Abstract: A method of treatment using 2-substituted-6-(substituted benzylamino)purine riboside derivatives of the general formula I. These compounds possess antiapoptotic, anti-inflammatory and differentiating activities.
Type:
Application
Filed:
October 7, 2013
Publication date:
March 6, 2014
Applicants:
Biopatterns, S.R.O, Univerzita Palackeho V Olomouci
Inventors:
Lucie SZUCOVA, Vladimir KRYSTOF, Marek ZATLOUKAL, Karel DOLEZAL, Miroslav STRNAD, Lukas SPICHAL
Abstract: The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines.
Type:
Grant
Filed:
June 2, 2010
Date of Patent:
July 23, 2013
Assignees:
Univerzita Palackeho V Olomouci, Biopatterns, S.R.O.
Inventors:
Marek Zatloukal, Vladimir Krystof, Libor Havlicek, Igor Popa, Karel Dolezal, Miroslav Strnad, Radek Jorda