Patents Assigned to BIONANOMATRIX, INC.
  • POLYNUCLEOTIDE MAPPING AND SEQUENCING
    Publication number: 20110306504
    Abstract: The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
    Type: Application
    Filed: November 18, 2009
    Publication date: December 15, 2011
    Applicant: Bionanomatrix, Inc.
    Inventors: Ming Xiao, Han Cao, Parikshit A. Deshpande, Michael Boyce-Jacino
  • INTEGRATED ANALYSIS DEVICES AND RELATED FABRICATION METHODS AND ANALYSIS TECHNIQUES
    Publication number: 20110296903
    Abstract: Provided are integrated analysis devices having features of macroscale and nanoscale dimensions, and devices that have reduced background signals and that reduce quenching of fluorophores disposed within the devices. Related methods of manufacturing these devices and of using these devices are also provided.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 8, 2011
    Applicant: Bionanomatrix, Inc.
    Inventors: Han Cao, Michael D. Austin, Parikshit A. Deshpande, Mark Kunkel, Alexey Y. Sharonov, Michael Kochersperger
  • METHODS AND DEVICES FOR SINGLE-MOLECULE WHOLE GENOME ANALYSIS
    Publication number: 20110171634
    Abstract: Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.
    Type: Application
    Filed: June 30, 2009
    Publication date: July 14, 2011
    Applicant: Bionanomatrix, Inc.
    Inventors: Ming Xiao, Parikshit A. Deshpande, Han Cao, Michael Austin, Kandaswamy Vijayan, Alexey Y. Sharonov, Michael Boyce-Jacino
  • NANONOZZLE DEVICE ARRAYS: THEIR PREPARATION AND USE FOR MACROMOLECULAR ANALYSIS
    Publication number: 20090305273
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macro-molecules using such devices.
    Type: Application
    Filed: July 19, 2007
    Publication date: December 10, 2009
    Applicant: BIONANOMATRIX, INC.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael D. Austin, Michael Boyce-Jacino