Abstract: Methods of stimulating collagen production, including stimulation of chondrocyte production, at the site of a defect. Methods include administering to the site of a defect at least two proteins from the group IL-1ra, sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII.

Abstract: An anchoring system includes an anchor including an anchor body and a distal member located at a distal end of the anchor body, the distal member having a suture receiving aperture; and an implant delivery device, comprising: a cannulated outer shaft, the cannulated outer shaft configured to engage a proximal end of the anchor body for driving the anchor into a bore; and an inner shaft slidably received in the cannulated outer shaft, wherein a distal end of the inner shaft is extendable distally beyond a distal end section of the cannulated outer shaft such that, when the cannulated outer shaft is engaging the proximal end of the anchor body, the distal end of the inner shaft is extendable through the anchor body to a distance beyond the distal end of the anchor body to engage a suture located within the suture receiving aperture, wherein the anchoring system is configured such that the suture can be tensioned at a location within the bore distal from the anchor body before the anchor body is implanted within

Abstract: Systems and methods may use an augmented reality device during a surgical procedure. The systems and methods may use an augmented reality display of an augmented reality device to present or project a virtual feature during a surgical procedure while permitting physical aspects of a surgical field to be viewed through the augmented reality display. The virtual feature may include aspects of a preoperative plan, a surgical device, an anatomical aspect of a patient, etc.

Abstract: A plate assembly for attaching a bone flap to a skull is provided and may include a first plate member attached to the bone flap and a second plate member supported by the first plate member and movable between a retracted position and an extended position relative to the first plate member. The second plate member may be removed from a cut line between the bone flap and the skull in the retracted position and may extend over the cut line in the extended position.

Abstract: Described herein are examples of orthopedic drill bits and methods of preparing a bone of a living being for fixation. An example method includes coupling a drive attachment of a drill bit to a mounting attachment of a driver, and placing a guide at a desired location on the bone. The guide has an opening corresponding to an area of bone to be removed. The guide provides proper positioning and alignment for drilling a hole. With the guide in place, the method further includes aligning the drill bit with the opening on the guide and drilling a hole in the bone. Once the hole is drilled, the method includes de-coupling the drill bit from the driver, and bending the drill bit at the drive attachment while the drill bit is still in the bone. In some examples, additional method steps follow preparation of the hole.

Abstract: Disclosure herein are knotless suture anchor constructs and methods of use thereof. The suture anchor constructs can include a bone anchor and a suture. The bone anchor can include a suture anchoring member and can define a cavity and a longitudinal passage extending from a trailing end of the bone anchor at least partially therethrough to the cavity. The suture anchoring member can be located in the cavity. The suture can be coupled to the suture anchoring member and can include a tensioning portion, a repair portion, and an intermediate portion. The intermediate portion can form a suture loop extending along the longitudinal passage.

Abstract: A glenoid implant comprises a body comprising: an articular surface and a scapula-engaging surface, the scapula-engaging surface including first and second portions angled relative to each other; and a fixation feature extending from the scapula-engaging surface. A method comprises: forming a planar bone surface at a glenoid using a guide pin; forming a first bore into the glenoid located near the guide pin; forming a second bore into the glenoid offset from the first bore; inserting an augment ream guide into the first and second bores; and forming an angled bone surface at the glenoid relative to the planar bone surface using the augment ream guide. A ream guide comprises: a base having first and second surfaces; a bone peg extending from the first surface; an alignment peg spaced from the bone peg; and a guide peg extending from the second surface at an oblique angle to the bone peg.

Abstract: A humeral cut guide member for resectioning or resurfacing a humeral head, including a bone-engagement member including a first patient-specific bone-engagement surface that is complementary and made to substantially mate and nest in only one position on a specific patient's humeral head; a registration member connected to the bone-engagement member including a second patient-specific bone engagement surface that is sized and made to substantially mate and nest in only one position with the specific patient's bicipital groove; and a cut guide plate connected to the bone-engagement member and defining an elongated slot.

Abstract: An instrumentation set for preparing a proximal tibia during a bi-cruciate retaining procedure can include a tibial resection block and a stylus. The tibial resection block can be configured to be fixed to an anterior portion of the proximal tibia. The tibial resection block can define a slot that extends in a medial-lateral direction when the tibial resection block is fixed to the proximal tibia. The stylus can have a first block attachment feature and a second block attachment feature. The first block attachment feature can be offset from the stylus a first distance. The second block attachment feature can be offset from the stylus a second distance. The first and second block attachment features of the stylus can be selectively and alternatively received by the slot of the tibial resection block to position the stylus at distinct offset locations relative to the slot.

Abstract: A failsafe for a transdermal apparatus for a prosthetic appendage can include a first plate, a second plate, and a breakaway connector. The first plate can have a central axis, a proximal portion, and a distal end. The distal end can be opposite the proximal portion, and the distal end can be securable with a prosthetic external to skin and can be configured to simulate an appendage of a patient. The second plate can be aligned with the central axis and can include a proximal end and a distal portion. The proximal end can be securable to a transdermal implant, and can extend proximally from the second plate. The distal portion can be opposite the proximal end, and the distal portion can be configured to interface with the proximal portion of the first plate. The breakaway connector can be couplable within the second plate and the first plate.

Abstract: A self-adjusting suture construct can include a suture extending from a passive end to an active end. The passive end can include a first loop that the active end can be passed through to form a second loop. The active end can then be pulled to tighten the second loop around a portion of a patient's anatomy. The active end can be passed through an anchor and the anchor can be implanted to lock the tightened second loop.

Abstract: Example implants, systems and methods using sensors for orthopedic surgical assessment and/or planning are described herein. An example system can include a wearable sensor device for pre-operative use by a patient before an orthopedic surgery to generate pre-operative sensor data. The system can also include an implantable sensor device (e.g., a bone implant) to generate and aggregate post-operative sensor data associated with the patient after the surgery. The system can retrieve the pre-operative sensor data and the post-operative sensor data and predict, analyze or assess an outcome of the surgery.

Abstract: Methods and compositions generating and using an interleukin-1 receptor antagonist (IL-1ra)-rich solution. Methods for generating and isolating interleukin-1 receptor antagonist include incubating a liquid volume of white blood cells and platelets with polyacrylamide beads to produce interleukin-1 receptor antagonist. The interleukin-1 receptor antagonist is isolated from the polyacrylamide beads to obtain the solution rich in interleukin-1 receptor antagonist. Methods for treating a site of inflammation in a patient include administering to the site of inflammation the solution rich in interleukin-1 receptor antagonist.

Abstract: Disclose herein are suture anchor constructs. The suture anchor constructs can include an anchor, a first suture, and a second suture. The anchor can include a post and a body. The body can define a central hole extending from a trailing end of the body along a central axis towards a leading end of the body. The first suture can have a first tail, a second tail, and a first intermediate portion located proximate the post. The second suture can have a third tail, a fourth tail, and a second intermediate portion secured to the post. The first, second, third, and fourth, tails can pass through the central hole.

Abstract: Porous regions are formed using selected additive manufacturing techniques. The porous regions can assist in fibro-inductive regions and/or osteo-inductive regions. A prosthetic member can be formed completely with the additive manufacturing technique and/or the additive manufacturing techniques can be used to form an augment portion that is added to the prosthetic member formed separately.

Abstract: A method for preparing a femur for receiving a prosthesis. The method includes the following: fixing a femoral trial component to the femur; coupling a reamer bushing relative to the femoral trial component; reaming a cavity into the femur using the reamer bushing as a guide; coupling at least one of a modular femoral box trial and a stem adapter relative to the femoral trial component; trialing the femoral trial component with the articulating surface of the femoral trial component; and performing the coupling of the reamer bushing, the reaming of the cavity, the coupling of the at least one of the modular femoral box trial and stem adapter, and the trialing of the femoral trial component all while the femoral trial component remains fixed to the distal femur.

Abstract: A glenoid device for preparing a shoulder joint of a patient includes a reusable guide holder having a body between an upper surface and a lower surface and a bore passing through the body of the guide holder. The glenoid device also includes a patient-specific glenoid guide having a body with an upper and lower surface. The lower surface of the patient-specific glenoid guide is configured as a negative surface of a glenoid face based on preoperative image scans of the shoulder joint of the patient. The upper face of the patient-specific glenoid guide is configured to be coupled and contact the lower face of the guide holder, such that the bore of the guide holder is aligned along a patient-specific bore through the body of the patient-specific glenoid guide and along a corresponding alignment axis of the patient-specific glenoid guide.

Abstract: A patient-specific guide tool for guiding an object toward a glenoid face of a scapula of a patient for implantation of a shoulder prosthetic device is disclosed. The guide tool includes a guide portion that includes a guide surface. The guide surface is configured to guide movement of the object toward the glenoid face. Furthermore, the guide tool includes a patient-specific portion that is operably coupled to the glenoid portion. The patient-specific portion includes at least one patient-specific surface that is three-dimensionally contoured and that is configured to nest and closely conform to a corresponding surface of the scapula to thereby position the guide surface at a predetermined position relative to the glenoid face.

Abstract: The augments, systems and methods for supporting acetabular implants described herein can include an augment (100) for supporting an acetabular shell (90) having a first portion (136) of a locking mechanism. The system can also include a shell having a second portion of a locking mechanism (96). The first portion of the locking mechanism and the second portion of the locking mechanism can be adapted to move relative to one another from an unlocked state to a locked state to fixedly couple the augment to the shell. In some examples, the augment can be contourable to match the shape of a bone.

Abstract: A method of preparing a knee joint for a prosthesis in a patient includes mating a patient-specific three-dimensional curved inner surface of a femoral alignment guide onto a corresponding three-dimensional femoral joint surface of the patient. The patient-specific three-dimensional curved inner surface is preoperatively configured from medical scans of the knee joint of the patient. First and second holes are drilled into an anterior portion of the femoral joint surface through corresponding first and second guiding apertures of the femoral alignment guide.