Patents Assigned to Biomatrica, Inc.
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Patent number: 12121022Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.Type: GrantFiled: May 26, 2023Date of Patent: October 22, 2024Assignee: Biomatrica, Inc.Inventors: Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
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Patent number: 12089588Abstract: The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.Type: GrantFiled: August 12, 2021Date of Patent: September 17, 2024Assignee: Biomatrica, Inc.Inventors: Joel Desharnais, Victoria Arendt, Margrith Mattmann
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Patent number: 11672247Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.Type: GrantFiled: July 17, 2020Date of Patent: June 13, 2023Assignee: Biomatrica, Inc.Inventors: Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
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Publication number: 20210368779Abstract: The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.Type: ApplicationFiled: August 12, 2021Publication date: December 2, 2021Applicant: Biomatrica, Inc.Inventors: Joel Desharnais, Victoria Arendt, Margrith Mattmann
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Patent number: 11116205Abstract: The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.Type: GrantFiled: February 24, 2020Date of Patent: September 14, 2021Assignee: BIOMATRICA, INC.Inventors: Joel Desharnais, Victoria Arendt, Margrith Mattmann
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Patent number: 11078521Abstract: The present invention and embodiments thereof relates to compositions and methods for storage, stabilization and preservation of biological samples and/or nucleic acids on a solid matrix. Methods for extracting, collecting, and recovering the biological samples and/or nucleic acids from the solid matrix are also described.Type: GrantFiled: October 24, 2017Date of Patent: August 3, 2021Assignee: BIOMATRICA, INC.Inventors: Joel Desharnais, Daniela Roth, Vasco Liberal
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Patent number: 10772319Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.Type: GrantFiled: July 30, 2018Date of Patent: September 15, 2020Assignee: Biomatrica, Inc.Inventors: Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
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Patent number: 10568317Abstract: The present invention relates to reduction of erythrocyte sedimentation rate in a blood sample. In particular, formulations, compositions, articles of manufacture, kits and methods for reduced erythrocyte sedimentation rate in a blood sample are provided.Type: GrantFiled: December 6, 2016Date of Patent: February 25, 2020Assignee: Biomatrica, Inc.Inventors: Joel Desharnais, Victoria Arendt, Margrith Mattmann
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Patent number: 10064404Abstract: Provided herein are formulations and methods for the stabilization of one or more thrombocytes at ambient temperatures. Also provided are formulations and methods for the stabilization of one or more thrombocytes in an inactivated state in a blood sample at ambient temperatures. Further provided are articles of manufacture and kits and methods for substantially stable storage of one or more thrombocyte at ambient temperatures.Type: GrantFiled: June 9, 2015Date of Patent: September 4, 2018Assignee: BIOMATRICA, INC.Inventors: Rolf Muller, Joel Desharnais, Steven P. Wilkinson, Victoria Arendt, Paul Diaz
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Patent number: 9999217Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.Type: GrantFiled: May 25, 2016Date of Patent: June 19, 2018Assignee: Biomatrica, Inc.Inventors: Scott E. Whitney, Steven Wilkinson, Rolf Muller
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Patent number: 9845489Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.Type: GrantFiled: July 26, 2011Date of Patent: December 19, 2017Assignee: BIOMATRICA, INC.Inventors: Scott E. Whitney, Senait Ghirmai, Rolf Muller
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Patent number: 9725703Abstract: Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.Type: GrantFiled: December 20, 2013Date of Patent: August 8, 2017Assignee: Biomatrica, Inc.Inventors: Scott E. Whitney, Stephanie De Los Rios, Senait Ghirmai, Rolf Muller, Vasco Liberal, Steven P. Wilkinson
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Publication number: 20170198335Abstract: Provided herein are formulations for the stabilization of one or more polypeptide or nucleic acid molecule in a native, non-denatured state at ambient temperatures. Also provided are compositions, articles of manufacture, kits and methods for substantially stable storage of one or more polypeptide or nucleic acid molecule in a native, non-denatured, and/or functionally active conformation substantially free on intracellular polypeptides and nucleic acids at ambient temperatures are provided. Also provided are formulations for the stabilization of one or more exosome at ambient temperatures, and compositions, articles of manufacture, kits and methods of use.Type: ApplicationFiled: June 9, 2015Publication date: July 13, 2017Applicant: Biomatrica, Inc.Inventors: Rolf MULLER, Scott WHITNEY, Paul DIAZ
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Patent number: 9376709Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration in a form that permits recovery of intact DNA or RNA components following the storage period.Type: GrantFiled: July 26, 2011Date of Patent: June 28, 2016Assignee: Biomatrica, Inc.Inventors: Scott E. Whitney, Steven Wilkinson, Rolf Muller
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Patent number: 9078426Abstract: Compositions and methods are disclosed for automated storing, tracking, retrieving and analyzing biological samples, including dry storage at ambient temperatures of nucleic acids, proteins (including enzymes), and cells using a dry storage matrix that permits recovery of biologically active materials. RFID-tagged biological sample storage devices featuring dissolvable or dissociable matrices are described for use as supports of biological samples, which matrices can be dried and subsequently rehydrated for sample recovery. Also disclosed are computer-implemented systems and methods for managing sample data.Type: GrantFiled: July 30, 2008Date of Patent: July 14, 2015Assignee: Biomatrica, Inc.Inventors: Judy Muller-Cohn, Rolf Muller
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Patent number: 8900856Abstract: Compositions and methods are disclosed for automated storing, tracking, retrieving and analyzing biological samples, including dry storage at ambient temperatures of nucleic acids, proteins (including enzymes), and cells using a dry storage matrix that permits recovery of biologically active materials. RFID-tagged biological sample storage devices featuring dissolvable or dissociable matrices are described for use as supports of biological samples, which matrices can be dried and subsequently rehydrated for sample recovery. Also disclosed are computer-implemented systems and methods for managing sample data.Type: GrantFiled: April 8, 2005Date of Patent: December 2, 2014Assignee: Biomatrica, Inc.Inventors: Judy Muller-Cohn, Rolf Muller, Corinna Herrnstadt
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Publication number: 20140065627Abstract: Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.Type: ApplicationFiled: August 13, 2013Publication date: March 6, 2014Applicant: Biomatrica, Inc.Inventors: Scott E. Whitney, Sohela de Rozieres, Rolf Muller
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Patent number: 8519125Abstract: Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.Type: GrantFiled: May 11, 2010Date of Patent: August 27, 2013Assignee: Biomatrica, Inc.Inventors: Scott E. Whitney, Sohela De Rozieres, Rolf Muller
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Publication number: 20130209997Abstract: Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.Type: ApplicationFiled: July 26, 2011Publication date: August 15, 2013Applicant: BIOMATRICA, INC.Inventors: Scott E. Whitney, Senait Ghirmai, Rolf Muller
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Publication number: 20110081363Abstract: Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.Type: ApplicationFiled: May 11, 2010Publication date: April 7, 2011Applicant: BIOMATRICA, INC.Inventors: Scott E. Whitney, Sohela De Rozieres, Rolf Muller