Abstract: The invention concerns a method for preparing an extract from a preparation of approximately 90% pure 20-hydroxyecdysone that comprises the following steps: g) Hot dissolution of approximately 90% pure 20-hydroxyecdysone in methanol, filtration and partial concentration, h) Addition of 1 to 5 volumes of acetone, i) Cooling to a temperature of between 0 and 5° C. while stirring, j) Filtration of the obtained precipitate, k) Successive rinses with acetone and water, and l) Drying.
Type:
Application
Filed:
April 30, 2018
Publication date:
May 14, 2020
Applicants:
BIOPHYTIS, SORBONNE UNIVERSITE
Inventors:
René LAFONT, Pierre DILDA, Waly DIOH, Philippe DUPONT, Susanna DEL SIGNORE, Stanislas VEILLET
Abstract: Disclosed is a method for the treatment, prevention and/or stabilisation of ARMD, Stargardt disease, pigmentary retinopathy and/or diabetic retinopathy, including the application of a 3-deoxyanthocyanidin of formula (I) in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X? are as defined, with the condition that at least one of R1, R2, R3, R4 or R5 is a hydroxyl and at least one of R8, R9, R10 or R11 is a hydroxyl.
Type:
Grant
Filed:
May 27, 2016
Date of Patent:
December 24, 2019
Assignees:
BIOPHYTIS, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
Abstract: A method of photoprotecting cells of the retinal pigment epithelium (EPR) in mammals using a composition having norbixin. The norbixin is produced by purification from an extract of Bixa orellana seeds.
Type:
Grant
Filed:
April 28, 2016
Date of Patent:
June 11, 2019
Assignees:
BIOPHYTIS, SORBONNE UNVERSITÉ
Inventors:
René Lafont, Stanislas Veillet, José-Alain Sahel, Valérie Fontaine, Pierre-Paul Elena
Abstract: Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.
Type:
Grant
Filed:
April 9, 2018
Date of Patent:
June 11, 2019
Assignees:
BIOPHYTIS, SORBONNE UNVERSITÉ
Inventors:
René Lafont, Waly Dioh, Sophie Raynal, Stanislas Veillet, Franck Lepifre, Jean-Denis Durand
Abstract: Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.
Type:
Grant
Filed:
May 20, 2015
Date of Patent:
April 10, 2018
Assignees:
BIOPHYTIS, UNIVERSITÉ PARIS 6 PIERRE ET MARIE CURIE
Inventors:
René Lafont, Waly Dioh, Sophie Raynal, Stanislas Veillet, Franck Lepifre, Jean-Denis Durand
Abstract: The invention relates to the use of norbixin and an urucum extract enriched in bixin and/or norbixin as a food. The invention also provides a food preparation comprising norbixin, bixin or an extract comprising at least bixin or norbixin, the preparation being intended to be administered orally, for the protection of mammalian skin against UV-radiation.
Type:
Grant
Filed:
June 25, 2010
Date of Patent:
November 3, 2015
Assignees:
INSTITUT BIOPHYTIS SAS, UNIVERSITE PIERRE ET MARIE CURIE
Inventors:
Stanislas Veillet, René Lafont, Waly Dioh
Abstract: For reducing the negative effects of the metabolic syndrome on mammal organisms, it is proposed to use phytoecdysones for diminishing the fat body mass in individuals, notably with a weight excess. Phytoecdysones are advantageously incorporated into a food composition. The phytoecdysones can come from food plants, such as quinoa.
Type:
Grant
Filed:
November 19, 2008
Date of Patent:
August 7, 2012
Assignees:
Institut Biophytis SAS, Universite Pierre et Marie Curie, Centre National de la Recherche Scientifique (CNRS)
Abstract: For reducing the negative effects of the metabolic syndrome on mammal organisms, it is proposed to use phytoecdysones for diminishing the fat body mass in individuals, notably with a weight excess. Phytoecdysones are advantageously incorporated into a food composition. The phytoecdysones can come from food plants, such as quinoa.
Type:
Application
Filed:
November 19, 2008
Publication date:
February 10, 2011
Applicants:
INSTITUT BIOPHYTIS SAS, UNIVERSITE PIERRE ET MARIE CURIE