Abstract: Systems, compositions, and methods for isolating HLA-peptides from cells. A universal platform and methods for profiling the HLA-peptidome, enabling identification of endogenously presented HLA-peptides from cell lines expressing any possible class I or II construct.
Type:
Grant
Filed:
February 12, 2018
Date of Patent:
April 23, 2024
Assignee:
BioNTech US Inc.
Inventors:
Jennifer Grace Abelin, Rob Carl Oslund, Nir Hacohen, Dominik Barthelme, Michael Rooney
Abstract: Disclosed herein relates to immunotherapeutic compositions comprising immunotherapeutic peptides comprising neoepitopes, polynucleotides encoding the immunotherapeutic peptides, antigen presenting cells comprising the immunotherapeutic peptides or polynucleotides, or T cell receptors specific for the neoepitopes. Also disclosed herein is use of the immunotherapeutic compositions.
Abstract: Compositions and methods for isolating HLA-peptides from cells. A universal platform and methods for profiling the HLA-peptidome, enabling identification of endogenously presented HLA-peptides from cell lines expressing any possible class I or II construct.
Type:
Grant
Filed:
November 22, 2019
Date of Patent:
May 16, 2023
Assignee:
BioNTech US INC.
Inventors:
Jennifer Grace Abelin, Rob Carl Oslund, Nir Hacohen, Dominik Barthelme, Michael Rooney
Abstract: The generation of antigen specific T cells by controlled ex vivo induction or expansion can provide highly specific and beneficial T cell therapies. The present disclosure provides T cell manufacturing methods and therapeutic T cell compositions which can be used for treating subjects with cancer and other conditions, diseases and disorders personal antigen specific T cell therapy.
Type:
Grant
Filed:
January 6, 2020
Date of Patent:
November 2, 2021
Assignees:
BIONTECH US INC., Stichting Het Nederlands Kanker Instituut—Antoni Van Leeuwenhoek Ziekenhuis
Inventors:
Marit M. Van Buuren, Divya Reddy Lenkala, Joost Huibert Van Den Berg, Jessica Kohler, Matthew Goldstein, Ed Fritsch, Renate De Boer, Ton Schumacher, Noor Bakker