Patents Assigned to BioMark Technologies Inc.
  • Method for assaying the activity of spermidine/spermine N-acetyltransferase
    Patent number: 11441168
    Abstract: A method for assaying activity of the enzyme spermidine/spermine N1-acetyltransferase (SSAT) uses SSAT substrates by detecting their acetylated forms. SSAT substrates may include rimantadine and tocainide wherein their metabolism occurs in part by the action of the inducible enzyme SSAT to produce the acetylated metabolites N-acetylrimantadine and N-acetyltocainide respectively. SSAT activity may be correlated to pathologic conditions.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: September 13, 2022
    Assignee: BioMark Technologies Inc.
    Inventors: Brian Cheng, Rashid Bux, Daniel Sitar
  • Method For Assaying The Activity Of Spermidine/Spermine N1-Acetyltransferase
    Publication number: 20220033875
    Abstract: A method for assaying activity of the enzyme spermidine/spermine N1-acetyltransferase (SSAT) uses SSAT substrates by detecting their acetylated forms. SSAT substrates may include rimantadine and tocainide wherein their metabolism occurs in part by the action of the inducible enzyme SSAT to produce the acetylated metabolites N-acetylrimantadine and N-acetyltocainide respectively. SSAT activity may be correlated to pathologic conditions.
    Type: Application
    Filed: August 19, 2021
    Publication date: February 3, 2022
    Applicant: BioMark Technologies Inc.
    Inventors: Brian CHENG, Rashid BUX, Daniel SITAR
  • Detection and quantification of acetylamantadine in urine samples
    Patent number: 10175226
    Abstract: A method for quantifying acetylamantadine in a urine sample comprises eluting acetylamantadine from the urine sample using solid phase extraction and quantifying the acetylamantadine eluted from the urine sample using Raman spectroscopy.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: January 8, 2019
    Assignee: BioMark Technologies, Inc.
    Inventors: Reuven Gordon, Brian Cheng, Rashid Bux, Bram Ramjiawan, Aftab Ahmed, Fraser Alan Hof
  • Detection And Quantification Of Acetylamantadine In Urine Samples
    Publication number: 20170328881
    Abstract: A method for quantifying acetylamantadine in a urine sample comprises eluting acetylamantadine from the urine sample using solid phase extraction and quantifying the acetylamantadine eluted from the urine sample using Raman spectroscopy.
    Type: Application
    Filed: July 10, 2017
    Publication date: November 16, 2017
    Applicant: BioMark Technologies, Inc.
    Inventors: Reuven Gordon, Brian Cheng, Rashid Bux, Bram Ramjiawan, Aftab Ahmed, Fraser Alan Hof
  • Method Of Detecting Cancer Based On Spermine/Spermidine N'-Acetyltransferase Gene Expression
    Publication number: 20170209272
    Abstract: Elevated levels of spermidine/spermine N1-acetyltransferase (SSAT) gene expression expression were observed in breast, prostate and lung cancer cell lines. Elevated levels of SSAT gene expression were verified in tissues from patients with breast, prostate and lung cancer. Elevated SSAT gene expression is elevated in different human cancers and elevated SSAT gene expression may accordingly serve as a companion diagnostic biomarker for detection and monitoring of cancer progression.
    Type: Application
    Filed: June 9, 2015
    Publication date: July 27, 2017
    Applicant: BioMark Technologies Inc.
    Inventors: Rashid Bux, Brian Cheng, Paramjit S. Tappia, Bram Ramjiawan
  • An Immunological Assay To Detect And Quantify Acetylamantadine
    Publication number: 20160223527
    Abstract: An immunological assay detects and quantifies acetylamantadine in the urine or other bodily fluids of a person who has taken a small dose of amantadine. The quantification of acetylamantadine can be used to quantify SSAT activity and elevated SSAT activity is an indication of diseases including, but not limited, to inflammations and cancers.
    Type: Application
    Filed: August 29, 2014
    Publication date: August 4, 2016
    Applicant: BioMark Technologies Inc.
    Inventor: Brian Cheng
  • Spermidine/Spermine N1 - Acetyltransferase Antibodies As Anti-Cancer Drug Compounds
    Publication number: 20160017054
    Abstract: An anti-cancer drug compound comprises a spermidine/spermine N1-acetyltransferase antibody. The spermidine/spermine N1-acetyltransferase antibody may be a monoclonal antibody or a polyclonal antibody. A method of treating cancer comprises the use of a spermidine/spermine N1-acetyltransferase antibody. The spermidine/spermine N1-acetyltransferase antibody may be a monoclonal antibody or a polyclonal antibody.
    Type: Application
    Filed: January 30, 2014
    Publication date: January 21, 2016
    Applicant: Biomark Technologies Inc.
    Inventors: Brian Cheng, Rashid Bux, Derek Cheng
  • Method For Assaying The Activity Of Spermidine/Spermine N1-Acetyltransferase
    Publication number: 20140315217
    Abstract: A method for assaying activity of the enzyme spermidine/spermine N1-acetyltransferase (SSAT) uses SSAT substrates by detecting their acetylated forms. SSAT substrates may include rimantadine and tocainide wherein their metabolism occurs in part by the action of the inducible enzyme SSAT to produce the acetylated metabolites N-acetylrimantadine and N-acetyltocainide respectively. SSAT activity may be correlated to pathologic conditions.
    Type: Application
    Filed: November 16, 2012
    Publication date: October 23, 2014
    Applicant: BioMark Technologies Inc.
    Inventors: Brian Cheng, Rashid Bux, Daniel Sitar
  • Monoclonal Antibody For Acetylamantadine
    Publication number: 20140287446
    Abstract: A method of producing an antibody comprises immunizing a mammal with an amine-derivative of acetylamantadine, immunizing the mammal with acetylamantadine, and producing the antibody from the mammal. The antibody recognizes acetylamantadine but does not recognize amantadine.
    Type: Application
    Filed: May 11, 2012
    Publication date: September 25, 2014
    Applicant: BioMark Technologies Inc.
    Inventors: Brian Cheng, Rashid Bux, Gregorio Aversa, Bram Ramjiawan, Daniel Sitar