Patents Assigned to BIOLOG LIFE SCIENCE INSTITUTE FORSCHUNGSLABOR UND BIOCHEMICA-VERTRIEB GMBH
  • Boranophosphate analogues of cyclic nucleotides
    Patent number: 9487553
    Abstract: The present invention relates to novel boranophosphate analogues of cyclic nucleotides. The invention further relates to the use of such compounds as reagents for signal transduction research or as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and/or as hydrolysis- and oxidation-resistant ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces and/or as additive for organ transplantation storage solutions.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: November 8, 2016
    Assignee: BIOLOG LIFE SCIENCE INSTITUTE FORSCHUNGSLABOR UND BIOCHEMICA-VERTRIEB GMBH
    Inventor: Hans-Gottfried Genieser
  • NAD ANALOGS AND METHODS OF USING SAID NAD ANALOGS IN DETERMINING RIBOSYLATION OF PROTEINS WITH PARP MUTANTS
    Publication number: 20160299141
    Abstract: The present disclosure provides NAD analogs of the formula: wherein R1, n, and X1 are defined herein, useful for the identification of PARP target proteins and the amino acid sequence wherein the ribose group is attached to the target protein. Also, provided herein are methods of identifying target protein and amino acid sequences. Additionally, the present disclosure provides methods of identifying DNA sequences associated with specific chromatin proteins.
    Type: Application
    Filed: April 1, 2016
    Publication date: October 13, 2016
    Applicants: Biolog Life Science Institute Forschungslabor und Biochemica-Vertrieb GmbH, Cornell University
    Inventors: W. Lee KRAUS, Bryan A. GIBSON, Frank SCHWEDE, Hening LIN
  • NEW BORANOPHOSPHATE ANALOGUES OF CYCLIC NUCLEOTIDES
    Publication number: 20140088033
    Abstract: The present invention relates to novel boranophosphate analogues of cyclic nucleotides. The invention further relates to the use of such compounds as reagents for signal transduction research or as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and/or as hydrolysis- and oxidation-resistant ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces and/or as additive for organ transplantation storage solutions.
    Type: Application
    Filed: March 27, 2012
    Publication date: March 27, 2014
    Applicant: BIOLOG LIFE SCIENCE INSTITUTE FORSCHUNGSLABOR UND BIOCHEMICA-VERTRIEB GMBH
    Inventor: Hans-Gottfried Genieser