Patents Assigned to Biomatrica, Inc.
  • Patent number: 12121022
    Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.
    Type: Grant
    Filed: May 26, 2023
    Date of Patent: October 22, 2024
    Assignee: Biomatrica, Inc.
    Inventors: Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
  • Patent number: 12089588
    Abstract: The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.
    Type: Grant
    Filed: August 12, 2021
    Date of Patent: September 17, 2024
    Assignee: Biomatrica, Inc.
    Inventors: Joel Desharnais, Victoria Arendt, Margrith Mattmann
  • Patent number: 11672247
    Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: June 13, 2023
    Assignee: Biomatrica, Inc.
    Inventors: Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
  • Publication number: 20210368779
    Abstract: The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.
    Type: Application
    Filed: August 12, 2021
    Publication date: December 2, 2021
    Applicant: Biomatrica, Inc.
    Inventors: Joel Desharnais, Victoria Arendt, Margrith Mattmann
  • Patent number: 11116205
    Abstract: The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: September 14, 2021
    Assignee: BIOMATRICA, INC.
    Inventors: Joel Desharnais, Victoria Arendt, Margrith Mattmann
  • Patent number: 11078521
    Abstract: The present invention and embodiments thereof relates to compositions and methods for storage, stabilization and preservation of biological samples and/or nucleic acids on a solid matrix. Methods for extracting, collecting, and recovering the biological samples and/or nucleic acids from the solid matrix are also described.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: August 3, 2021
    Assignee: BIOMATRICA, INC.
    Inventors: Joel Desharnais, Daniela Roth, Vasco Liberal
  • Patent number: 10772319
    Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: September 15, 2020
    Assignee: Biomatrica, Inc.
    Inventors: Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
  • Patent number: 10568317
    Abstract: The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: February 25, 2020
    Assignee: Biomatrica, Inc.
    Inventors: Joel Desharnais, Victoria Arendt, Margrith Mattmann
  • Patent number: 10064404
    Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: September 4, 2018
    Assignee: BIOMATRICA, INC.
    Inventors: Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
  • Patent number: 9999217
    Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: June 19, 2018
    Assignee: Biomatrica, Inc.
    Inventors: Scott E. Whitney, Steven Wilkinson, Rolf Muller
  • Patent number: 9845489
    Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: December 19, 2017
    Assignee: BIOMATRICA, INC.
    Inventors: Scott E. Whitney, Senait Ghirmai, Rolf Muller
  • Patent number: 9725703
    Abstract: Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: August 8, 2017
    Assignee: Biomatrica, Inc.
    Inventors: Scott E. Whitney, Stephanie De Los Rios, Senait Ghirmai, Rolf Muller, Vasco Liberal, Steven P. Wilkinson
  • Publication number: 20170198335
    Abstract: Provided herein are formulations for the stabilization of one or more polypeptide or nucleic acid molecule in a native, non-denatured state at ambient temperatures. Also provided are compositions, articles of manufacture, kits and methods for substantially stable storage of one or more polypeptide or nucleic acid molecule in a native, non-denatured, and/or functionally active conformation substantially free on intracellular polypeptides and nucleic acids at ambient temperatures are provided. Also provided are formulations for the stabilization of one or more exosome at ambient temperatures, and compositions, articles of manufacture, kits and methods of use.
    Type: Application
    Filed: June 9, 2015
    Publication date: July 13, 2017
    Applicant: Biomatrica, Inc.
    Inventors: Rolf MULLER, Scott WHITNEY, Paul DIAZ
  • Patent number: 9376709
    Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration in a form that permits recovery of intact DNA or RNA components following the storage period.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: June 28, 2016
    Assignee: Biomatrica, Inc.
    Inventors: Scott E. Whitney, Steven Wilkinson, Rolf Muller
  • Patent number: 9078426
    Abstract: Compositions and methods are disclosed for automated storing, tracking, retrieving and analyzing biological samples, including dry storage at ambient temperatures of nucleic acids, proteins (including enzymes), and cells using a dry storage matrix that permits recovery of biologically active materials. RFID-tagged biological sample storage devices featuring dissolvable or dissociable matrices are described for use as supports of biological samples, which matrices can be dried and subsequently rehydrated for sample recovery. Also disclosed are computer-implemented systems and methods for managing sample data.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: July 14, 2015
    Assignee: Biomatrica, Inc.
    Inventors: Judy Muller-Cohn, Rolf Muller
  • Patent number: 8900856
    Abstract: Compositions and methods are disclosed for automated storing, tracking, retrieving and analyzing biological samples, including dry storage at ambient temperatures of nucleic acids, proteins (including enzymes), and cells using a dry storage matrix that permits recovery of biologically active materials. RFID-tagged biological sample storage devices featuring dissolvable or dissociable matrices are described for use as supports of biological samples, which matrices can be dried and subsequently rehydrated for sample recovery. Also disclosed are computer-implemented systems and methods for managing sample data.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: December 2, 2014
    Assignee: Biomatrica, Inc.
    Inventors: Judy Muller-Cohn, Rolf Muller, Corinna Herrnstadt
  • Publication number: 20140065627
    Abstract: Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
    Type: Application
    Filed: August 13, 2013
    Publication date: March 6, 2014
    Applicant: Biomatrica, Inc.
    Inventors: Scott E. Whitney, Sohela de Rozieres, Rolf Muller
  • Patent number: 8519125
    Abstract: Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: August 27, 2013
    Assignee: Biomatrica, Inc.
    Inventors: Scott E. Whitney, Sohela De Rozieres, Rolf Muller
  • Publication number: 20130209997
    Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.
    Type: Application
    Filed: July 26, 2011
    Publication date: August 15, 2013
    Applicant: BIOMATRICA, INC.
    Inventors: Scott E. Whitney, Senait Ghirmai, Rolf Muller
  • Publication number: 20110081363
    Abstract: Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
    Type: Application
    Filed: May 11, 2010
    Publication date: April 7, 2011
    Applicant: BIOMATRICA, INC.
    Inventors: Scott E. Whitney, Sohela De Rozieres, Rolf Muller