Patents Assigned to BIONOMICS INC.
  • Methods of blocking cancer stem cell growth
    Patent number: 10598653
    Abstract: Disclosed herein are antibodies against GPR49 and uses of such antibodies. The antibodies can be monoclonal, humanized, or fully human antibodies against GPR49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies, and methods of blocking cancer stem cell growth with such antibodies.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: March 24, 2020
    Assignee: BIONOMICS INC.
    Inventors: Christopher L. Reyes, Peter Chu, Xiangyang Tan, Weixing Yang, Christilyn Graff
  • Humanized antibodies that bind LGR5
    Patent number: 10358500
    Abstract: Disclosed herein are humanized anti-LGR5 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR5 without disrupting LGR5-RSPO1 binding or signaling, and may disrupt LGR5 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for the biding of LGR5, for example without disrupting LGR5-RSPO binding or signaling.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: July 23, 2019
    Assignee: BIONOMICS INC.
    Inventors: Christopher L. Reyes, Peter Chu, Kristen M. Smith, Lioudmila A. Campbell, Farbod Shojaei, John Thomas Norton
  • Methods of inhibiting growth of a colon cancer tumor in a subject by administering monoclonal antibodies to G protein-coupled receptor 49 (GPR49)
    Patent number: 10196442
    Abstract: Described herein are antibodies against GPR49 and uses of such antibodies. Various aspects relate to monoclonal, humanized, or fully human antibodies against GPR49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies, and methods of treating cancer with such antibodies.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: February 5, 2019
    Assignee: Bionomics Inc.
    Inventors: Christopher L. Reyes, Peter Chu, Xiangyang Tan, Christilyn Graff, Weixing Yang
  • Antibodies that bind LGR4, their use in inhibiting neoplastic cells and in treating tumors
    Patent number: 9631024
    Abstract: Disclosed herein are anti-LGR4 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR4 without disrupting LGR4-RSPO1 binding or signaling, and may disrupt LGR4 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for antibodies that bind LGR4, for example without disrupting LGR4-RSPO binding or signaling.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: April 25, 2017
    Assignee: Bionomics, Inc.
    Inventors: Christopher L. Reyes, Kristen M. Smith, Peter Chu, Lioudmila A. Campbell, Eric Ailor
  • Humanized antibodies that bind LGR5
    Patent number: 9546214
    Abstract: Disclosed herein are humanized anti-LGR5 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR5 without disrupting LGR5-RSPO1 binding or signaling, and may disrupt LGR5 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for the biding of LGR5, for example without disrupting LGR5-RSPO binding or signaling.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: January 17, 2017
    Assignee: Bionomics, Inc.
    Inventors: Christopher L. Reyes, Peter Chu, Kristen M. Smith, Lioudmila A. Campbell, Farbod Shojaei, John Thomas Norton
  • Methods of inhibiting solid tumor growth by administering GPR49 antibodies
    Patent number: 9221906
    Abstract: Described herein are antibodies against GPR49 and uses of such antibodies. Various aspects relate to monoclonal, humanized, or fully human antibodies against GPR49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies, and methods of treating cancer with such antibodies.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: December 29, 2015
    Assignee: Bionomics Inc.
    Inventors: Christopher L. Reyes, Peter Chu, Xiangyang Tan, Christilyn Graff, Weixing Yang
  • Anti-GPR49 monoclonal antibodies
    Patent number: 9221907
    Abstract: Described herein are to antibodies against GPR49 and uses of such antibodies. Various aspects relate to monoclonal, humanized, or fully human antibodies against GPR49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: December 29, 2015
    Assignee: Bionomics Inc.
    Inventors: Christopher L. Reyes, Peter Chu, Xiangyang Tan, Weixing Yang, Christilyn Graff
  • Methods of treating cancer by administering anti-GPR49 antibodies
    Patent number: 9220774
    Abstract: Described herein are antibodies against GPR49 and uses of such antibodies. Various aspects relate to monoclonal, humanized, or fully human antibodies against GPR49, hybridomas or other cell lines expressing such antibodies, nucleic acids and vectors comprising nucleic acids encoding for such antibodies.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: December 29, 2015
    Assignee: Bionomics Inc.
    Inventors: Christopher L. Reyes, Peter Chu, Xiangyang Tan, Weixing Yang, Christilyn Graff
  • CANCER STEM CELLS EXPRESSING ABCG2
    Publication number: 20130244268
    Abstract: Cancer Stem Cell populations characterized by expression of ABCG2 and methods of isolating and using the same are disclosed.
    Type: Application
    Filed: March 1, 2013
    Publication date: September 19, 2013
    Applicant: BIONOMICS INC.
    Inventors: Peter Chu, Robert Peach