Patents Assigned to BIOLOGICAL E LIMITED
  • Method for separation of protein and other impurities from microbial capsular polysaccharides
    Patent number: 10836839
    Abstract: The invention relates to a method for the removal of protein and other impurities from microbial capsular polysaccharides. More particularly, the present invention relates to isolation of microbial capsular polysaccharides in pure form after removal of protein and other impurities.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: November 17, 2020
    Assignee: BIOLOGICAL E LIMITED
    Inventors: Ramesh Venkat Matur, Vivek Babu Kandimalla, Narender Dev Mantena, Mahima Datla, Muthyala Venkateswara Reddy, Kantam Charan
  • Method for preparation of aluminium phosphate gel for application in vaccine formulations
    Patent number: 10744200
    Abstract: The present invention relates to an improved process for production of Aluminium phosphate (AlPhos) gel wherein the solutions of aluminium salt and alkaline phosphate salt are added to water by maintaining the pH under stirring to obtain the precipitate, followed by sterilization of the said precipitate and finally obtaining the Aluminum phosphate gel.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: August 18, 2020
    Assignee: BIOLOGICAL E LIMITED
    Inventors: Ravi Ganapathy, Nagireddy Gade, Manish Manohar, Vikram Madhusadan Paradkar, Mahima Datla
  • Codon optimized polynucleotide for high level expression of CRM197
    Patent number: 10280409
    Abstract: The present invention relates to high level expression of bacterial toxoid or toxin protein of pharmacological interest by means of an optimized novel polynucleotide sequence and host transformed with the said polynucleotide. Specifically, the invention provides a method for high production of polypeptide CRM197 wherein, the polynucleotide of the invention is used to transform a suitable host resulting in over-expression of corresponding proteins and a method for isolating the expressed polypeptide. More particularly, the present invention relates to high level expression of CRM197 in Escherichia coli and a method for the isolation and purification thereof.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: May 7, 2019
    Assignee: BIOLOGICAL E LIMITED
    Inventors: Akshay Goel, Ravi Pratap Narayan Mishra, Narender Dev Mantena, Mahima Datla
  • METHOD FOR SEPARATION OF PROTEIN AND OTHER IMPURITIES FROM MICROBIAL CAPSULAR POLYSACCHARIDES
    Publication number: 20180155453
    Abstract: The invention relates to a method for the removal of protein and other impurities from microbial capsular polysaccharides. More particularly, the present invention relates to isolation of microbial capsular polysaccharides in pure form after removal of protein and other impurities.
    Type: Application
    Filed: April 25, 2016
    Publication date: June 7, 2018
    Applicant: BIOLOGICAL E LIMITED
    Inventors: Ramesh Venkat Matur, Vivek Babu Kandimalla, Narender Dev Mantena, Mahima Datla, Muthyala Venkateswara Reddy, Kantam Charan