Patents Assigned to BioNovo, Inc.
  • Patent number: 9446086
    Abstract: A novel herbal extract, MF101, is effective in the treatment of symptoms of menopause.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: September 20, 2016
    Assignee: BIONOVO, INC.
    Inventor: Isaac Cohen
  • Patent number: 9339523
    Abstract: Estrogenic extracts of Asparagus conchinchinensis (Lour.) Merr of the Liliaceae Family are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: May 17, 2016
    Assignee: BIONOVO, INC.
    Inventor: Isaac Cohen
  • Patent number: 9220740
    Abstract: Estrogenic extracts of Astragalus membranaceus Fisch. Bge. Var. mongolicus Bge. of the Leguminosae Family are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: December 29, 2015
    Assignee: BIONOVO, INC.
    Inventor: Isaac Cohen
  • Patent number: 9155770
    Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Scutellaria barbata D. Don of the Labiatae Family species possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: October 13, 2015
    Assignee: BIONOVO, INC.
    Inventor: Isaac Cohen
  • Patent number: 9132161
    Abstract: Extracts of various species of the Polygonaceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Rheum palmatum L of the Polygonaceae family species possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: September 15, 2015
    Assignee: BIONOVO, INC.
    Inventor: Isaac Cohen
  • Patent number: 8512961
    Abstract: An extract of Scutellaria Barbata D. Don is effective in the arrest of cancer cell growth. The extract of Scutellaria Barbata D. Don may be used as a therapeutic treatment for patients who have been identified as having cancer. In some situations, a patient is identified as having a type of cancer by detecting the presence of a biomarker for that cancer in the patient's system and by further determining the level of that biomarker in the patient's system. If the level of the biomarker is above a predetermined threshold level for that biomarker, the patient may be diagnosed with cancer. Subsquently, treatment using an extract of Scutellaria Barbata D. Don may begin. Biomarkers of interest in the detection of the presence of metastitic breast cancer include 8-oxoguanine and lactate dehydrogenase.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: August 20, 2013
    Assignee: Bionovo, Inc.
    Inventor: Isaac Cohen
  • Publication number: 20120277169
    Abstract: Estrogenic compositions comprising nyasol and analogs thereof are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.
    Type: Application
    Filed: November 1, 2011
    Publication date: November 1, 2012
    Applicant: BioNovo, Inc.
    Inventor: Isaac Cohen
  • Patent number: 8197868
    Abstract: An extract of Scutellaria barbata D. Don is effective in the arrest of cancer cell growth in the G1 phase, the induction of apoptosis in cancer cells and the shrinking of solid cancers. The extract may be prepared as a pharmaceutical composition for administration to mammals for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers. The extract is obtained from Scutellaria barbata D. Don by contacting aerial portions of a plant from the species Scutellaria barbata D. Don with an aqueous or alcoholic solvent.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: June 12, 2012
    Assignee: BioNovo, Inc.
    Inventor: Isaac Cohen
  • Publication number: 20120114773
    Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Ligustrum lucidum Ait. of the Oleaceae Family possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.
    Type: Application
    Filed: December 12, 2011
    Publication date: May 10, 2012
    Applicant: BioNovo, Inc.
    Inventor: Isaac Cohen
  • Publication number: 20120107344
    Abstract: A novel herbal extract, MF101, is effective in the treatment of symptoms of menopause.
    Type: Application
    Filed: November 28, 2011
    Publication date: May 3, 2012
    Applicant: BioNovo, Inc.
    Inventor: Isaac Cohen
  • Publication number: 20120045532
    Abstract: Selective apoptotic extracts of Gleditsia sinensis Lam are provided. Also provided are methods of using said extracts to induce apoptosis in specific cells, especially in a human. Provided as well are uses of the extracts of Gleditsia sinensis Lam for the preparation of a medicament for the selective induction of apoptosis.
    Type: Application
    Filed: November 1, 2011
    Publication date: February 23, 2012
    Applicant: BioNovo, Inc.
    Inventor: Isaac Cohen
  • Patent number: 8110228
    Abstract: A method of using an herbal extract of the a mixture of: Herba Scutellaria barbata, Radix Sophora subprostratae, Radix Anemarrhena, Semen Glycine sojae, Radix Glycyrrhiza, Rhizoma Rhei, Fructus Tritici levis, Radix Astragali, Radix Rehmania, Fructus Ligustri lucidi, Semen Zyziphi spinosa, Plumula Nelumbinis, Poria cocas, Rhizoma Alismatis, Cortex Moutan radicis, Fructus Corni, Radix Achyranthis, Concha Ostrea, Radix Aspargi, Radix Pueraria, Radix Atractylodis macrocephala and Herba Epimedium, for the treatment of hot flashes associated with menopause is disclosed herein.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: February 7, 2012
    Assignee: Bionovo, Inc.
    Inventor: Isaac Cohen
  • Patent number: 8092841
    Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Ligustrum lucidum Ait. of the Oleaceae Family possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: January 10, 2012
    Assignee: Bionovo, Inc.
    Inventor: Isaac Cohen
  • Publication number: 20100330213
    Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Morus alba L. species possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effect include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.
    Type: Application
    Filed: September 2, 2010
    Publication date: December 30, 2010
    Applicant: BIONOVO, INC.
    Inventor: Isaac Cohen
  • Patent number: 7815949
    Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Morus alba L. species possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effect include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: October 19, 2010
    Assignee: BioNovo, Inc.
    Inventor: Isaac Cohen
  • Publication number: 20100234310
    Abstract: Isolated compounds and combinations of isolated compounds isolated from Epimedium grandiflorum Morr. are estrogenic, and can be used to treat one or more symptoms of menopause and/or ER-positive cancer. The compounds and combinations may be prepared as pharmaceutical compositions for administration to mammals, such as humans, for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer, uterine cancer, cervical cancer, ovarian cancer, vulvar cancer, endometrial cancer.
    Type: Application
    Filed: February 25, 2010
    Publication date: September 16, 2010
    Applicant: Bionovo, Inc.
    Inventor: Isaac Cohen
  • Publication number: 20100173026
    Abstract: Estrogenic extracts of Astragalus membranaceus Fisch. Bge. Var. mongolicus Bge. of the Leguminosae Family are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.
    Type: Application
    Filed: January 13, 2010
    Publication date: July 8, 2010
    Applicant: Bionovo, Inc.
    Inventor: Isaac Cohen
  • Publication number: 20100143511
    Abstract: An extract of Scutellaria barbata D. Don is effective in the arrest of cancer cell growth in the G1 phase, the induction of apoptosis in cancer cells and the shrinking of solid cancers. The extract may be prepared as a pharmaceutical composition for administration to mammals for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers. The extract is obtained from Scutellaria barbata D. Don by contacting aerial portions of a plant from the species Scutellaria barbata D. Don with an aqueous or alcoholic solvent.
    Type: Application
    Filed: January 21, 2010
    Publication date: June 10, 2010
    Applicant: Bionovo, Inc.
    Inventor: Isaac Cohen
  • Patent number: 7700136
    Abstract: An extract of Scutellaria barbata D. Don is effective in the arrest of cancer cell growth in the G1 phase, the induction of apoptosis in cancer cells and the shrinking of solid cancers. The extract may be prepared as a pharmaceutical composition for administration to mammals for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers. The extract is obtained from Scutellaria barbata D. Don by contacting aerial portions of a plant from the species Scutellaria barbata D. Don with an aqueous or alcoholic solvent.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: April 20, 2010
    Assignee: BioNovo, Inc.
    Inventor: Isaac Cohen
  • Publication number: 20100069480
    Abstract: Isolated compounds and combinations of isolated compounds isolated from Scutellaria barbata D. Don are effective in the generation of reactive oxygen species, induction of DNA damage and induction of apoptosis in cancer cells. The compounds and combinations may be prepared as pharmaceutical compositions for administration to mammals, such as humans, for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers.
    Type: Application
    Filed: September 3, 2009
    Publication date: March 18, 2010
    Applicant: Bionovo, Inc. A Delaware Corporation
    Inventor: Isaac Cohen