Patents Assigned to Biomedical, Inc.
  • Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative
    Patent number: 9227962
    Abstract: Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, R1 is optionally substituted heteroaryl etc.; R2 is hydrogen etc.; R3 and R4 are each independently hydrogen etc., R5 is the following group: (wherein Y is optionally substituted five membered heteroaryl etc., R9a is optionally substituted aryl etc., R9b and R9c are each dependently hydrogen etc., and m is the integral 0 etc.) etc.; R6 is hydrogen etc.; and R7 is hydrogen etc.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 5, 2016
    Assignee: Boston Biomedical, Inc.
    Inventors: Katsunori Tsuboi, Yosuke Takanashi, Shingo Tojo, Tomohiro Kodama, Katsumi Kubota, Toshio Kanai
  • CELL SORTING SYSTEM USING MICROFABRICATED COMPONENTS
    Publication number: 20150367346
    Abstract: A MEMS-based cell sorter is disclosed, which uses a novel combination of features to accomplish the cell sorting using a microfabricated cell sorting valve housed in a disposable cartridge. The features include an interposer that provides fluid communication between the microfluidic passages in the silicon substrate and a plurality of fluid reservoirs in the cartridge, including a sample, sort and waste reservoir The disposable cartridge may include other features that assist in the handling of small volumes of fluids, such as a siphon region in the sort reservoir and funnel-shaped regions in the sample and waste reservoirs. A mixing mechanism may be provided for stirring the contents of the sample reservoir.
    Type: Application
    Filed: March 4, 2015
    Publication date: December 24, 2015
    Applicant: Owl biomedical, Inc.
    Inventors: John S. FOSTER, Nicholas C. Martinez, Daryl Grummitt, Ralf-Peter Peters, Christian Peth, Markus Nagel
  • Variable gear ratio ratchet
    Patent number: 9216496
    Abstract: This invention relates to a fastener driving device including a variable ratio gear mechanism that enables the ratio of the rotation of the handle to the rotation of a driving bit extending from the handle to be varied to allow the bit to rotate at different speeds from the handle. The device includes a gear mechanism disposed within a housing for the device that includes a locking member. The locking member can be engaged with the gear mechanism to lock the gear mechanism in a configuration for a 1:1 gear ratio. The locking member can be moved with regard to the gear mechanism to provide an increased gear ratio for the gear mechanism when desired.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: December 22, 2015
    Assignee: Gauthier Biomedical, Inc.
    Inventors: Michael T. Gauthier, Mara C. Schwartz, Robert F. Miller
  • Bone graft
    Patent number: 9211360
    Abstract: A method for producing a bone matrix scaffold has the steps of providing at least one sheet material and cross-linking the at least one sheet material using fibers. The sheet material has a surface pattern that enhances osteo-conductivity and potentially supports inductivity. The surface pattern is a 3-dimensional substantially continuous network having voids. The combination of the at least one sheet and fibers form a macrostructure having substantially continuous network and voids.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: December 15, 2015
    Assignee: Vivex Biomedical, Inc.
    Inventor: Timothy Ganey
  • TISSUE ALLOGRAFT STERILIZATION METHOD
    Publication number: 20150352235
    Abstract: The invention is a novel method of sterilizing bone and soft tissues intended for human transplantation. In one embodiment the process includes steps of subjecting transplants to high hydrostatic pressures of aqueous fluid to which chlorhexidine gluconate or similar sterilizing chemicals have been added.
    Type: Application
    Filed: June 10, 2014
    Publication date: December 10, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventor: Theodore I. Malinin
  • Dynamic Biometric Mesh
    Publication number: 20150351889
    Abstract: A dynamic biometric mesh (10) has a plurality of radial members (30) and a plurality of catenaries (20). Each catenary (20) extends between and is fixed to at least one pair of adjacent radial members (30). The plurality of catenaries (20) and radial members (30) form a low mass structural system arranged in an architecture configured to be structurally stable in tension and pliable for deployment and integration with biologic tissue.
    Type: Application
    Filed: June 4, 2015
    Publication date: December 10, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventors: P. Pravin Reddy, Timothy Ganey
  • Method and system for manual and autonomous control of an infusion pump
    Patent number: 9205192
    Abstract: A method and system for both autonomous and manual control of an infusion pump for delivering medication to a patient is provided.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: December 8, 2015
    Assignee: Bigfoot Biomedical, Inc.
    Inventors: Mark C. Estes, Mitchell Wenger, Morten Mernoe, James Causey
  • Method For Production Of Large Numbers Of Cartilage Cells With Phenotype Retention
    Publication number: 20150344847
    Abstract: A method for production of large numbers of cartilage cells with phenotype retention intended for treatment of articular cartilage lesions or preparing viable cartilage tissue by propagation of chondrocytes from cartilage explants, human or animal, with the retention of phenotypes of the cartilage cells, in which cells are chondrocytes retaining morphologic attributes of the same or chondrocyte progenitor cells. The method includes culturing the cells in which cultured cells are organized into mature hyaline cartilage on the surface of biologic structures such as cancellous or cortical bone lamina. The method for culturing chondrocytes to produce three dimensional cellular structures consisting of cartilage cells and cell produced extracellular cartilage matrix.
    Type: Application
    Filed: May 29, 2014
    Publication date: December 3, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventor: Theodore I Malinin
  • ECG signal acquisition device
    Patent number: 9198589
    Abstract: An ECG data acquisition device is provided, including a main housing, at least two electrodes, an ECG signal acquisition circuitry having a processor and a memory for storing acquired data, a connector for communication, and a movable housing, covering the connector and having at least an electrode mounted thereon, wherein as executing the ECG signal acquisition, the movable housing is in a first state, and as communicating with an external equipment, the movable housing is moved to a second state for exposing the connector and electrically disconnecting the electrode thereon from the ECG signal acquisition circuitry.
    Type: Grant
    Filed: September 17, 2010
    Date of Patent: December 1, 2015
    Assignee: MD Biomedical, Inc.
    Inventor: Chang-An Chou
  • Polymeric implant delivery system
    Patent number: 9198783
    Abstract: Delivery systems for a polymeric tubular implant, kits that include such delivery systems, and methods of treating patients by implanting tubular implants using the delivery systems. The delivery systems include an inner shaft, an expandable member slidably disposed about the inner shaft and configured to receive the tubular implant, and a tubular outer shaft disposed about the inner shaft.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: December 1, 2015
    Assignee: 480 Biomedical, Inc.
    Inventors: Nareak Douk, Rany Busold, Lee Core, Kicherl Ho, My Le, Timothy Walter Robinson, Sarah Kostanski, Benedict Shia, Jerry Brightbill
  • Particle manipulation system with cytometric capability
    Patent number: 9194786
    Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: November 24, 2015
    Assignee: Owl biomedical, Inc.
    Inventors: John S. Foster, Daryl W. Grummitt
  • SPINAL IMPLANTS WITH STEM CELLS
    Publication number: 20150328011
    Abstract: A spinal implant device has a synthetic or metallic or a combination thereof of these materials in an implant body structure and stem cells in a coating, or a sheet, wrap or a membrane wrap applied to surfaces on the implant body structure or alternatively filled with a plug of stem cell laden material. The implant body structure preferably has an aperture or channel. The spinal implant device may include anchoring holes to secure the device to the spinal skeletal structure with fasteners or alternatively can simply be held in place by and between adjacent vertebrae.
    Type: Application
    Filed: July 29, 2015
    Publication date: November 19, 2015
    Applicant: VIVEX BIOMEDICAL INC.
    Inventors: Alan Davenport, Tracy Scott Anderson, Jeffrey Scott Radcliffe
  • Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof
    Patent number: 9187454
    Abstract: The invention provides novel inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, and methods of making such compounds and compositions.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 17, 2015
    Assignee: Boston Biomedical, Inc.
    Inventors: Chiang Jia Li, Ji-Feng Liu, Wei Li, Amanda Gibeau, Harry Rogoff
  • Embolic protection during percutaneous heart valve replacement and similar procedures
    Patent number: 9186237
    Abstract: Various devices are described to provide filtering of flow from the aorta to the left carotid artery and the right carotid artery. The filters can be brought into a desired position through one or more peripheral arteries. A single filter device can provide the desired filtering or a plurality of devices can be used. In particular a single filter device can span between the brachiocephalic artery and the left carotid artery. These filter devices can be used effectively to capture emboli generated during procedures on the heart so that emboli do not travel to the patient's brain where the emboli can cause a stroke or other adverse event. In particular, these filters can be used during percutaneous procedures on the heart, such as endovascular heart valve replacement.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: November 17, 2015
    Assignee: Lumen Biomedical, Inc.
    Inventors: Jason A. Galdonik, Matthew F. Ogle, Edward Anderson, Mark W. I. Webster
  • Bilirubin Hematofluorometer and Reagent Kit
    Publication number: 20150323460
    Abstract: A hematofluorometer an excitation source configured to generate an excitation beam, a fluorescence detector configured to a fluorescence beam, and a housing configured to receive a reagent kit for detecting bilirubin in a fluid sample. The reagent kit includes a body defining at least one fluid receiving well and an optical window positioned over each at least one fluid receiving well and a light passage window opposite each optical window. Each window is formed of a material having a fluorescence intensity that is of a lower magnitude than the fluorescence to be detected from the bilirubin. A light sensor within the housing is configured to detect light passing through the reagent kit.
    Type: Application
    Filed: July 22, 2015
    Publication date: November 12, 2015
    Applicant: AVIV BIOMEDICAL, INC.
    Inventors: Jack Aviv, Angelo A. Lamola, Glen Ramsay, Jeff MacDonald
  • Bone screw fastener
    Patent number: 9179954
    Abstract: An improved bone screw for humans or mammals is a bone screw having exposed surfaces along a shank and threads extending from the shank with one or more selected portions of the exposed surfaces having a 3-dimensional pattern. The pattern provides enhanced resistance to thread loosening when affixed to bone. The exposed surface is on exterior portions of the threads or portions of the shank or both. The one or more selected portions of the exposed portions having a bone formation enhancing 3-dimensional patterns are in the external exposed thread surfaces or in the exposed shank surfaces or both.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: November 10, 2015
    Assignee: Vivex Biomedical, Inc.
    Inventor: Timothy Ganey
  • Apparatus and methods for ocular injection
    Patent number: 9180047
    Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: November 10, 2015
    Assignee: Clearside Biomedical, Inc.
    Inventors: Rafael Victor Andino, Vladimir Zarnitsyn, Christopher John Brooks, Jesse Yoo
  • Particle manipulation system with cytometric confirmation
    Patent number: 9168568
    Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the valve. By reversing the flow from output to input, the same laser interrogation region may be used to perform the cytometry. The cytometry may be performed throughout the sorting process to optimize or control the sorting, or may be performed afterward to allow a multi-pass, sequential sort to be performed on the same sample.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: October 27, 2015
    Assignee: Owl biomedical, Inc.
    Inventors: John S Foster, Nicholas C. Martinez, Kevin E. Shields, Jaquelin K. Spong
  • Lubricant Regulating Agent
    Publication number: 20150299600
    Abstract: The present invention makes the insertion perception during actual surgery to be equivalent to the insertion perception of a catheter into a blood vessel model when water is used as the circulating fluid. A lubricant regulating fluid primarily composed of water is mixed with an aqueous metal salt and a surfactant as a lubricant regulating agent of the lubricant regulating fluid. A cationic surfactant, an anionic surfactant, a nonionic surfactant, or a dipolar ionic surfactant may be used as the surfactant. Also, the metal salt may be an alkaline metal salt, an alkaline earth metal salt, an aluminum salt, a ferric salt, or the like. In an example, the lubricant regulating fluid obtained by mixing an aqueous metal salt with water is prepared, and the lubrication and non-adherent properties of a catheter into a simulated blood vessel model are improved.
    Type: Application
    Filed: February 24, 2012
    Publication date: October 22, 2015
    Applicant: FAIN-BIOMEDICAL INC.
    Inventor: Seiichi Ikeda
  • Drug eluting medical implant
    Patent number: 9155638
    Abstract: Disclosed are self-expanding medical implants for placement within a lumen of a patient. The implants comprise a woven or non-woven structure having a substantially tubular configuration, and are designed to be low-profile such that they are deliverable with a small diameter catheter. The implants have a high recoverability and desired mechanical properties.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: October 13, 2015
    Assignee: 480 BIOMEDICAL, INC.
    Inventors: Maria Palasis, Changcheng You, Danny Concagh, Lee Core, Kicherl Ho, Upma Sharma, Gregory T. Zugates