Patents Assigned to BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
  • Method for the preparation of sulfobutylether beta cyclodextrin sodium
    Patent number: 11274164
    Abstract: The present invention relates to an improved method for the synthesis of sulfobutylether beta cyclodextrin sodium and to provide an amorphous form of sulfobutylether beta cyclodextrin sodium having a 1,4-butane sultone content less than 0.5 ppm. The present invention further provides sulfobutylether beta cyclodextrin sodium containing less than 35 IU/g of Bacterial endotoxins.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: March 15, 2022
    Assignee: BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
    Inventors: Manik Reddy Pullagurla, Bhaskar Reddy Pitta, Suresh Babu Namana, Radha Nagarapu, Jagadeesh Babu Rangisetty
  • Process for the preparation of gadolinium complex of (4S)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanedioic acid disodium (Gadoxetate disodium)
    Patent number: 11149041
    Abstract: The present invention discloses a novel process for the preparation of gadolinium complex of (4S)-4-(4-Ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanedioic acid disodium of formula 1 and novel intermediates thereof.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: October 19, 2021
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Bhaskar Reddy Pitta, Suresh Babu Namani, Jagadeesh Babu Rangisetty
  • Process for the preparation of tavaborole, its novel polymorphic forms and the polymorphs thereof
    Patent number: 11091504
    Abstract: The invention relates to novel process for preparation of Tavaborole. The invention also relates to novel polymorphic forms of Tavaborole and process for preparation of those polymorphic forms. The invention also relates to process for purification of Tavaborole to obtain the Tavaborole in significantly high yield and substantially pure form.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: August 17, 2021
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Mecheril Valsan Nanda Kumar, Bhaskar Reddy Pitta, Jagadeesh Babu Rangisetty
  • Process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (Crisaborole)
    Patent number: 10981939
    Abstract: The present invention relates to a novel process for the preparation of substantially pure Crisaborole (I).
    Type: Grant
    Filed: May 12, 2018
    Date of Patent: April 20, 2021
    Assignee: BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
    Inventors: Manik Reddy Pullagurla, Bhaskar Reddy Pitta, Suresh Babu Namana, Jagadeesh Babu Rangisetty
  • Process for the preparation of Indigotindisulfonate sodium (indigo carmine)
    Patent number: 10927258
    Abstract: This invention relates to an improved method for the preparation of highly or substantially pure Indigotindisulfonate sodium (1). It further relates to the novel crystalline form I of Indigotindisulfonate sodium (1) and the process for its preparation.
    Type: Grant
    Filed: December 23, 2017
    Date of Patent: February 23, 2021
    Assignee: BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty
  • Method for the synthesis of ferric oraganic compounds
    Patent number: 10882813
    Abstract: The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: January 5, 2021
    Assignee: Biophore India Pharmaceuticals Pvt. Ltd.
    Inventors: Manik Reddy Pullagurla, Mecheril Valsan Nanda Kumar, Jagadeesh Babu Rangisetty, Rajesh Bhudeti, Radha Nagarapu
  • Isosulfan blue, its crystalline form and process for preparation thereof
    Patent number: 10723745
    Abstract: Provided is an improved process for the preparation N-[4-[[4-(diethyl amino) phenyl](2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium inner salt sodium salt (Isosulfan blue) of formula I. It also relates to highly pure novel crystalline form of Isosulfan blue hydrate and its process for the preparation thereof. It also relates to an improved process for the preparation of Isosulfan blue sodium hydrate having not more than 0.2% of desethyl impurity of formula A.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: July 28, 2020
    Assignee: BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
    Inventors: Manik Reddy Pullagurla, Mecheril Valsan Nanda Kumar, Bhaskar Reddy Pitta, Suresh Babu Namana, Jagadeesh Babu Rangisetty, Sadashiv Choppari
  • Method for the synthesis of permethrin
    Patent number: 10647655
    Abstract: An improved method for the synthesis of substantially pure Permethrin having purity greater than 99.5% by Gas Chromatography provided. The embodiments also relates to a purification process of Permethrin by recrystallization from methanol-water mixture.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: May 12, 2020
    Assignee: BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
    Inventors: Manik Reddy Pullagurla, Mecheril Valsan Nanda Kumar, Madhusudhana Rao Veligetla, Jagadeesh Babu Rangisetty
  • Novel Process for the Preparation of Gadolinium Complex of (4S)-4-(4-Ethoxybenzyl)-3,6,9-Tris(Carboxylatomethyl)-3,6,9-Triazaundecanedioic Acid Disodium (Gadoxetate Disodium)
    Publication number: 20200123178
    Abstract: The present invention discloses a novel process for the preparation of gadolinium complex of (4 S)-4-(4-Ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanedioic acid disodium of formula 1 and novel intermediates thereof.
    Type: Application
    Filed: May 30, 2017
    Publication date: April 23, 2020
    Applicant: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy PULLAGURLA, Bhaskar Reddy PITTA, Suresh Babu NAMANI, Jagadeesh Babu RANGISETTY
  • Process for the preparation of pasireotide
    Patent number: 10556924
    Abstract: The present invention relates to a novel process for the preparation of Pasireotide of formula 11 [Cyclo [Phe-{4-(OCO—NH—CH2—CH2—NH2)) Pro}-Phg-DTrp-Lys-Tyr(Bzl)]]. The invention also relates to a novel intermediate compound of formula 8 and process thereof which is used for preparation of compound of formula 11.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: February 11, 2020
    Assignee: BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
    Inventors: Manik Reddy Pullagurla, Radha Nagarapu, Jagadeesh Babu Rangisetty
  • Process for the preparation of tavaborole, its novel polymorphic forms and the polymorphs thereof
    Patent number: 10435419
    Abstract: The invention relates to novel process for preparation of Tavaborole. The invention also relates to novel polymorphic forms of Tavaborole and process for preparation of those polymorphic forms. The invention also relates to process for purification of Tavaborole to obtain the Tavaborole in significantly high yield and substantially pure form.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: October 8, 2019
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Mecheril Valsan Nanda Kumar, Bhaskar Reddy Pitta, Jagadeesh Babu Rangisetty
  • Process for the preparation of (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxo-pentan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamide
    Patent number: 10329325
    Abstract: Novel methods for preparation of Carfilzomib and intermediates thereof with high stereo selection are reported. The synthetic procedures result in substantially pure Carfilzomib (I).
    Type: Grant
    Filed: August 29, 2015
    Date of Patent: June 25, 2019
    Assignee: Biophore India Pharmaceuticals Pvt. Ltd
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nanda Kumar, Surya Bala Subrahmanyam Pendyala, Bhaskar Reddy Pitta
  • Novel Process for the Preparation of Tavaborole, Its Novel Polymorphic Forms and the Polymorphs Thereof
    Publication number: 20190119306
    Abstract: The invention relates to novel process for preparation of Tavaborole. The invention also relates to novel polymorphic forms of Tavaborole and process for preparation of those polymorphic forms. The invention also relates to process for purification of Tavaborole to obtain the Tavaborole in significantly high yield and substantially pure form.
    Type: Application
    Filed: July 21, 2016
    Publication date: April 25, 2019
    Applicant: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy PULLAGURLA, Mecheril Valsan NANDA KUMAR, Bhasakar Reddy PITTA, Jagadeesh Babu RANGISETTY
  • Process for the purification of polyaminocarboxylates
    Patent number: 10106489
    Abstract: The present invention relates to an improved process for the purification of polyaminocarboxylates such as DOTA, DTPA, DO3A-butrol, BOPTA.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: October 23, 2018
    Assignee: Biophore India Pharmaceuticals Pvt. Ltd.
    Inventors: Jagadeesh Babu Rangisetty, Manik Reddy Pullaguria, Rajesh Bhudeti
  • Process for the synthesis of Dabigatran Etexilate and its intermediates
    Patent number: 10077251
    Abstract: The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: September 18, 2018
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar
  • Process for the synthesis of melphalan and the hydrochloride salt
    Patent number: 9963422
    Abstract: The present invention relates to an improved process for the preparation of Melphalan, more specifically the invention relates to an efficient process for the preparation of substantially pure Melphalan hydrochloride (I).
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: May 8, 2018
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar, Madhava Reddy Vedururi, Sreenu Samireddi
  • Process for the Preparation of (S)-4-Methyl-N-((S)-1-(((S)-4-Methyl-1-((R)-2-Methyloxiran-2-YL)-1-OXO Pentan-2-YL) Amino)-1-OXO-3-Phenylpropan-2-YL)-2-((S)-2-(2-Morpholinoacetamido)-4-Phenylbutanamido) Pentanamide
    Publication number: 20170298093
    Abstract: Novel methods for preparation of Carfilzomib and intermediates thereof with high stereo selection are reported. The synthetic procedures result in substantially pure Carfilzomib (I).
    Type: Application
    Filed: August 29, 2015
    Publication date: October 19, 2017
    Applicant: Biophore India Pharmaceuticals Pvt. Ltd
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nanda Kumar, Surya Bala Subrahmanyam Pendyala, Bhaskar Reddy Pitta
  • Polymorph of regadenoson
    Patent number: 9624258
    Abstract: The invention provides a novel polymorph of Regadenoson. More particularly, the invention provides propylene glycol solvate of Regadenoson. The invention also provides a process for the preparation of propylene glycol solvate of Regadenoson.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: April 18, 2017
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Jagadeesh Babu Rangisetty, Manik Reddy Pullagurla, Mecheril Valsan Nandakumar, Dokula Neelam Naidu
  • Process for the preparation of (1-{9-[(4S, 2R, 3R, 5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminopurin-2-yl}pyrazole-4-yl)-N-methylcarboxamide
    Patent number: 9580457
    Abstract: The present invention relates to a novel process for the preparation of (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminopurin-2-yl}pyrazole-4-yl)-N-methylcarboxamide.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: February 28, 2017
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar
  • Process for the synthesis of dabigatran and its intermediates
    Patent number: 9533971
    Abstract: The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: January 3, 2017
    Assignee: Biophore India Pharmaceuticals PVT. Ltd
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar