Patents Assigned to BIOLOG Life Science Institute
  • Cyclic dinucleotides containing benzimidazole, method for the production of same, and use of same to activate stimulator of interferon genes (sting)-dependent signaling pathways
    Patent number: 11001605
    Abstract: Cyclic dinucleotides are described, which in contrast to their natural congeners carry lipophilic nucleobases and have higher membrane permeability and increased biological activity.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: May 11, 2021
    Assignee: BIOLOG LIFE SCIENCE INSTITUTE GMBH & CO. KG
    Inventors: Hans-Gottfried Genieser, Frank Schwede, Andreas Rentsch
  • NAD analogs and methods of using said NAD analogs in determining ribosylation of proteins with PARP mutants
    Patent number: 9926340
    Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: March 27, 2018
    Assignees: The Board of Regents of the University of Texas System, Biolog Life Science Institute Forshungslabor und Biochemica-Vertrieb GmbH, Cornell University
    Inventors: W. Lee Kraus, Bryan A. Gibson, Frank Schwede, Hening Lin
  • Boranophosphate analogues of cyclic nucleotides
    Patent number: 9487553
    Abstract: The present invention relates to novel boranophosphate analogues of cyclic nucleotides. The invention further relates to the use of such compounds as reagents for signal transduction research or as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and/or as hydrolysis- and oxidation-resistant ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces and/or as additive for organ transplantation storage solutions.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: November 8, 2016
    Assignee: BIOLOG LIFE SCIENCE INSTITUTE FORSCHUNGSLABOR UND BIOCHEMICA-VERTRIEB GMBH
    Inventor: Hans-Gottfried Genieser
  • NAD ANALOGS AND METHODS OF USING SAID NAD ANALOGS IN DETERMINING RIBOSYLATION OF PROTEINS WITH PARP MUTANTS
    Publication number: 20160299141
    Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.
    Type: Application
    Filed: April 1, 2016
    Publication date: October 13, 2016
    Applicants: Biolog Life Science Institute Forschungslabor und Biochemica-Vertrieb GmbH, Cornell University
    Inventors: W. Lee KRAUS, Bryan A. GIBSON, Frank SCHWEDE, Hening LIN
  • NEW BORANOPHOSPHATE ANALOGUES OF CYCLIC NUCLEOTIDES
    Publication number: 20140088033
    Abstract: The present invention relates to novel boranophosphate analogues of cyclic nucleotides. The invention further relates to the use of such compounds as reagents for signal transduction research or as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and/or as hydrolysis- and oxidation-resistant ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces and/or as additive for organ transplantation storage solutions.
    Type: Application
    Filed: March 27, 2012
    Publication date: March 27, 2014
    Applicant: BIOLOG LIFE SCIENCE INSTITUTE FORSCHUNGSLABOR UND BIOCHEMICA-VERTRIEB GMBH
    Inventor: Hans-Gottfried Genieser
  • Derivatives of cyclic guanosine-3',5'-monophosphorothioate
    Patent number: 5625056
    Abstract: New derivatives of S.sub.P - and R.sub.P -configures cyclic guanosine-3',5'-phosphorothioates and their physiologically and pharmaceutically acceptable salts according to the general formula ##STR1## are cell membrane permeable inhibitors (R.sub.P -isomers) and stimulators (S.sub.P -isomers) of cyclic GMP-dependent protein kinase which are resistant against phosphodiesterase degradation and suitable as ligands for affinity chromatography of cyclic nucleotide-dependent binding proteins.
    Type: Grant
    Filed: August 7, 1995
    Date of Patent: April 29, 1997
    Assignee: BIOLOG Life Science Institute
    Inventors: Hans-Gottfried Genieser, Ulrich Walter, Elke Butt