actuation area causes the carrier to overcome the gating feature, thereby to effect the acceleration of the microneedle array sensor device towards the skin surface of a user with a specified impact force and velocity.
Type:
Application
Filed:
June 15, 2021
Publication date:
December 23, 2021
Applicant:
Biolinq, Inc.
Inventors:
David Michael Morelock, Scott James Sylliaasen, George Albert Mansfield, III, Pradnya Prakash Samant, Buddhadev Paul Chaudhuri, Andre Gamelin, Jared Rylan Tangney, Joshua Windmiller
Abstract: Devices and methods to mitigate the erroneous signal imparted by physical and/or chemical process incident upon analyte-selective electrochemical sensors that are non-analyte-related in origin are disclosed herein. A sensing system featuring at least one of an analyte-selective sensor and at least one of an analyte-invariant sensor.
Type:
Application
Filed:
July 2, 2021
Publication date:
December 9, 2021
Applicant:
Biolinq, Inc.
Inventors:
Joshua Ray Windmiller, Thomas Arnold Peyser, Alan Campbell, Pradnya Prakash Samant, Naresh Bhavaraju, Hooman Sedghamiz, David Morelock
Abstract: A skin-adorned physiological or biochemical sensing device is disclosed herein. The device preferably comprises a first substrate and a second substrate. The first substrate comprises an array of solid microneedles designed to penetrate a biological interface to access a physiological fluid or tissue. Each microneedle is capable of electrical interface with the physiological fluid or tissue. The second substrate comprises integrated circuitry designed to transduce at least one signal produced by an electrophysiological or electrochemical reaction. A sensing device is formed that is capable of interpreting the signal arising from the electrophysiological or electrochemical reaction to ascertain the level of some physiological or biochemical entity.
Abstract: Devices and methods for low-latency analyte quantification enabled by the implementation of a microneedle-based analyte-selective sensor operating in the dermis or viable epidermis are disclosed herein. The sensing element of the device is contained within the microneedle-based analyte-selective sensor and configured to penetrate the stratum corneum of the skin and become positioned in the viable epidermis or dermis of the wearer such that the sensing element is located a spatial distance no greater than 500 micrometers from the plexus of the dermis of the wearer.
Type:
Application
Filed:
October 17, 2020
Publication date:
June 24, 2021
Applicant:
Biolinq, Inc.
Inventors:
Joshua Windmiller, Jared Rylan Tangney, Thomas Arnold Peyser
Abstract: A device and method for the coupling of an analyte-selective sensor and an infusion system into a singular body-worn device is disclosed herein. Following the coupling, information and/or power is/are exchanged between the two modalities (analyte-selective sensor and an infusion system) by means of a wireless electromagnetic transmission or an electrical connector. The analyte-selective sensor is configured to penetrate the stratum corneum to access the viable epidermis or dermis and measure the presence of an analyte. The infusion system is configured to penetrate the stratum corneum and deliver a solution-phase therapeutic agent.
Type:
Application
Filed:
June 11, 2020
Publication date:
September 24, 2020
Applicant:
Biolinq, Inc.
Inventors:
Joshua Windmiller, Jared Rylan Tangney, Thomas Arnold Peyser
Abstract: A device and method for the manual delivery of a therapeutic intervention in response to a physiological state of a user is disclosed herein. The device comprises a sensor, an infusion system, and a singular body-worn component. The sensor is configured to penetrate the stratum corneum to access the viable epidermis or dermis and measure the presence of an analyte. The infusion system is configured to deliver a solution-phase therapeutic agent based on an action of the user or a control algorithm.
Type:
Application
Filed:
March 20, 2020
Publication date:
August 13, 2020
Applicant:
Biolinq, Inc.
Inventors:
Joshua Windmiller, Jared Rylan Tangney, Thomas Arnold Peyser
Abstract: Ketoacidosis is a medical emergency that requires swift intervention to avert life-threatening sequel. A body-worn sensor (50) configured to measure the levels of a ketone compound circulating in a physiological fluid of a wearer and capable of generating an alert to the wearer if the level of the circulating ketone compound exceeds a pre-defined level or rate of change is disclosed herein. The sensor (50) preferably includes at least one of an electrochemical sensor, an optical sensor, a galvanic sensor, a voltammetric sensor, an amperometric sensor, a potentiometric sensor, an impedimetric sensor, a resistive sensor, a capacitive sensor, an ultrasonic sensor, a radio-frequency sensor, or a microwave sensor.
Type:
Application
Filed:
December 3, 2019
Publication date:
April 2, 2020
Applicant:
Biolinq, Inc.
Inventors:
Joshua Windmiller, Jared Rylan Tangney, Thomas Arnold Peyser, John Sjolund
Abstract: A method and device to impart the ability to selectively quantify chemical/biochemical analytes occupying physiological fluids via an automated process that allow the precise and spatially-defined simultaneous deposition of a thin-film of polymer containing an immobilized biorecognition element dispersed therein. A tissue penetrating electrochemical sensor comprises at least one working electrode and at least one of a reference electrode and a counter electrode.
Abstract: A method and device to impart the ability to selectively quantify chemical/biochemical analytes occupying physiological fluids via an automated process that allow the precise and spatially-defined simultaneous deposition of a thin-film of polymer containing an immobilized biorecognition element dispersed therein. A tissue penetrating electrochemical sensor comprises at least one working electrode and at least one of a reference electrode and a counter electrode.
Abstract: A method (300) for constructing a solid-state reference electrode for use in an analyte-selective intracutaneously- or subcutaneously-implanted electrochemical cell is disclosed herein. The method (300) includes immersing a metallic electrode in a solution comprising a monomer precursor. The method (300) also includes applying a fixed or time-varying electrical potential or current to the metallic electrode, thereby serving to simultaneously electro-polymerize the monomer precursor and electro-deposit a conducting polymer, synthesized from the electro-polymerization of the monomer precursor, onto the said metallic electrode surface.
Type:
Application
Filed:
October 5, 2017
Publication date:
October 10, 2019
Applicant:
Biolinq, Inc.
Inventors:
Sirilak Sattayasamitsathit, Joshua Windmiller, Jared Tangney
Abstract: A method and device to impart the ability to selectively quantify chemical/biochemical analytes occupying physiological fluids via an automated process that allow the precise and spatially-defined simultaneous deposition of a thin-film of polymer containing an immobilized biorecognition element dispersed therein. A tissue penetrating electrochemical sensor comprises at least one working electrode and at least one of a reference electrode and a counter electrode.
Abstract: A miniaturized sub-nanoampere sensitivity low-noise potentiostat system is disclosed herein. The system includes an adjustable bias analog front end/potentiostat, a plurality of high input impedance and high gain difference amplifiers, means for signal filtering, a high-resolution analog-to-digital converter, and a sampling algorithm.