Abstract: The present invention provides a newly isolated mutant culture of Actinoplanes teichomyceticus BNG 2315. This culture is capable of producing teicoplanin more than 60 times productivity than those reported before (e.g., Actinoplanes teichomyceticus nov. sp. ATCC 31121). The present invention also provides a fermentation process for the production of teicoplanin in an aerobic condition using the mutant strain Actinoplanes teichomyceticus BNG 2315 in a culture-medium comprising carbon sources, nitrogen sources and mineral salts.
Abstract: The present Invention is to provide a novel strain, Candida magnoliae (KCCM-10252) producing mannitol isolated from the fermentation sludge collected from a xylitol manufacturing company, and further a method for manufacturing mannitol with high yield and high productivity by optimizing various culture conditions and medium composition using the new strain, Candida magnoliae.
Type:
Grant
Filed:
October 18, 2001
Date of Patent:
March 4, 2003
Assignees:
BioNgene Co., Ltd., Bolak Co., Ltd.
Inventors:
Kyung Hwa Song, Hong Baek, Song Mi Park, Hyung Hwan Hyun, Soo Ryun Jung, Sang Yong Kim, Jung Kul Lee, Ji Yoon Song
Abstract: The present invention relates to a fermentation process to have a high productivity with a novel mutant of Pichia sp., more specifically, for preparing erythritol under optimal fermentation conditions for maximum erythritol production by optimizing the environmental conditions of culture such as pH, temperature and by controlling osmotic pressure. A two-stage fermentation was performed to control osmotic pressure. Osmotic pressure was adjusted to a low level during growth phase and to a relatively high level during production phase by adding continuously glucose and NaCl or KCl. Therefore, erythritol production could be increased.
Type:
Grant
Filed:
August 26, 1999
Date of Patent:
November 13, 2001
Assignee:
BioNgene Co., Ltd.
Inventors:
Sang Yong Kim, Deok Kun Oh, Soo Ryun Jung
Abstract: The present invention relates to a fermentation process to have a high productivity with a novel mutant of Torula sp. DS101 (KCMM-10171), more specifically, for preparing erythritol using mother liquor produced from purification process, which comprises 30˜60% of trehalulose, 10˜30% of palatinose, 5˜15% of fructose, 5˜25% of glucose and 0˜10% of sucrose.
Type:
Grant
Filed:
December 21, 1999
Date of Patent:
August 7, 2001
Assignees:
Bolak Co., Ltd., BioNgene Co., Ltd.
Inventors:
Sang Yong Kim, Deok Kun Oh, Bong Soo Noh, Soo Ryun Jung, Kyung Ah Kim