Abstract: Novel physiologically active substance designated as epimorphin which is capable of being expressed by a gene hybridizing with a gene probe composed of the base sequence complementary to part of the base sequence of Sequence ID No. 1 in Sequence Listing, and which is produced by mesenchymal cells derived from human or mouse, and which shows morphogenetic activity of epithelial tissue, and isoforms of the epimorphin, base sequences encoding them, modified epimorphin, in which hydrophobic region at the carboxy terminal of the epimorphin polypeptide has been deleted or replaced by non-hydrophobic polypeptide, and polyclonal antibody or monoclonal antibody produced by the use of a full length or a part of the epimorphin as an antigen are provided. The substances of the present invention can be used for elucidation of the mechanism of diseases caused by abnormal epithelium formation, diagnosis of such diseases, or development of therapeutic methods therefor.

Abstract: An aromatic polysulfone polymer, and a molded article thereof, having an aromatic nucleus to which is introduced a group having the following general formula (I):A--CH(R.sup.1)--CO--N(R.sup.2)--CH.sub.2 -- (I)wherein, A is a halogen atom, hydroxyl group, amino compound residual group, acyloxyl group, alkoxyl group, phenoxyl group, or sulfide group, R.sup.1 and R.sup.2 are a hydrogen atom or lower alkyl group, and R.sup.1 and R.sup.2 may be the same or different to a main chain of aromatic polysulfone as a side chain.