Abstract: The present invention relates to thiamine controlled-release pharmaceutical compositions and their use in medicine for resolving absorption defects or deficiencies of thiamine itself from the organism. Said compositions have revealed to be useful in the treatment of cerebral pathologies connected with learning and memorizing processes. In particular, said compositions have revealed to be useful in the treatment of the Alzheimer's pathology, preferably in the forms of slight-medium intensity.

Abstract: The present invention describes how to obtain composite products comprising an active substance supported by a carrier, in which the carrier is the linear copolymer of N-vinyl-2-pyrrolidone with vinyl acetate. The composite products are obtained by co-grinding of the dry mixture of the active substance and of the aforesaid carrier. The composite products thus obtained have better chemical-physical properties (lower melting enthalpy and/or lower melting temperature of the active substance) and a higher dissolution speed with respect to composite products obtained with the same-co-grinding time with other carriers used in prior techniques. Furthermore, the composite products obtained with the technique according to the present invention have the appearance of powders that are easier to work from a pharmaceutical point of view (flow, compression) with respect to composite products previously obtained with other carriers.