Patents Assigned to Biology Centre AS CR, V.V.I.
  • Manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E
    Patent number: 9447062
    Abstract: A manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E. Colabomycin E is a new member of the manumycin-type metabolites produced by the strain Streptomyces aureus SOK1/5-04 deposited in The Czech collection of microorganisms under number CCM8556. The structure of 5 is similar to that of the already known metabolite colabomycin A (3) isolated from Streptomyces griseoflavus. However, the upper polyene chain of 5 is two carbons longer. Therefore, it was named Colabomycin E. Biological activity assays indicated that colabomycin E significantly inhibited IL-1? release from THP-1 cells and might thus potentially act as an anti-inflammatory agent.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: September 20, 2016
    Assignees: BIOLOGY CENTRE AS CR, V.V.I., INSTITUTE OF MICROBIOLOGYH AS CR, V.V.I., INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE
    Inventors: Miroslav Petricek, Katerina Petrickova, Stanislav Pospisil, Marek Kuzma, Alica Chronakova, Vaclav Kristufek, Ilja Striz
  • Manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E
    Publication number: 20160168106
    Abstract: A manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E. Colabomycin E is a new member of the manumycin-type metabolites produced by the strain Streptomyces aureus SOK1/5-04 deposited in The Czech collection of microorganisms under number CCM8556. The structure of 5 is similar to that of the already known metabolite colabomycin A (3) isolated from Streptomyces griseoflavus. However, the upper polyene chain of 5 is two carbons longer. Therefore, it was named Colabomycin E. Biological activity assays indicated that colabomycin E significantly inhibited IL-1? release from THP-1 cells and might thus potentially act as an anti-inflammatory agent.
    Type: Application
    Filed: December 15, 2014
    Publication date: June 16, 2016
    Applicants: BIOLOGY CENTRE AS CR, v. v. i.,, INSTITUTE OF MICROBIOLOGY AS CR, v. v. i., INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE
    Inventors: Miroslav Petricek, Katerina Petrickova, Stanislav Pospisil, Marek Kuzma, Alica Chronakova, Vaclav Kristufek, Ilja Striz
  • Strain of entomopathogenic fungus CCM 8367 (CCEFO.011.PFR) and the method for controlling insect and mite pests
    Patent number: 8574566
    Abstract: Strain of entomopathogenic fungus Isaria fumosorosea CCM 8367 (CCEFO.011.PFR) deposited in collection CCM (Czech Collection of Microorganisms) in Brno, applicable for biological control of substrates infested by insect and mite pests. Infested woods, plants, etc. are treated with blastospores or conidiospores of this strain.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: November 5, 2013
    Assignees: Biology Centre AS CR, V.V.I.
    Inventors: Eva Prenerova, Rostislav Zemek, Lubomir Volter, Frantisek Weyda
  • Ferritin 2 for the host immunization against ticks
    Patent number: 8168763
    Abstract: Ferritin 2 is a tick secreted protein, which serves in the tick plasma as a non-heme iron transporter from the gut to the peripheral tissues. It can be exploited as an antigen for raising up host antibodies, which can reversely block this antigen in the tick and the attached tick will not have functional mechanism of the non-heme iron transport from the gut to the peripheral tissues. This mechanism is essential for the further tick development and its blocking eventually prevents transmission of tick-borne pathogens.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: May 1, 2012
    Assignee: Biology Centre AS CR, V.V.I.
    Inventors: Petr Kopacek, Ondrej Hajdusek