Abstract: The present disclosure discloses a mass spectrometry based method for detecting serum metabolite, and relates to the technical field of mass spectrometric detection.

Abstract: A prosthetic assembly and a method of assembling same. The prosthetic assembly includes a base component with at least one engagement surface. A pyrolytic carbon component includes at least one engagement surface. The pyrolytic carbon component is elastically deformed to mechanically interlock with the engagement surface on the base component. The pyrolytic carbon component retains at least a portion of the deformation stress created during coupling with the base component.

Abstract: A method and apparatus for replacing an articular surface of a bone. The implant includes at least one head with a bore and a lateral articular surface generally perpendicular to an axis of the bore. A holding element includes a stem at a proximal end adapted to attach to the bone. A member at a distal end of the holding device is adapted to engage with the bore in the head so that the lateral articular surface is positioned to engage transverse loads. The bore permits limited lateral translation of the head in at least one direction generally perpendicular to a longitudinal axis of the member.

Abstract: The implant comprises a stem (10) terminating in a head (20). The stem is adapted to be inserted in the metacarpus of the thumb and the head to be disposed in a space obtained particularly by removing at least a portion of the trapezium. The surface of the head is constituted by a base (201) connected to the stem and adapted to rest on the proximal end of the metacarpus, a distal surface portion (202) opposite the base and serving as a contact surface with the bone located facing the proximal end of the metacarpus, and a connecting portion (203) connecting the base and the distal surface portion of the head. The distal surface portion (202) of the head is inclined relative to a longitudinal axis (104) of the stem by a predetermined angle (?), such that, when the stem (10) is mounted straight in the metacarpus, the distal surface portion (202) of the head can be located in varus.

Abstract: The implant includes a stem terminating in a head. The stem is adapted to be inserted in the metacarpus of the thumb and the head to be disposed in a space obtained particularly by removing at least a portion of the trapezium. The surface of the head is constituted by a base connected to the stem and adapted to rest on the proximal end of the metacarpus, a distal surface portion opposite the base and serving as a contact surface with the bone located facing the proximal end of the metacarpus, and a connecting portion connecting the base and the distal surface portion of the head. The distal surface portion of the head is inclined relative to a longitudinal axis of the stem by a predetermined angle, such that, when the stem is mounted straight in the metacarpus, the distal surface portion of the head can be located in varus.

Abstract: A conical coupling of a male member (10) and a female member (11), the male member (10) comprising a cone (12) ensleeved in a truncated conical portion (15) of a corresponding recess (14) formed in the female member (11), is characterized in that the female member (11) is made of a material having a Young's modulus at most equal to about 35 GPa and at most equal to that of the material from which the male member (10) is made, and in that a surface (13) of the male member perpendicular to the axis (A1) of the coupling is in contact with a surface (17) of the female member also perpendicular to the coupling axis such that the male and female members (10, 11) are in axial abutment against each other. The female member (11) is for example of pyrocarbon and the male member (10) of metal, ceramic or pyrocarbon.

Abstract: The present invention provides methods for determining genetic haplotype comprising identifying target nucleic acids or gene fragments, said nucleic acids or gene fragments comprising a haplotype of interest, and detecting at least one parameter displayed by one of a primer-dependent transcript, a probe, or a primer-dependent transcript/probe complex. Further provided are methods for determining genetic haplotype comprising labeling nucleic acids or gene fragments with a least one probe, and detecting the velocity of the nucleic acid molecule or gene fragment by sequentially measuring at least one parameter displayed by the probes.

Abstract: The implant has at least one contact surface portion, made of pyrolytic carbon, designed to be in mobile contact with at least one bony surface when the implant is implanted in a patient. Furthermore, the implant is free from any attaching means, so that it remains free with respect to the at least one bony surface when implanted in the patient.