Abstract: According to the present invention, there are provided a benzimidazole carbamate-sugar compound conjugate compound represented by the following Chemical Formula 1, a preparation method thereof, and a use thereof as an anti-cancer agent: Wherein, R1, R2, R3 and X are as defined in the specification and claims.
Abstract: The present disclosure provides an immunological composition for diagnosing lung cancer comprising: an antibody composition A containing an anti-CYFRA21-1 primary antibody-gene and an anti-CYFRA21-1 secondary antibody-detection marker; and an antibody composition B containing an anti-CYFRA 21-1 primary antibody-gene and an anti-human IgG antibody-detection marker; a method for diagnosing lung cancer in a human biological specimen using the same, and a diagnostic kit for lung cancer using the same. The composition for diagnosing lung cancer and the diagnostic method for lung cancer according to the present disclosure can diagnose the onset of lung cancer stages 0 to IV in a non-invasive biological specimen with a specificity of 90% or more and a sensitivity of 75% or more. In particular, since an autoantibody whose concentration increases rapidly in the early stage of lung cancer is used, it is possible to diagnose the onset of lung cancer stages 0 to 1 with a sensitivity of 76% or more.
Abstract: The present invention relates to a method of designing DNA probe chip for room-temperature hybridization in order to solve the solvent evaporation problem occurring when carrying out said hybridization at a high temperature of 40° C.˜50° C. or higher, wherein the method is designed to allow genotyping through hybridizing at a room temperature of 20° C.˜30° C. The method of designing DNA probe chip comprises designing DNA probe to start at ?10˜+5 position that is between ?10 position which is overlapped 10 sequences with primer and +5 position which is 5 sequences far from the 3?-terminal of primer, based on 0 position which is 3?-terminal of primer.
Type:
Grant
Filed:
November 7, 2008
Date of Patent:
October 22, 2019
Assignee:
BIOMETRIX TECHNOLOGY INC.
Inventors:
Tae Sun Kim, Keum Soo Song, Woon Yong Eoum, Chan Young Jung
Abstract: The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.
Type:
Grant
Filed:
July 27, 2011
Date of Patent:
August 6, 2013
Assignee:
Biometrix Technology Inc.
Inventors:
Tae Sun Kim, Keum Soo Song, Jung Hoon Kim, Hyung Sub Kim
Abstract: The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.
Type:
Application
Filed:
July 27, 2011
Publication date:
August 9, 2012
Applicant:
BIOMETRIX TECHNOLOGY INC.
Inventors:
Tae Sun Kim, Keum Soo Song, Jung Hoon Kim, Hyung Sub Kim
Abstract: The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.
Type:
Grant
Filed:
May 11, 2006
Date of Patent:
September 6, 2011
Assignee:
Biometrix Technology Inc.
Inventors:
Tae Sun Kim, Keum Soo Song, Jung Hoon Kim, Hyung Sub Kim
Abstract: The present invention relates to a method of designing DNA probe chip for room-temperature hybridization in order to solve the solvent evaporation problem occurring when carrying out said hybridization at a high temperature of 40° C.˜50° C. or higher, wherein the method is designed to allow genotyping through hybridizing at a room temperature of 20° C.˜30° C. The method of designing DNA probe chip comprises designing DNA probe to start at ?10˜+5 position that is between ?10 position which is overlapped 10 sequences with primer and +5 position which is 5 sequences far from the 3?-terminal of primer, based on 0 position which is 3?-terminal of primer.
Type:
Application
Filed:
November 7, 2008
Publication date:
August 13, 2009
Applicant:
BIOMETRIX TECHNOLOGY INC.
Inventors:
Tae Sun Kim, Keum Soo Song, Woon Yong Eoum, Chan Young Jung