Abstract: The aspects of the disclosed embodiments are directed to novel compounds, specifically, quaternary ammonium derivatives of tertiary amine containing opioid drug compounds such as hydrocodone, hydromorphone and oxycodone, formulations containing said. compounds or pharmaceutically acceptable salts thereof, which are capable of providing controlled release of the opioid drug upon administration to a patient in order to treat pain.
Type:
Grant
Filed:
April 16, 2014
Date of Patent:
September 11, 2018
Assignee:
BIOPHARMA WORKS
Inventors:
Robert Volkmann, Anthony Marfat, Peter Cornelius, Panayiotis Zagouras, Fredrick Raymond Nelson, Anton Franz Joseph Fliri
Abstract: The present invention relates to novel biguanide derivatives including their pharmaceutically acceptable salts. The invention also relates processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions containing and the uses of such compounds in treating disorders such as diabetes.
Abstract: The present invention is directed to Ganaxolone prodrugs with increased aqueous solubility and oral bioavailability relative to Ganaxolone and that enable development of stable extended release formulations which offer a significant therapeutic advantage and improved patience compliance by enabling treatments with lower doses over prolonged periods of time.
Abstract: The invention is directed to novel compounds, formulations containing said compounds or pharmaceutically acceptable salts thereof which are suitable for administration to a patient.
Type:
Grant
Filed:
April 16, 2014
Date of Patent:
November 8, 2016
Assignee:
BioPharma Works LLC
Inventors:
Robert Volkmann, Anthony Marfat, Peter Cornelius, Panayiotis Zagouras, Frederick Raymond Nelson, Anton Franz Joseph Fliri