Patents Assigned to Bionorica AG
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Publication number: 20140147502Abstract: The present invention relates to an antibacterial agent and a hydrolysate made of at least one extract that has been produced by extraction using ethanol/water from dried plant material of: a) at least one of the plants selected from the group consisting of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Primula elatior (L.) Hill, and Gentiana lutea L.; and a mixture thereof; or b) a mixture of: Verbena officinalis L., Sambucus nigra L., Primula veris L., Gentiana lutea L., and Rumicis herba; and subsequent removal of the ethanol/water extraction agent, wherein the hydrolysate can be obtained from the extract via hydrolytic treatment using a mineral acid. The hydrolyzates according to the invention show a pronounced antibacterial effect against germs relevant to the skin, ears, nose, and throat and respiratory systems.Type: ApplicationFiled: January 31, 2014Publication date: May 29, 2014Applicant: Bionorica AGInventors: Guenther Bonn, Guenther Stecher, Michael A. Popp, Robert Mayer
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Publication number: 20130183394Abstract: The invention relates to a cosmetic or dermatological composition, preferably purely plant-based, for topical use, containing Cimicifuga as the primary natural active ingredient, and to the use thereof for the prophylaxis and the treatment of skin diseases, in particular acne, seborrhea, atopic eczema (neurodermatitis), hirsutism, psoriasis, and dry/atopic skin of humans.Type: ApplicationFiled: September 19, 2008Publication date: July 18, 2013Applicant: BIONORICA AGInventor: Wolfgang Wuttke
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Publication number: 20100210860Abstract: The present invention relates to a method for the preparation of dronabinol ((6aR-trans)-6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo[b,d]pyran-1-ol, ?9-tetrahydrocannabinol (?9-THC)) from cannabidiol (CBD) by cyclization of cannabidiol (CBD) (2-[1R-3-methyl-6-(1-methylethenyl)-2-cyclohexene-1-yl]-5-pentyl-1,3-benzoldiol) to ?9-THC. The method according to the present invention is characterized in that cannabidiol (CBD) (B) is present in an organic solvent and cyclized to ?9-THC in the presence of a molecular sieve while being heated. It was found out that, in the method of the present invention, the molecular sieve not only has the previously mentioned drying properties, but also exhibits strong catalytic properties which are important in this reaction. Normally, cyclizations carried out in the presence of a Lewis acid catalyst only are distinctly slower and the ?9-THC yield is lower than in cyclizations carried out in the present of a molecular sieve.Type: ApplicationFiled: June 1, 2006Publication date: August 19, 2010Applicant: Bionorica AGInventors: Joachim Erler, Stefan Heitner
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Patent number: 7715002Abstract: A method is provided for characterizing a scientific material, such as a silicate material, a polymer material and/or nanomaterial. The method can include the steps of irradiating a measuring light of a predetermined wavelength range into material specimens, recording the measuring light reflected and/or reemitted by the material specimens, determining a ratio depending on the wave lengths of irradiated to detected measuring light (spectrum), and numerical-mathematical processing of spectral data of single material specimens for determining the characteristic features of the material specimens.Type: GrantFiled: January 23, 2007Date of Patent: May 11, 2010Assignee: Bionorica AGInventors: Michael A. Popp, Guenther Bonn, Christian W. Huck
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Publication number: 20100068273Abstract: A pharmaceutical formulation of a calcium salt and a dry plant extract in the form of a coated tablet, in which the formulation has a core of at least one dry plant extract, enveloped by at least one coating of at least one calcium salt. The plant extracts for the core may be selected from: Vitex agnus castus (chaste tree); Belamcanda chinensis (leopard lily); Cimicifuga racemosa (black cohosh); Trifolium pratense L. (purple trefoil); Oenothera biennis hom. (primrose); Glycine soja (soy bean); Serenoa repens (saw-palmetto); Urtica dioica (stinging nettle), in particular its root; Cucurbita pepo (pumpkin), in particular its seed; Pygeum africanum; as well as suitable mixtures of these. Methods for the use of the formulation in treating osteoporosis and for manufacturing the formulation are provided.Type: ApplicationFiled: November 12, 2009Publication date: March 18, 2010Applicant: BIONORICA AGInventor: Michael A. Popp
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Patent number: 7629005Abstract: A pharmaceutical formulation of a calcium salt and a dry plant extract in the form of a coated tablet, in which the formulation has a core of at least one dry plant extract, enveloped by at least one coating of at least one calcium salt. The plant extracts for the core may be selected from: Vitex agnus castus (chaste tree); Belamcanda chinensis (leopard lily); Cimicifuga racemosa (black cohosh); Trifolium pratense L. (purple trefoil); Oenothera biennis hom. (primrose); Glycine soja (soy bean); Serenoa repens (saw-palmetto); Urtica dioica (stinging nettle), in particular its root; Cucurbita pepo (pumpkin), in particular its seed; Pygeum africanum; as well as suitable mixtures of these. Methods for the use of the formulation in treating osteoporosis and for manufacturing the formulation are provided.Type: GrantFiled: April 10, 2002Date of Patent: December 8, 2009Assignee: Bionorica AGInventor: Michael A. Popp
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Patent number: 7413754Abstract: The present invention relates to extracts from Cimicifuga species and particularly from Cimicifuga racemosa, which are suited for producing a ready-formulated drug for the selective treatment and/or prophylaxis of sexual hormone-related disorders of the uro-genital tract. The extracts in accordance with the invention are moreover suited for the treatment and/or prophylaxis of post-menopausal urinary bladder infections. They are furthermore indicated for the treatment of benign and malignant prostate hyperplasies.Type: GrantFiled: September 16, 2002Date of Patent: August 19, 2008Assignee: Bionorica AGInventors: Wolfgang Wuttke, Hubertus Jarry, Volker Christoffel, Barbara Spengler
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Publication number: 20080177481Abstract: A method is provided for characterizing a scientific material, such as a silicate material, a polymer material and/or nanomaterial. The method can include the steps of irradiating a measuring light of a predetermined wavelength range into material specimens, recording the measuring light reflected and/or reemitted by the material specimens, determining a ratio depending on the wave lengths of irradiated to detected measuring light (spectrum), and numerical-mathematical processing of spectral data of single material specimens for determining the characteristic features of the material specimens.Type: ApplicationFiled: January 23, 2007Publication date: July 24, 2008Applicant: BIONORICA AGInventors: Michael A. Popp, Guenther Bonn, Christian W. Huck
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Patent number: 7291250Abstract: The present invention relates to a vacuum distillation plant and a process for concentrating organic aqueous solutions, especially spissum extracts, using said plant. The vacuum distillation plant of the invention comprises a flash evaporator, a means for vapor concentration and a multi-stage condenser positioned down-stream of said means for vapor concentration, means for recycling at least part of the condensate from a condensation stage into the bottoms product being provided. In addition, the present invention relates to a process for concentrating organic aqueous solutions such as concentrated extracts using said plant.Type: GrantFiled: October 20, 1999Date of Patent: November 6, 2007Assignee: Bionorica AGInventors: Michael A. Popp, Heinz Walter Joseph, Michael R. Rannow
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Patent number: 7244902Abstract: A method for classifying beverages of natural origin, such as wine or coffee. Classification is carried out by means of NIR spectroscopy and corresponding numerical-mathematical conditioning of the spectral data of the individual beverage samples, wherein respective obtained spectra are then correlated with a predetermined beverage, class. By means of the method of the invention it is possible to classify wines by sort of wine, growing regions, grape, vine, vintage, kind of material or wood of the wine cask used, and varying degree of maturity of the wine, and by other chemical parameters. Coffee, for example, may be classified by coffee sort, country of origin, coffee growing region, roasting method and defined chemical parameters, e.g., caffeine content, or chlorogenic acid content.Type: GrantFiled: May 6, 2002Date of Patent: July 17, 2007Assignee: Bionorica AGInventors: Michael A. Popp, Günther Bonn, Christian Huck, Wolfgang Guggenbichler
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Patent number: 6996919Abstract: The invention concerns a method for obtaining dry plant extracts under mild conditions, in which a liquid plant extract is introduced into a vacuum drying equipment having a multi-shaft stirrer extending through a cylindrical mixing and drying chamber and with its own drive, together with a chopper rotating through a stator, and the liquid plant extract is dried at a vessel shell temperature of 20° C. to 50° C., a product temperature between 20° C. and 40° C., a pressure between 0.Type: GrantFiled: March 12, 2002Date of Patent: February 14, 2006Assignee: Bionorica AGInventor: Heinz-Walter Joseph
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Patent number: 6635672Abstract: The present invention relates to a prolactin lowering drug containing at least one bicyclic diterpene of the labdane or clerodane type: wherein R1=H, C1 to C3 alkyl or C1 to C3 acyl.Type: GrantFiled: September 24, 2001Date of Patent: October 21, 2003Assignee: Bionorica AGInventors: Wolfgang Wuttke, Hubertus Jarry, Michael Popp, Volker Christoffel, Barbara Spengler