Patents Assigned to Biomol International LP
  • Compositions for manipulating the lifespan and stress response of cells and organisms
    Patent number: 7544497
    Abstract: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
    Type: Grant
    Filed: July 1, 2004
    Date of Patent: June 9, 2009
    Assignees: President and Fellows of Harvard College, Biomol International LP
    Inventors: David A. Sinclair, Konrad T. Howitz, Robert E. Zipkin, Kevin J. Bitterman, Dudley W. Lamming