Patents Assigned to Bioption AB
  • DNA expression systems based on alphaviruses
    Patent number: 6770283
    Abstract: The disclosure describes recombinant alphavirus RNA molecules and expression of heterologous proteins therefrom in animal cells. Recombinant alphaviruses of the present invention, when made to express an antigenic protein, can be administered as vaccines.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: August 3, 2004
    Assignee: Bioption AB
    Inventors: Henrik Garoff, Peter Liljeström
  • Alphavirus expression vector
    Patent number: 6692750
    Abstract: The present invention is directed to alphavirus expression vectors comprising at least part of an alphavirus genome and heterologous RNA inserted downstream of an alphavirus base sequence having translation enhancing activity. Such vectors can be used to achieve enhanced levels of expression of DNA or cDNA coding for a desired product and being complementary to said heterologous RNA after introduction of said vector in eukaryotic cells in cell culture or in a living body. The expression product may have therapeutic or prophylactic activity.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: February 17, 2004
    Assignee: Bioption AB
    Inventors: Mathilda Sjöberg, Maarit Suomalainen, Henrik Garoff
  • Alphavirus cDNA vectors
    Patent number: 6566093
    Abstract: The present invention is related to polynucleotide molecules and to their use for production of desired products after introduction into human or animal cells. In addition, the present invention is concerned with pharmaceutical compositions comprising said polynucleotide molecules and their use in prophylactic or therapeutic treatment methods. The present invention is also related to use of such polynucleotide molecules in animals to achieve expression of desired products, which can be recovered from the animal but do not give rise to any beneficial, e.g. therapeutic, activity in the animal. More specifically, the present invention is directed to alphaviruus cDNA vectors comprised of recombinant cDNA consisting of cDNA derived from an alphavirus and heterologous, i.e. foreign, cDNA encoding a desired substance.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: May 20, 2003
    Assignee: Bioption AB
    Inventors: Peter Liljeström, Henrik Garoff
  • DNA expression systems based on alphaviruses
    Publication number: 20020151067
    Abstract: The disclosure describes recombinant alphavirus RNA molecules and expression of heterologous proteins therefrom in animal cells. Recombinant alphaviruses of the present invention, when made to express an antigenic protein, can be administered as vaccines.
    Type: Application
    Filed: July 10, 2001
    Publication date: October 17, 2002
    Applicant: Bioption AB
    Inventors: Henrik Garoff, Peter Liljestrom
  • Alphavirus expression vector
    Patent number: 6224879
    Abstract: The present invention is directed to alphavirus expression vectors comprising at least part of an alphavirus genome and heterologous RNA inserted downstream of an alphavirus base sequence having translation enhancing activity. Such vectors can be used to achieve enhanced levels of expression of DNA or cDNA coding for a desired product and being complementary to said heterologous RNA after introduction of said vector in eukaryotic cells in cell culture or in a living body. The expression product may have therapeutical or prophylactic activity.
    Type: Grant
    Filed: November 18, 1996
    Date of Patent: May 1, 2001
    Assignee: Bioption AB
    Inventors: Mathilda Sjöberg, Maarit Suomalainen, Henrik Garoff
  • DNA expression systems based on alphaviruses
    Patent number: 5739026
    Abstract: The disclosure describes recombinant alphavirus RNA molecules and expression of heterologous proteins therefrom in animal cells. Recombinant alphaviruses of the present invention, when made to express an antigenic protein, can be administered as vaccines.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: April 14, 1998
    Assignee: Bioption AB
    Inventors: Henrik Garoff, Peter Liljestrom