Abstract: This invention provides a method of preparing large liposomes with high entrapment capacity for pharmaceutical substances. The method generally entails infusing a lipid/alcohol solution directly into an aqueous polymer solution. The resulting liposome, which may be incorporated with a pharmaceutical substance, typically consists of multilamellar vesicles that have an average size of about 1 to about 8 microns. The ratio of lipid to polymer, average molecular weight of the polymer, polymer concentration, ionic strength, and temperature of incubation are variables disclosed herein to control liposome size and incorporation of components and pharmaceutical substances.
Type:
Application
Filed:
December 3, 2001
Publication date:
October 31, 2002
Applicant:
BIOMIRA U.S.A., Inc.
Inventors:
Lawrence Boni, Fangjun Wu, Roy Fennimore, Michael M. Batenjany
Abstract: Membrane-proteoliposome structures (MPs) are useful in preparing patient-specific vaccines against specific white blood cell (WBC) malignancies. The inventive MPs typically contain a membrane component derived from a specific WBC. Other useful components include immunostimulators and exogenous lipids. The resulting vaccines are both patient- and malignancy-specific.
Type:
Application
Filed:
April 12, 2002
Publication date:
October 24, 2002
Applicant:
BIOMIRA U.S.A., Inc.
Inventors:
Mircea C. Popescu, Lawrence Boni, Richard J. Robb, Michael M. Batenjany
Abstract: Membrane-proteoliposome structures (MPs) are useful in preparing patient-specific vaccines against specific white blood cell (WBC) malignancies. The inventive MPs typically contain a membrane component derived from a specific WBC. Other useful components include immunostimulators and exogenous lipids. The resulting vaccines are both patient- and malignancy-specific.
Type:
Grant
Filed:
January 15, 1999
Date of Patent:
March 27, 2001
Assignee:
Biomira U.S.A., Inc.
Inventors:
Mircea C. Popescu, Lawrence Boni, Richard J. Robb, Michael M. Batenjany