Abstract: The invention relates to polysaccharides, polysaccharide conjugates with altered biological properties, and methods to produce these polysaccharides and conjugates.
Type:
Grant
Filed:
August 1, 2000
Date of Patent:
November 12, 2002
Assignee:
Biomedical Frontiers, Inc.
Inventors:
Bo E. Hedlund, Thomas P. Weber, Paul R. Dragsten, Gregory J. Hanson, Philip E. Hallaway
Abstract: The invention relates to fluid resuscitation of the human or animal body by administration of deferoxamine (DFO) and a water-soluble biopolymer.The DFO and the biopolymer are preferably bonded together.The biopolymer may be a polysaccharide or a protein.The DFO and the biopolymer are preferably formulated as an aqueous solution suitable for oral administration.The fluid resuscitation may be effected for ameliorating systemic oxidant injury occurring during ischemia and subsequent reperfusion.The fluid resuscitation may be indicated in treatment of burn injury, lung injury caused by inhalation of hot and/or toxic substances, such as smoke derived from combustion, hemorrhagic shock and other types of trauma.
Abstract: Compositions comprising a covalently bounded adduct of deferoxamine, ferric iron and polymer for image enhancement in magnetic resonance (MR) imaging are provided. A pharmaceutical composition comprising the adduct and method of using the composition in magnetic resonance imaging are also disclosed.
Abstract: A method for scavenging free iron or aluminum in fluids such as physiological fluids involves a provision in such fluids of a soluble polymer substrate having chelator immobilized thereon. According to the invention preferred such compounds comprise polysaccharides or proteins having a deferoxamine moiety thereon. Such a compound can be used for the treatment of iron overload, as well as to inhibit cell damage from oxidation/reduction reactions. In one embodiment, cell damage during reperfusion is inhibited, through provision of the chelating moiety at the site of reperfusion.
Type:
Grant
Filed:
June 17, 1991
Date of Patent:
June 8, 1993
Assignee:
Biomedical Frontiers, Inc.
Inventors:
Bo E. Hedlund, Philip E. Hallaway, Samuel S. Panter, John W. Eaton
Abstract: A method for scavenging free iron or aluminum in fluids such as physiological fluids involves a provision in such fluids of a soluble polymer substrate having chelator immobilized thereon. According to the invention preferred such compounds comprise polysaccarides or proteins having a deferoxamine moiety thereon. Such a compound can be used for the treatment of iron overload, as well as to inhibit cell damage from oxidation/reduction reactions. In one embodiment, cell damage during reperfusion is inhibited, through provision of the chelating moiety at the site of reperfusion.
Type:
Grant
Filed:
August 20, 1987
Date of Patent:
September 5, 1989
Assignee:
Biomedical Frontiers, Inc.
Inventors:
Bo E. Hedlund, Philip E. Hallaway, Samuel S. Panter, John W. Eaton