Abstract: The present invention relates to dietary supplements. In particular, the present invention provides compositions and methods utilizing dietary supplements comprising fungus and bacteria co-culture growth media. In preferred embodiments, the bacteria is Gluconacetobacter europaeus or Bacillus pumilus or a combination thereof and the fungus is Zygosaccharomyces. The microorganisms are preferably substantially removed from the growth media. In preferred embodiments, the growth media is dried down, lyophilized, or spray dried to provide a powder.