Patents Assigned to Bioproject
  • Benzazole derivatives as histamine H4 receptor ligands
    Patent number: 8802664
    Abstract: The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: August 12, 2014
    Assignee: Bioproject
    Inventors: Isabelle Berrebi-Bertrand, Xavier Billot, Thierry Calmels, Marc Capet, Denis Danvy, Stephane Krief, Olivier Labeeuw, Jeanne-Marie Lecomte, Nicolas Levoin, Xavier Ligneau, Philippe Robert, Jean-Charles Schwartz
  • Combinations of an anti emetic agent and an enkephalinase inhibitor
    Patent number: 8222294
    Abstract: The present invention concerns combinations of an anti-emetic agent and an enkephalinase inhibitor for use in methods for treating diarrhea and/or gastroenteritis.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: July 17, 2012
    Assignee: Bioproject
    Inventors: Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • Non-imidazole alkylamines as histamine H-receptor ligands and their therapeutic applications
    Patent number: 7169928
    Abstract: Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position; R1 and R2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H3-receptors of histamine.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: January 30, 2007
    Assignee: Societe Civile Bioproject
    Inventors: Jean-Charles Schwartz, Jean-Michel Arrang, Monique Garbarg, Jeanne-Marie Lecomte, Xavier Ligneau, Walter G. Schunack, Holger Stark, Charon Robin Ganellin, Fabien Leurquin, Sigurd Elz
  • Polymorphic forms of fasidotril, their methods of preparation and pharmaceutical compositions comprising them
    Patent number: 6767921
    Abstract: The subject of the present invention is the various polymorphic forms I, II, III, IV of benzyl (S,S)-2-(2-acetylsulphanylmethyl-3-benzo[1,3]dioxol-5-ylpropionyl-amino)propionate, hereinafter called Fasidotril, their methods of preparation and novel pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: July 27, 2004
    Assignee: Bioproject
    Inventors: Marc Capet, Gérard Coquerel, Denis Danvy, Jeanne-Marie Lecomte, Marie-Noëlle Petit, Jean-Charles Schwartz
  • Process for the synthesis of .alpha.-substituted acrylic acids and their application
    Patent number: 5945548
    Abstract: Process for the synthesis of .alpha.-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II).
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: August 31, 1999
    Assignee: Societe Civile Bioproject
    Inventors: Pierre Duhamel, Lucette Duhamel, Denis Danvy, Thierry Monteil, Jeanne-Marie Lecomte, Jean-Charles Schwartz
  • Amino acid, derivatives, processes for their preparation and their therapeutic application
    Patent number: 5612371
    Abstract: New amino acid derivatives, processes for their preparation and their therapeutic application.Amino acid derivatives corresponding to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.
    Type: Grant
    Filed: July 18, 1994
    Date of Patent: March 18, 1997
    Assignee: Societe Civile Bioproject
    Inventors: Denis Danvy, Thierry Monteil, Christophe Lusson, Jean-Charles Schwartz, Claude Gros, Nadine Noel, Jeanne-Marie Lecomte, Pierre Duhamel, Lucette Duhamel
  • Histamine derivative, process for preparing it and its therapeutic use
    Patent number: 5034539
    Abstract: The present invention relates to .alpha.,.beta.-dimethylhistamine, of the rmula: ##STR1## in racemic form, or an optical isomer form or mixture of diastereoisomers and its acid addition salts. It may be prepared from an alkyl 2-amino 3-(1H-imidazol-4-yl)-carboxylate.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: July 23, 1991
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Bioproject
    Inventors: Jean-Michel Arrang, Monique Garbarg, Walter Schunack, Jean-Charles Schwartz, Ralph O. Lipp