Abstract: Processes and compositions for the therapeutic treatment of pathogenic Gram-negative bacterial infection are provided whereby argininosuccinate synthetase or PEGylated argininosuccinate synthetase is administered to a subject to inactivate endotoxin thereby reducing the likelihood of bacterial sepsis and improving patient outcome.
Type:
Grant
Filed:
June 16, 2017
Date of Patent:
May 12, 2020
Assignee:
BioRegency, Inc.
Inventors:
Stanislav I. Svetlov, Victor Prima, Alvin Wang, Gabriel Molina, Kevin Ka-wang Wang