Patents Assigned to Biophysica, Inc.
-
Patent number: 7763288Abstract: Skin care compositions and methods are provided comprising a highly hydrophobic substance, an alkaryl polyfluorocarbon, particularly a substituted phenyl-polyfluoroacylamino propanamide, an alkanol and refined oils and the oil triglyceride fractions in sufficient amount to provide substantial homogeneity. When employed for hirsutism, optionally antioxidants and moisturizer are added. For use against wrinkles, additionally vitamins, antioxidants and a mixture of extracts of naturally occurring substances are present.Type: GrantFiled: June 6, 2008Date of Patent: July 27, 2010Assignee: Biophysica, Inc.Inventors: Milos Sovak, Allen L. Seligson, Jiri Prokop
-
Publication number: 20080260875Abstract: Skin care compositions and methods are provided comprising a highly hydrophobic substance, an alkaryl polyfluorocarbon, particularly a substituted phenyl-polyfluoroacylamino propanamide, an alkanol and refined oils and the oil triglyceride fractions in sufficient amount to provide substantial homogeneity. When employed for hirsutism, optionally antioxidants and moisturizer are added. For use against wrinkles, additionally vitamins, antioxidants and a mixture of extracts of naturally occurring substances are present.Type: ApplicationFiled: June 6, 2008Publication date: October 23, 2008Applicant: BIOPHYSICA, INC.Inventors: Milos Sovak, Allen L. Seligson, Jiri Prokop
-
Patent number: 6828458Abstract: Compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2,2-perfluoroacylamino)propionamide) applied topically, specifically inhibits and/or eliminates cutaneous androgen receptors and thus finds cosmetic use in skin afflictions associated with excess androgens such as hair effluvium, hirsutism, acne and androgenic alopecia.Type: GrantFiled: May 25, 2000Date of Patent: December 7, 2004Assignee: Biophysica, Inc.Inventors: Milos Sovak, Allen L. Seligson, Brian Campion, Jason W. Brown
-
Publication number: 20040014732Abstract: Compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2,2-perfluoroacylamino)propionamide) applied topically, specifically inhibits and/or eliminates cutaneous androgen receptors and thus finds cosmetic use in skin afflictions associated with excess androgens such as hair effluvium, hirsutism, acne and androgenic alopecia.Type: ApplicationFiled: May 25, 2000Publication date: January 22, 2004Applicant: Biophysica, Inc.Inventors: Milos Sovak, Allen L Seligson, Brian Campion, Jason W Brown
-
Patent number: 6472415Abstract: Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find use in indications associated with the androgen receptor, such as cell hyperplasia dependent on androgens, hirsutism, acne and androgenetic alopecia.Type: GrantFiled: February 11, 2000Date of Patent: October 29, 2002Assignee: Biophysica, Inc.Inventors: Milos Sovak, Allen L. Seligson, James Gordon Douglas, III, Brian Campion, Jason W. Brown
-
Patent number: 6184249Abstract: Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find use in the therapy of indications associated with the androgen receptor, such as, hirsutism, acne and androgenetic alopecia, and in the therapy and diagnosis of cell hyperplasia dependent on androgens.Type: GrantFiled: December 18, 1998Date of Patent: February 6, 2001Assignee: Biophysica, Inc.Inventors: Milos Sovak, Allen L. Seligson, James Gordon Douglass, III, Brian Campion, Jason W. Brown
-
Patent number: 6123928Abstract: Novel polymeric biologically inert compositions and their intermediates, as well as sunscreen formulations comprising them and making them invisible, are provided for broad range protection from ultraviolet radiation. Acryl polymers comprising at least two different ultraviolet absorbing moieties having different light absorbing ranges are employed in conjunction with other monomers to provide sunscreen polymers as microparticles. The polymer microparticles, once imbibed with carrier compounds, change the refractive index, thus providing invisible sunscreen formulations which offer enhanced protection without adverse physiological effects.Type: GrantFiled: July 21, 1998Date of Patent: September 26, 2000Assignee: Biophysica, Inc.Inventors: Milos Sovak, Ronald C. Terry, James G. Douglass, III, Farid Bakir, Jason Brown, Peter Cugley
-
Patent number: 6072069Abstract: Novel non-ionic contrast media are provided, which fulfill the requirements for x-ray visualization media, while being biodegradable. The compounds are characterized by being triiodo-3,5-diaminobenzoic acid derivatives, where the functional groups are derivatized with hydroxyalkyl groups and the amino functionalities are further derivatized with acyl substituents of one carbon acids. Also, triiodophloroglucinol oxyalkyl substituted derivatives are provided.Type: GrantFiled: November 4, 1998Date of Patent: June 6, 2000Assignee: Biophysica, Inc.Inventors: Milos Sovak, Allen L. Seligson, James Gordon Douglass, III
-
Patent number: 5741924Abstract: Novel polymeric compositions and their intermediates are provided, providing for broad range protection from ultraviolet radiation. Acryl polymers comprising at least two different ultraviolet absorbing moieties having different light absorbing ranges are employed in conjunction with another hydrophilic monomer to provide sunscreen formulations for invisibility, and enhanced protection, without deleterious effects in the dermis.Type: GrantFiled: June 14, 1995Date of Patent: April 21, 1998Assignee: Biophysica Inc.Inventors: Milos Sovak, Ronald Calvin Terry, James Gordon Douglass, III, Farid Bakir
-
Patent number: 5656651Abstract: Substituted phenylthiohydantoins are provided for use in detecting the presence of tumor cells having androgenic receptors and providing for cytostatic and cytotoxic activity toward such cells. The subject compounds provide for vehicles for specific targeting to the androgenic receptor containing cells of cytostatic and/or cytotoxic agents, heavy or light radioactive or radioopaque atoms, and the like for detection and treatment of cancer cells involving androgenic receptors or blocking androgenic receptors.Type: GrantFiled: June 16, 1995Date of Patent: August 12, 1997Assignee: Biophysica Inc.Inventors: Milos Sovak, Jerome C. Bressi, James Gordon Douglass, III, Brian Campion, Wolfgang Wrasidlo
-
Patent number: 5487885Abstract: Novel polymeric compositions and their intermediates are provided, providing for broad range protection from ultraviolet radiation. Acryl polymers comprising at least two different ultraviolet absorbing moieties having different light absorbing ranges are employed in conjunction with another hydrophilic monomer to provide sunscreen formulations for invisibility, and enhanced protection, without deleterious effects in the dermis.Type: GrantFiled: December 9, 1993Date of Patent: January 30, 1996Assignee: Biophysica, Inc.Inventors: Milos Sovak, Ronald C. Terry, James G. Douglass, III, Farid Bakir