Patents Assigned to Biopolymer Engineering
  • Patent number: 8530642
    Abstract: Particulate ?-glucan is solubilized at elevated pressure and temperature to form particulate-soluble ?-glucan. The particulate-soluble ?-glucan is capable of being dried to a powder form and subsequently re-solubilized.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: September 10, 2013
    Assignee: Biopolymer Engineering, Inc.
    Inventor: Donald J. Cox
  • Patent number: 7786094
    Abstract: The present invention provides a means to broadly protect the military and the public from injury from biological warfare weapons, particularly infective agents such as anthrax. Beta (1,3)-glucans, particularly whole glucan particles, PGG-Glucan, and microparticulate glucan, provide general immune enhancement, thereby increasing the body's ability to defend against a wide variety of biological threats. Beta (1,3)-glucans have been shown to increase the resistance to infection by anthrax and other infectious organisms when administered before and after infection. The anti-infective mechanism of ?(1,3)-glucan appears to involve stimulation of the innate immune system through increased cytokine release and CR3 receptor activation. Beta (1,3)-glucan is pharmaceutically stable, relatively compact, and can also be used without significant side effects. Beta (1,3)-glucan can also enhance the effectiveness of other medical countermeasures such as antibiotics, vaccines, and immune antibodies.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: August 31, 2010
    Assignee: Biopolymer Engineering, Inc.
    Inventor: Gary R. Ostroff
  • Publication number: 20100166751
    Abstract: The present invention relates to methods of using whole glucan particles and complement activating antibodies for antitumor therapy. Whole glucan particles enhance the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. This binding enhances innate immune system cytotoxicity, as well as stimulating the release of activating cytokines.
    Type: Application
    Filed: November 9, 2009
    Publication date: July 1, 2010
    Applicants: Biopolymer Engineering (d/b/a Biothera), University of Louisville Research Foundation, Inc.
    Inventors: Gary R. Ostroff, Gordon D. Ross, Trunetta Jo Dockter Ross
  • Patent number: 7566704
    Abstract: The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble ?-glucan composition comprising ?-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: July 28, 2009
    Assignee: Biopolymer Engineering, Inc.
    Inventors: Myra L. Patchen, Spiros Jamas, D. Davidson Easson, Jr., Gary R. Ostroff
  • Publication number: 20090163439
    Abstract: The invention relates to methods for treating and preventing radiation and/or chemotherapy related injury and/or afflictions, such as myelosuppression and decreased macrophage activity, by administering a prophylactically or therapeutically effective amount of particulate, bioavailable ?(1,3; 1,6) glucan. The invention also relates to methods in which ?(1,3; 1,6) glucan is provided in the form of whole glucan particles, microparticulate ?-glucan particles or a combination thereof.
    Type: Application
    Filed: July 8, 2008
    Publication date: June 25, 2009
    Applicants: Biopolymer Engineering, University of Louisville Research Foundation, Inc.
    Inventors: Gary R. Ostroff, Gordon D. Ross, Trunetta Jo Dockter Ross
  • Patent number: 7022685
    Abstract: The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble ?-glucan composition comprising ?-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).
    Type: Grant
    Filed: March 7, 2002
    Date of Patent: April 4, 2006
    Assignee: Biopolymer Engineering, Inc.
    Inventors: Myra L. Patchen, Spiros Jamas, D. Davidson Easson, Jr., Gary R. Ostroff
  • Publication number: 20050245480
    Abstract: The invention relates to methods for treating and preventing radiation and/or chemotherapy related injury and/or afflictions, such as myelosuppression and decreased macrophage activity, by administering a prophylactically or therapeutically effective amount of particulate, bioavailable ?(1,3; 1,6) glucan. The invention also relates to methods in which ?(1,3; 1,6) glucan is provided in the form of whole glucan particles, microparticulate ?-glucan particles or a combination thereof.
    Type: Application
    Filed: February 11, 2005
    Publication date: November 3, 2005
    Applicants: Biopolymer Engineering, Inc., University of Louisville Research Foundation
    Inventors: Gary Ostroff, Gordon Ross, Trunetta Ross
  • Patent number: 6630310
    Abstract: A preparation containing a receptor for underivatized, aqueous soluble &bgr;(1-3)-glucan is disclosed, along with characterization of the receptor for underivatized, aqueous soluble &bgr;(1-3)-glucan. Also described are assays for identifying agents which alter the effect of underivatized, aqueous soluble &bgr;(1-3)-glucan on activation of signal transduction pathways and agents identified thereby, as well as assays for assessing the specificity of carbohydrate:glycolipid interactions.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: October 7, 2003
    Assignee: Biopolymer Engineering Pharmaceutical, Inc.
    Inventors: Eric Wakshull, William M. Mackin, Janet Zimmerman
  • Publication number: 20020143174
    Abstract: The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble &bgr;-glucan composition comprising &bgr;-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).
    Type: Application
    Filed: March 7, 2002
    Publication date: October 3, 2002
    Applicant: Biopolymer Engineering, Inc.
    Inventors: Myra L. Patchen, Spiros Jamas, D. Davidson Easson, Gary R. Ostroff
  • Patent number: 6369216
    Abstract: The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble &bgr;-glucan composition comprising &bgr;-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: April 9, 2002
    Assignee: Biopolymer Engineering Pharmaceutical, Inc.
    Inventors: Myra L. Patchen, Spiros Jamas, D. Davidson Easson, Jr., Gary R. Ostroff