Abstract: The present invention relates to a mutant polypeptide linker for preparing multispecific antibodies, multispecific antibodies, and methods for producing multispecific antibodies.
Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having a particular set of mutations at the interface of the CH1 and CL domains, the mutations preventing heavy chain/light chain mispairing.
Type:
Grant
Filed:
March 27, 2018
Date of Patent:
January 24, 2023
Assignee:
BIOMUNEX PHARMACEUTICALS
Inventors:
Eugene Zhukovsky, Olivier Leger, Richard J. Morse
Abstract: The present invention relates to a bispecific molecule comprising at least one anti-CD38 domain and at leak one anti-PD-L1 domain, which are capable of simultaneous binding to CD38 and PD-L1 antigens, respectively.
Type:
Grant
Filed:
March 27, 2017
Date of Patent:
November 22, 2022
Assignee:
BIOMUNEX PHARMACEUTICALS
Inventors:
Eugene Zhukovsky, Olivier Leger, Richard J. Morse