Patents Assigned to bioMerieus B.V.
  • RNA polymerase mutants with increased thermostability
    Patent number: 7507567
    Abstract: The present application relates to mutated RNA polymerases from bacteriophages that have increased stability, for example under high temperature conditions. Preferred mutated RNA polymerases according to the invention are mutant RNA polymerases from T7 or SP3 bacteriophages. An especially preferred embodiment of the present invention is a T7 RNA polymerase with a serine to proline amino acid change in the protein at position 633 of the amino acid sequence.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: March 24, 2009
    Assignee: bioMerieus B.V.
    Inventors: Akio Sugiyama, Yoshiaki Nishiya, Bunsei Kawakami