Abstract: The preparation of vitamin D compounds of formula (I) with a label attached to a spacer group in the 3 position is disclosed. In the above formula (I), O represents the oxygen atom of an ether group; Y represents hydrogen or hydroxy; A represents a label such as biotin, digoxigenin, or another vitamin D group; R represents a substituted hydrocarbon side-group of vitamin D or a vitamin D metabolite. Also disclosed is a method of measuring 25-hydroxy vitamin D metabolite and a 1?,25-dihydroxy vitamin D metabolite in a sample.
Type:
Grant
Filed:
March 3, 2004
Date of Patent:
March 13, 2012
Assignees:
Immundiagnostik AG, Biomedica GmbH
Inventors:
Franz Paul Armbruster, Wolfgang Voelter, Jens Tampe, Christian Birkmayer
Abstract: Vitamin D compounds of formula (I) with a label attached to a spacer group in the 3 position are disclosed.
In the above formula (I), X is an optionally substituted hydrocarbon group with a length of 0.8-4.2 nm, optionally containing the heteroatoms S, O, N or P; Y is H or OH; A is a label capable of binding with high affinity to a protein; R is an optionally substituted hydrocarbon side chain of a D vitamin or a D vitamin metabolite. Also disclosed is the preparation of formula (I).
Type:
Grant
Filed:
February 20, 2001
Date of Patent:
September 7, 2004
Assignees:
Immundiagnostik AG, Biomedica GmbH
Inventors:
Franz Paul Armbruster, Wolfgang Voelter, Jens Tampe, Christian Birkmayer
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