Patents Assigned to Biomed
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Patent number: 11986195Abstract: A device, a thrombectomy apparatus and a method for extraction of thrombus from a blood vessel are disclosed. The device comprises a segment changing its shape from a retracted position in a compressed state to an extended and expanded position. The segment is formed by a mesh of at least two sets of helicoidal filaments turning respectively in opposite directions and being intertwined. The mesh comprises two distinct tubular sections. The mesh of the first section has helicoidal filaments with a braiding angle providing radial forces higher than in the second section, thus the first section becomes appositioned against the inner wall of the blood vessel. The second section comprises two sub-sections. The first sub-section has a conical shape and comprises a braiding angle changing at its proximal and distal ends to provide radial strength to maintain the conical shape and to stop a proximal blood flow during the removal of the thrombus.Type: GrantFiled: October 16, 2019Date of Patent: May 21, 2024Assignee: Anaconda Biomed, S.L.Inventors: Ignacio Cortiñas Villazón, Ane Lizarazu González, Ofir Arad Hadar, Iñaki Galve Murillo
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Publication number: 20240156389Abstract: A method for health monitoring of a subject. The method includes measuring each of a plurality of physiological parameters once per a respective time period of a plurality of time periods. Measuring each of the plurality of physiological parameters includes measuring a heart rate of the plurality of physiological parameters by installing a sensor package on a region at a right side of a chest of the subject Installing the sensor package on the region includes placing a pair of electrocardiography (ECG) electrodes and an accelerometer in the sensor package on the region which includes the anterior edge of the right serratus anterior muscle of the subject.Type: ApplicationFiled: March 18, 2021Publication date: May 16, 2024Applicant: Ortho Biomed Inc.Inventors: Mansour Abolghasemian, Jamal Esmaelpoor, Babak Vaseghi, Masoud Sadeghisheikhtabaghi, Seyed Babak Zianamin
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Patent number: 11974726Abstract: A tissue detection system includes a probe having a body and an emission optical fiber extending from an input end through the probe body to an output end at a distal end portion of the probe body. The emission optical fiber defines a Numerical Aperture (NA). The tissue detection system further includes an emitter configured to output electromagnetic radiation and an optical coupler optically coupling the emitter with the input end of the emission optical fiber such that, in response to receiving the output from the emitter, electromagnetic radiation is input to the input end of the emission optical fiber. The optical coupler modifies the electromagnetic radiation such that the electromagnetic radiation input to the input end of the emission optical fiber defines an NA about equal to or less than the NA of the emission optical fiber.Type: GrantFiled: September 27, 2021Date of Patent: May 7, 2024Assignee: AI Biomed Corp.Inventors: Adnan S. Abbas, Nicholas F. Pergola
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Patent number: 11970527Abstract: The present disclosure is directed to a monoclonal antibody, or antigen-binding fragment thereof, that specifically binds to a Staphylococcus aureus clumping factor A protein (ClfA), as well as compositions comprising the monoclonal antibody. The disclosure also is directed to methods of treating a Staphylococcus aureus infection by administering the anti-ClfA monoclonal antibody alone, or in combination with a monoclonal antibody that specifically binds to S. aureus alpha toxin (AT) protein to a subject. Bispecific monoclonal antibodies that specifically bind to both ClfA and AT and methods of using the same also are provided.Type: GrantFiled: September 23, 2021Date of Patent: April 30, 2024Assignees: MedImmune, LLC, Humabs BioMed SAInventors: Christine Tkaczyk, Bret Sellman, Martin Borrok, III, Davide Corti, Andrea Minola
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Publication number: 20240132603Abstract: Involved is an isolated antigen binding protein, being capable of binding CCR8 derived from a primate animal. Further involved are a pharmaceutical composition comprising the antigen binding protein, and an application of the antigen binding protein and/or the pharmaceutical composition in the prevention and/or treatment of a tumor or a cancer.Type: ApplicationFiled: August 26, 2021Publication date: April 25, 2024Applicant: HARBOUR BIOMED US, INC.Inventors: Shuang LU, Yongqiang WANG, Xin GAN, Fei CHEN, Jinqiu HE, Xiaohui SHAO, Shaoping HU, Chuchu ZHAO, Jiuqiao ZHAO, Yiping RONG
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Publication number: 20240130714Abstract: Disclosed are computer-implemented or computer-aided method for diagnosing or predicting the risk of obstructive sleep apnea in a subject. The methods comprise determining whether the subject has obstructive sleep apnea based on at least one quantitative ultrasound parameter and/or at least one morphometric parameter.Type: ApplicationFiled: May 16, 2023Publication date: April 25, 2024Applicant: AMCAD BIOMED CORPORATIONInventors: Argon CHEN, Yi-li LEE, Pei-Yu CHAO, Wei-Hao CHEN, Wei-Yu HSU
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Patent number: 11937897Abstract: Devices and methods for visibly highlighting areas of a region including an imager configured to image the region with a sensitivity to at least one of wavelength, light level, or contrast greater than the human eye, an overlay element configured to visibly highlight areas of the region and registered to the imager to produce alignment of imaged features with highlighted features at the same location on the region, and at least one of a controller executing a program or logic configured to process acquired images from the imager to identify areas of the region determined not visible to the human eye, and control the overlay element to visibly highlight those areas on the region.Type: GrantFiled: June 24, 2022Date of Patent: March 26, 2024Assignees: AI Biomed Corp, Vanderbilt UniversityInventors: Adnan Abbas, Melanie McWade, Anita Mahadevan-Jansen
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Patent number: 11932682Abstract: The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus.Type: GrantFiled: October 21, 2021Date of Patent: March 19, 2024Assignees: MEDIMMUNE, LLC, HUMABS BIOMED SAInventors: Ebony Benjamin, Nicole Kallewaard-LeLay, Josephine Mary McAuliffe, Frances Palmer-Hill, Leslie Wachter, Andy Yuan, Qing Zhu, Davide Corti, Antonio Lanzavecchia, Barbara Guarino, Anna DeMarco
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Patent number: 11926658Abstract: The invention relates to multispecific antibodies, and antigen binding fragments thereof, that specifically bind to distinct Zika virus epitopes and potently neutralize infection of ZIKV. The invention also relates to nucleic acids that encode such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in prophylaxis and treatment of ZIKV infection.Type: GrantFiled: August 31, 2018Date of Patent: March 12, 2024Assignee: HUMABS BIOMED SAInventor: Davide Corti
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Patent number: 11912757Abstract: The invention relates to antibodies, and antigen binding fragments thereof, that potently neutralize infection of ZIKV. The invention also relates to antigenic sites to which the antibodies and antigen binding fragments bind, as well as to nucleic acids that encode and immortalized B cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of ZIKV infection.Type: GrantFiled: June 1, 2021Date of Patent: February 27, 2024Assignee: HUMABS BIOMED SAInventor: Davide Corti
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Publication number: 20240050583Abstract: The present application relates to a protein-drug conjugate, containing an antigen binding protein portion and a drug conjugate portion. The antigen binding protein portion comprises one or more antigen binding fragments, and at least two linker peptides are directly or indirectly connected to the antigen binding fragments. The two linker peptides can each independently contain a first cysteine Cys1 and a second cysteine Cys2. The drug conjugate portion is covalently bonded on Cys1. The present application further relates to a preparation method for the protein-drug conjugate, and a use for the protein-drug conjugate in preventing or treating tumors or other diseases.Type: ApplicationFiled: March 25, 2021Publication date: February 15, 2024Applicant: HARBOUR BIOMED (SHANGHAI) CO., LTDInventors: Yun HE, Lei SHI, Yang CAO, Ming WANG, Yun ZHANG
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Patent number: 11851498Abstract: Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.Type: GrantFiled: March 9, 2020Date of Patent: December 26, 2023Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, BioMed Valley Discoveries, Inc.Inventors: Dimiter S. Dimitrov, Zhongyu Zhu, Bradley St. Croix, Steven Seaman, Saurabh Saha, Xiaoyan Michelle Zhang, Gary A. DeCrescenzo, Dean Welsch
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Patent number: 11852577Abstract: The present technology relates to systems and associated methods for measuring properties of particles in a solution. In one or more embodiments, a particle measurement system is configured to generate a reference signal, communicate the reference signal across a plurality of resistors and overlapping pairs of electrodes that define detection regions for particulates traveling through a microchannel, and measure various properties of the particles based on detecting changes in the communicated reference signal.Type: GrantFiled: December 9, 2022Date of Patent: December 26, 2023Assignee: ORANGE BIOMED LTD., CO.Inventors: Ung Hyeon Ko, Seung Jin Kang, Eun Young Park
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Patent number: 11844361Abstract: A composition for human consumption that combines various ingredients that boost stem cell activity. Illustrative ingredients may for example include high cacao content chocolate, medicinal mushroom extracts, substances containing or promoting DHEA, pine bark extract to convert arginine from cacao into nitric oxide to improve circulation. DHEA boosting substances may include truffle powder and/or pine pollen. An illustrative composition may have about 75% chocolate by weight, with cacao content of 73% or more, at least 10% truffle powder or pine pollen, at least 10% medicinal mushroom extracts, the remainder pine bark extract. The composition may be formulated into sublingual tablets of about 1 gram, and daily consumption may for example consist of 5 tablets for 5 grams total. Includes a method of supporting cardiovascular health, improving sexual performance and sexual health, and improving athletic performance by administering a therapeutic amount of the compound to a subject.Type: GrantFiled: April 8, 2021Date of Patent: December 19, 2023Assignee: WIPARO BIOMED LIMITEDInventor: David Schmidt
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Patent number: 11819193Abstract: A tissue detection system and methods for use thereof are provided. The tissue detection system facilitates stimulating fluorescence via illumination in an area or areas of interest in the human body, detecting non-visible or not easily visible areas of interest subject to such stimulation, and identifying these areas of interest efficiently. The tissue detection system can employ a probe for facilitating illumination/stimulation of a tissue of interest, at least one emitter for generating radiation applied to the tissue of interest, and at least one detector for capturing radiation for the fluorescing tissues of interest.Type: GrantFiled: March 24, 2020Date of Patent: November 21, 2023Assignee: AI Biomed Corp.Inventors: Adnan Abbas, Roshan Shetty
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Publication number: 20230357425Abstract: Provided an isolated antigen binding protein having one or more of the following properties: a. capable of binding to both human CD73 and Cynomolgus monkey CD73; b. capable of inhibiting 5?ectonucleotidase activity of CD73; c. capable of mediating CD73 internalization; d. capable of promoting T cell proliferation; e. with a relatively stable concentration in serum; and f. capable of inhibiting tumor growth and/or tumor cell proliferation. In addition, provided a method for producing the isolated antigen binding protein as well as pharmaceutical uses of the isolated antigen binding protein in preventing, alleviating and/or treating tumor.Type: ApplicationFiled: August 20, 2020Publication date: November 9, 2023Applicant: Harbour BioMed (Shanghai) Co., LtdInventors: Lei SHI, Xin GAN, Qianqian SHAN, Yiping RONG, Yun HE
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Publication number: 20230346867Abstract: Embodiments include a well spray used when first awakening, and then again before exercise. Embodiments produce a very noticeable increase in strength and stamina in the gym. Another embodiment includes an evening spray that helps a user feel sleepy after about 10 minutes, wherein the quality of sleep is longer and deeper.Type: ApplicationFiled: May 2, 2023Publication date: November 2, 2023Applicant: WIPARO BIOMED LIMITEDInventor: David SCHMIDT
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Patent number: 11787853Abstract: The invention relates to antibodies and antigen binding fragments thereof that are capable of binding to influenza B virus hemagglutinin (HA) and neutralizing influenza B virus in two phylogenetically distinct lineages. In one embodiment, the antibody or antigen binding fragment is capable of binding to influenza B virus hemagglutinin and neutralizing influenza B virus in Yamagata and Victoria lineages.Type: GrantFiled: October 12, 2021Date of Patent: October 17, 2023Assignees: MEDIMMUNE, LLC, HUMABS BIOMED SAInventors: Nicole Kallewaard-Lelay, Qing Zhu, Ebony Benjamin, Leslie Wachter, Andy Yuan, Josephine Mary Mcauliffe, Davide Corti, Antonio Lanzavecchia
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Publication number: 20230322953Abstract: Disclosed is a binding protein having at least two protein functional regions, the binding protein comprising a protein functional region A and a protein functional region B; the protein functional region A and the protein functional region B target different antigens or epitopes, the protein functional region A is a Fab or a scFv structure, the protein functional region B is a VH structure, and there are one or more of each of the protein functional region A and the protein functional region B. A multi-specific binding protein has a smaller molecular weight, fewer polypeptide chains, and a simpler structure. By means of different structure types, relative positions, binding valence and other parameters, the functional activities for different targets can be adjusted, and then different combinations of activities can be designed so as to meet the needs of different dose combinations of clinical combinations.Type: ApplicationFiled: June 29, 2021Publication date: October 12, 2023Applicant: HARBOUR BIOMED (SHANGHAI) CO., LTDInventors: Yun HE, Lei SHI, Haishan LUO, Qiang LV, Jinqiu HE, Zenglin PEI, Yongqiang WANG, Chen ZHONG, Bing HUANG, Jianxun ZHAO, Xingxing JIA, Xuekun ZHANG, Chuchu ZHAO, Fei CHEN, Lei NIU
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Publication number: 20230321800Abstract: Screw, screwdriver and screw fastening set, the screwdriver (1) comprising a screw engaging configuration (10) with a core (11) surrounded by a number of protruding longitudinal ribs (12) elongated in the longitudinal driver axis (DA) direction and radially distributed around the core (11) in radial symmetry, and wherein successive transversal cross-sections of the core (11), perpendicular to the longitudinal driver axis (DA), have a regular polygonal shape, longitudinal cross-sections of the core (11), coincident with the longitudinal driver axis (DA), have a convex shape, and each protruding longitudinal rib (12) is connected to the core (11) on an edge between two adjacent arched convex surfaces of the core, a central portion (13) of each side of the regular polygonal shape being exposed for coupling into a complementary flat surface of a driver engaging configuration of the screw, providing friction-retention between the screw and the screwdriver.Type: ApplicationFiled: March 28, 2023Publication date: October 12, 2023Applicant: Bonastre Biomed, SLInventor: Sergi Martinez Roig