Patents Assigned to Biophram (UK) Limited
  • Collagen-specific enzyme with platelet aggregation inhibition properties
    Patent number: 5139944
    Abstract: The collagenase is like tissue collagenases in that it cleaves collagen at a single site. The collagenase which has a molecular weight of about 50 k daltons, specifically inhibits collagen-induced platelet aggregation, with substantially no effect on platelet count or size, and may be used alone or together with another platelet aggregation inhibitor. The latter may also be a leech-derived biochemical, such as an apyrase, or an inhibitor of the release of platelet aggregation factor by leucocytes.
    Type: Grant
    Filed: January 30, 1991
    Date of Patent: August 18, 1992
    Assignees: Biophram (UK) Limited, Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Roy T. Sawyer, Meir Rigbi, Haim Levy, Fuad Iraqi