Patents Assigned to BioMimetic Therapeutics, LLC
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Patent number: 11571497Abstract: A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.Type: GrantFiled: July 15, 2016Date of Patent: February 7, 2023Assignee: BioMimetic Therapeutics, LLCInventor: Samuel E. Lynch
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Patent number: 11364325Abstract: A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.Type: GrantFiled: July 15, 2016Date of Patent: June 21, 2022Assignee: BioMimetic Therapeutics, LLCInventor: Samuel E. Lynch
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Patent number: 11318230Abstract: A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.Type: GrantFiled: July 15, 2016Date of Patent: May 3, 2022Assignee: BIOMIMETIC THERAPEUTICS, LLCInventor: Samuel E. Lynch
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Patent number: 11235030Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).Type: GrantFiled: October 15, 2019Date of Patent: February 1, 2022Assignee: BioMimetic Therapeutics, LLCInventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
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Patent number: 11135341Abstract: The invention provides compositions and methods for treatment of tendon and ligament injuries and/or repair of damaged tendons and ligament. The invention provides compositions comprising a biocompatible matrix and platelet-derived growth factor (PDGF).Type: GrantFiled: August 9, 2019Date of Patent: October 5, 2021Assignee: BioMimetic Therapeutics, LLCInventors: Samuel E. Lynch, Leslie Wisner-Lynch, Hans K. Kestler, Yanchun Liu
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Patent number: 11058801Abstract: The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and/or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.Type: GrantFiled: September 14, 2015Date of Patent: July 13, 2021Assignee: BioMimetic Therapeutics, LLCInventors: Charles E. Hart, Samuel E. Lynch, Conan S. Young, Dan Perrien
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Patent number: 10493130Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).Type: GrantFiled: March 31, 2017Date of Patent: December 3, 2019Assignee: BIOMIMETIC THERAPEUTICS, LLCInventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
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Patent number: 10456450Abstract: The present invention provides compositions and methods for attaching tendon to bone. The present invention provides compositions and methods for treating rotator cuff injuries. In one embodiment, a method for treating rotator cuff injuries comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to at least one site of tendon reattachment on the humeral head.Type: GrantFiled: June 13, 2018Date of Patent: October 29, 2019Assignee: BIOMIMETIC THERAPEUTICS, LLCInventors: Charles E. Hart, Samuel E. Lynch, Conan Young, Joshua Nickols
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Patent number: 10258566Abstract: The present invention relates to compositions, methods and kits for the treatment of bone particularly impaired or damaged bone.Type: GrantFiled: June 18, 2010Date of Patent: April 16, 2019Assignee: BIOMIMETIC THERAPEUTICS, LLCInventors: Charles E. Hart, Jeffrey O. Hollinger, Samuel E. Lynch
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Patent number: 9642892Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).Type: GrantFiled: June 21, 2013Date of Patent: May 9, 2017Assignee: BioMimetic Therapeutics, LLCInventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
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Patent number: 9642891Abstract: The present invention provides compositions and methods for attaching tendon to bone. The present invention provides compositions and methods for treating rotator cuff injuries. In one embodiment, a method for treating rotator cuff injuries comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to at least one site of tendon reattachment on the humeral head.Type: GrantFiled: July 2, 2007Date of Patent: May 9, 2017Assignee: BioMimetic Therapeutics, LLCInventors: Charles E. Hart, Samuel E. Lynch, Conan Young, Joshua Nickols
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Patent number: 9545377Abstract: A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.Type: GrantFiled: July 16, 2007Date of Patent: January 17, 2017Assignee: BioMimetic Therapeutics, LLCInventor: Samuel E. Lynch
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Publication number: 20150355191Abstract: The present disclosure relates to a method for detecting the presence of PDGF neutralizing antibodies in a serum sample, comprising contacting a population of cells with i) a serum sample, and ii) PDGF, wherein the cells comprise a PDGF receptor; and detecting an amount of a biomarker in the population of cells, wherein the biomarker indicates binding of the PDGF with the PDGF receptor. The present disclosure also relates to a method of determining the presence of PDGF neutralizing antibodies in a subject who has received or is currently receiving a treatment comprising PDGF.Type: ApplicationFiled: June 28, 2013Publication date: December 10, 2015Applicant: BioMimetic Therapeutics, LLCInventors: Leo B. Snel, Luis Solchaga
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Patent number: 9161967Abstract: The present invention relates to compositions and methods useful for treating structures of the vertebral column, including vertebral bodies. In one embodiment, a method for promoting bone formation in a vertebral body comprising providing a composition comprising a PDGF solution and a biocompatible matrix and applying the composition to at least one vertebral body. Promoting bone formation in a vertebral body, according to some embodiments, can increase bone volume, mass, and/or density leading to an increase in mechanical strength of the vertebral body treated with a composition of the present invention.Type: GrantFiled: December 4, 2009Date of Patent: October 20, 2015Assignee: BioMimetic Therapeutics, LLCInventors: Charles E. Hart, Samuel E. Lynch, Conan S. Young, Dan Perrien
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Patent number: 8870954Abstract: The invention provides compositions and methods for treatment of tendon and ligament injuries and/or repair of damaged tendons and ligament. The invention provides compositions comprising a biocompatible matrix and platelet-derived growth factor (PDGF).Type: GrantFiled: September 9, 2009Date of Patent: October 28, 2014Assignee: BioMimetic Therapeutics, LLCInventors: Samuel E. Lynch, Leslie A. Wisner-Lynch, Hans K. Kestler, Yanchun Liu
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Publication number: 20140308332Abstract: The present invention provides compositions and methods for promoting fusion of bones in spine fusion procedures. In some embodiments, a method of performing a spine fusion procedure comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to a site of desired spine fusion.Type: ApplicationFiled: December 13, 2011Publication date: October 16, 2014Applicant: BIOMIMETIC THERAPEUTICS, LLCInventors: Samuel E. Lynch, Leo B. Snel, Christopher K. Hee
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Publication number: 20140005110Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).Type: ApplicationFiled: June 21, 2013Publication date: January 2, 2014Applicant: BioMimetic Therapeutics, LLCInventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
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Patent number: 8492335Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).Type: GrantFiled: February 22, 2011Date of Patent: July 23, 2013Assignee: BioMimetic Therapeutics, LLCInventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar