Patents Assigned to BioNovo, Inc.
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Patent number: 9446086Abstract: A novel herbal extract, MF101, is effective in the treatment of symptoms of menopause.Type: GrantFiled: November 28, 2011Date of Patent: September 20, 2016Assignee: BIONOVO, INC.Inventor: Isaac Cohen
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Patent number: 9339523Abstract: Estrogenic extracts of Asparagus conchinchinensis (Lour.) Merr of the Liliaceae Family are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.Type: GrantFiled: September 5, 2008Date of Patent: May 17, 2016Assignee: BIONOVO, INC.Inventor: Isaac Cohen
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Patent number: 9220740Abstract: Estrogenic extracts of Astragalus membranaceus Fisch. Bge. Var. mongolicus Bge. of the Leguminosae Family are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.Type: GrantFiled: January 13, 2010Date of Patent: December 29, 2015Assignee: BIONOVO, INC.Inventor: Isaac Cohen
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Patent number: 9155770Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Scutellaria barbata D. Don of the Labiatae Family species possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.Type: GrantFiled: September 5, 2008Date of Patent: October 13, 2015Assignee: BIONOVO, INC.Inventor: Isaac Cohen
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Patent number: 9132161Abstract: Extracts of various species of the Polygonaceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Rheum palmatum L of the Polygonaceae family species possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.Type: GrantFiled: September 5, 2008Date of Patent: September 15, 2015Assignee: BIONOVO, INC.Inventor: Isaac Cohen
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Patent number: 8512961Abstract: An extract of Scutellaria Barbata D. Don is effective in the arrest of cancer cell growth. The extract of Scutellaria Barbata D. Don may be used as a therapeutic treatment for patients who have been identified as having cancer. In some situations, a patient is identified as having a type of cancer by detecting the presence of a biomarker for that cancer in the patient's system and by further determining the level of that biomarker in the patient's system. If the level of the biomarker is above a predetermined threshold level for that biomarker, the patient may be diagnosed with cancer. Subsquently, treatment using an extract of Scutellaria Barbata D. Don may begin. Biomarkers of interest in the detection of the presence of metastitic breast cancer include 8-oxoguanine and lactate dehydrogenase.Type: GrantFiled: November 19, 2008Date of Patent: August 20, 2013Assignee: Bionovo, Inc.Inventor: Isaac Cohen
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Publication number: 20120277169Abstract: Estrogenic compositions comprising nyasol and analogs thereof are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.Type: ApplicationFiled: November 1, 2011Publication date: November 1, 2012Applicant: BioNovo, Inc.Inventor: Isaac Cohen
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Patent number: 8197868Abstract: An extract of Scutellaria barbata D. Don is effective in the arrest of cancer cell growth in the G1 phase, the induction of apoptosis in cancer cells and the shrinking of solid cancers. The extract may be prepared as a pharmaceutical composition for administration to mammals for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers. The extract is obtained from Scutellaria barbata D. Don by contacting aerial portions of a plant from the species Scutellaria barbata D. Don with an aqueous or alcoholic solvent.Type: GrantFiled: November 19, 2008Date of Patent: June 12, 2012Assignee: BioNovo, Inc.Inventor: Isaac Cohen
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Publication number: 20120114773Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Ligustrum lucidum Ait. of the Oleaceae Family possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.Type: ApplicationFiled: December 12, 2011Publication date: May 10, 2012Applicant: BioNovo, Inc.Inventor: Isaac Cohen
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Publication number: 20120107344Abstract: A novel herbal extract, MF101, is effective in the treatment of symptoms of menopause.Type: ApplicationFiled: November 28, 2011Publication date: May 3, 2012Applicant: BioNovo, Inc.Inventor: Isaac Cohen
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Publication number: 20120045532Abstract: Selective apoptotic extracts of Gleditsia sinensis Lam are provided. Also provided are methods of using said extracts to induce apoptosis in specific cells, especially in a human. Provided as well are uses of the extracts of Gleditsia sinensis Lam for the preparation of a medicament for the selective induction of apoptosis.Type: ApplicationFiled: November 1, 2011Publication date: February 23, 2012Applicant: BioNovo, Inc.Inventor: Isaac Cohen
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Patent number: 8110228Abstract: A method of using an herbal extract of the a mixture of: Herba Scutellaria barbata, Radix Sophora subprostratae, Radix Anemarrhena, Semen Glycine sojae, Radix Glycyrrhiza, Rhizoma Rhei, Fructus Tritici levis, Radix Astragali, Radix Rehmania, Fructus Ligustri lucidi, Semen Zyziphi spinosa, Plumula Nelumbinis, Poria cocas, Rhizoma Alismatis, Cortex Moutan radicis, Fructus Corni, Radix Achyranthis, Concha Ostrea, Radix Aspargi, Radix Pueraria, Radix Atractylodis macrocephala and Herba Epimedium, for the treatment of hot flashes associated with menopause is disclosed herein.Type: GrantFiled: October 28, 2008Date of Patent: February 7, 2012Assignee: Bionovo, Inc.Inventor: Isaac Cohen
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Patent number: 8092841Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Ligustrum lucidum Ait. of the Oleaceae Family possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.Type: GrantFiled: August 8, 2008Date of Patent: January 10, 2012Assignee: Bionovo, Inc.Inventor: Isaac Cohen
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Publication number: 20100330213Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Morus alba L. species possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effect include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.Type: ApplicationFiled: September 2, 2010Publication date: December 30, 2010Applicant: BIONOVO, INC.Inventor: Isaac Cohen
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Patent number: 7815949Abstract: Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Morus alba L. species possess estrogenic properties in both ER?+ and ER?+ cells. These estrogenic effect include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.Type: GrantFiled: December 9, 2005Date of Patent: October 19, 2010Assignee: BioNovo, Inc.Inventor: Isaac Cohen
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Publication number: 20100234310Abstract: Isolated compounds and combinations of isolated compounds isolated from Epimedium grandiflorum Morr. are estrogenic, and can be used to treat one or more symptoms of menopause and/or ER-positive cancer. The compounds and combinations may be prepared as pharmaceutical compositions for administration to mammals, such as humans, for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer, uterine cancer, cervical cancer, ovarian cancer, vulvar cancer, endometrial cancer.Type: ApplicationFiled: February 25, 2010Publication date: September 16, 2010Applicant: Bionovo, Inc.Inventor: Isaac Cohen
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Publication number: 20100173026Abstract: Estrogenic extracts of Astragalus membranaceus Fisch. Bge. Var. mongolicus Bge. of the Leguminosae Family are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.Type: ApplicationFiled: January 13, 2010Publication date: July 8, 2010Applicant: Bionovo, Inc.Inventor: Isaac Cohen
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Publication number: 20100143511Abstract: An extract of Scutellaria barbata D. Don is effective in the arrest of cancer cell growth in the G1 phase, the induction of apoptosis in cancer cells and the shrinking of solid cancers. The extract may be prepared as a pharmaceutical composition for administration to mammals for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers. The extract is obtained from Scutellaria barbata D. Don by contacting aerial portions of a plant from the species Scutellaria barbata D. Don with an aqueous or alcoholic solvent.Type: ApplicationFiled: January 21, 2010Publication date: June 10, 2010Applicant: Bionovo, Inc.Inventor: Isaac Cohen
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Patent number: 7700136Abstract: An extract of Scutellaria barbata D. Don is effective in the arrest of cancer cell growth in the G1 phase, the induction of apoptosis in cancer cells and the shrinking of solid cancers. The extract may be prepared as a pharmaceutical composition for administration to mammals for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers. The extract is obtained from Scutellaria barbata D. Don by contacting aerial portions of a plant from the species Scutellaria barbata D. Don with an aqueous or alcoholic solvent.Type: GrantFiled: November 13, 2006Date of Patent: April 20, 2010Assignee: BioNovo, Inc.Inventor: Isaac Cohen
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Publication number: 20100069480Abstract: Isolated compounds and combinations of isolated compounds isolated from Scutellaria barbata D. Don are effective in the generation of reactive oxygen species, induction of DNA damage and induction of apoptosis in cancer cells. The compounds and combinations may be prepared as pharmaceutical compositions for administration to mammals, such as humans, for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers.Type: ApplicationFiled: September 3, 2009Publication date: March 18, 2010Applicant: Bionovo, Inc. A Delaware CorporationInventor: Isaac Cohen