Abstract: Disclosed is a device for storing elements each including a first wireless communication unit, the device including: —a receiving support receiving the elements; —a second wireless communication unit generating waves and communicating with each first unit according to a communication protocol, a communication zone being a three-dimensional zone in which the second unit communicates with each first unit when each first unit is located in the zone and does not communicate with a first unit when the first unit is located outside the zone; —a waveguide able to guide the generated waves so that a dimension of the communication zone is strictly greater than a reference dimension, the reference dimension being equal to the dimension of the communication zone when the storage device is without waveguides.

Abstract: Cyclic dinucleotides are described, which in contrast to their natural congeners carry lipophilic nucleobases and have higher membrane permeability and increased biological activity.

Abstract: A device is provided for storing elements, each element including a first wireless communication unit. The device includes at least two drawer units each including: a drawer including a bottom defining at least one location for receiving an element; for each location, at least one second wireless communication unit including an antenna having a radiation-zone field, each antenna having a first state in which the antenna is activated and a second state in which the antenna is deactivated; and a data-processing unit able to control the activation and deactivation of the antenna of each second communication unit according to a control law.

Abstract: A device is provided for storing elements, each element including a first wireless communication unit. The device includes at least two drawer units each including: a drawer including a bottom defining at least one location for receiving an element; for each location, at least one second wireless communication unit including an antenna having a radiation-zone field, each antenna having a first state in which the antenna is activated and a second state in which the antenna is deactivated; and a data-processing unit able to control the activation and deactivation of the antenna of each second communication unit according to a control law.

Abstract: Disclosed is a method for managing at least one container containing a biological product, including the following steps: providing at least one container provided with a label, the label being a wireless communication chip capable of communicating according to a UHF mode and according to a HF mode, the chip being capable of transmitting or receiving a signal having a frequency of between 300 MHz and 3000 MHz in the UHF mode and having a frequency of between 3 MHz and 30 MHz in the HF mode, the label further including a memory; and reading at least one piece of information included in the memory, by a reader, the chip communicating with the reader according to the UHF mode or the HF mode.

Abstract: Disclosed is a method for carrying out an inventory of a plurality of biological product containers, each container and/or each package including containers being provided with an identification label comprising a wireless communication chip. The method includes the steps of: providing a device with a gantry defining a direction of travel; providing a receptacle able to be moved, the receptacle carrying the containers; moving the receptacle in order to cross the gantry in the direction of travel; and reading the wireless communication chip of each container and/or package during the movement of the receptacle.

Abstract: Provided is an anticancer compound including a cleavable linker specifically activated in a tumor microenvironment, and use thereof. The anticancer compound is represented by the following formula, wherein, R1 is a normal functional group or a protection group; R2 is Ala, Thr, Val or Ile; R3 is Ala, Val or Asn; R4 is a drug group linked via a hydroxyl group or an amino group; and the general formula of the drug is R4H. The anticancer compound is only activated at a local portion of a tumor, thus avoiding the defect of immune system damage of a traditional chemotherapeutic drug, and promoting tumor immunization by removing a tumor immunosuppression cell. The anticancer compound or pharmaceutical composition thereof is jointly used with immunotherapy, thus improving the effect of treating the tumor, and effectively inhibiting tumor metastasis and osseous metastasis.

Abstract: Disclosed is a method for carrying out an inventory of a plurality of biological product containers, each container and/or each package including containers being provided with an identification label including a wireless communication chip. The method includes the steps of: providing a device including a gantry defining a direction of travel; providing a receptacle able to be moved, the receptacle carrying the plurality of containers; moving the receptacle in order to cross the gantry in the direction of travel; and reading the wireless communication chip of each container and/or package during the movement of the receptacle.

Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.

Abstract: The present invention is related to compositions and methods to treat, ameliorate and/or prevent morbidity and/or mortality from microbial infections. In particular, bacterial infections that are associated with the production and release of bacterial toxins. For example, many Clostridia bacteria, such as Clostridium difficile, release toxins resulting in tissue and organ damage and death, even after antibiotic therapy that either reduces or eliminates the bacteria. In particular, various peptides, polypeptides, and proteins are disclosed herein that either inactivate Clostridium difficile toxin and/or reduce Clostridium difficile toxin production.

Abstract: The present invention relates to novel boranophosphate analogues of cyclic nucleotides. The invention further relates to the use of such compounds as reagents for signal transduction research or as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and/or as hydrolysis- and oxidation-resistant ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces and/or as additive for organ transplantation storage solutions.

Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.