Abstract: Compositions for enhancing memory of a subject comprising a combination of a positive modulator of an AMPA receptor and a positive modulator of an NMDA receptor are provided, wherein each modulator of the combination is present at a subtherapeutic dose for effecting memory enhancement. Methods for using such compositions in the treatment of cognitive impairment associated with aging, age-related diseases, and CNS disorders, for example, are provided. New fusion molecules are also provided that combine the positive modulator functionalities into one molecule.

Abstract: A cap removal device is provided for a cellular sample treatment apparatus. The device avoids the necessity to manually remove a cap and allows an automated sequence of steps to be carried out. The device is utilized in an apparatus for treating samples of cellular materials wherein the samples are contained in a stack of sample holders and fit in a stack holding tube, open at the top with a removable cap. A transfer tube having a bottom opening to fit on the top of the stack holding tube is provided and has a drive system to move the stack from the stack holding tube to the transfer tube. The improvement includes a fork attached to the drive system for the stack removal, and a button or grooved member on the cap for engagement by the fork so that when the drive system moves upwards it lifts the cap with it.

Abstract: A magnetic lifting device for lifting a stack of specimen holders out of one tube and lowering them into another tube is disclosed. The device avoids the necessity of manual handling of the stack. In the device there are a number of stack holding tubes, each one open at the top, positioned in a circle about a vertical axis of a rotatable carousel. An indexing system rotates the carousel to selectively place one of the stack holding tubes in a treatment position. The improvement comprises a magnetizable member attached to the top of the stack of sample holders, a transfer tube having a bottom opening positioned to mate on top of the stack holding tube to hold the magnetizable member in a magnetic field, a device to raise and lower the magnetic coil about the transfer tube to raise and lower the magnetic coil about the transfer tube to raise the stack into the transfer tube allowing the carousel to be rotated, and lower the stack into another stack holding tube.