Patents Assigned to Biorep Technologies, Inc.
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Patent number: 11453004Abstract: A fluidic manifold cartridge includes a plurality of source fluid inlets and fluid outlets. A plurality of fluid input flow channels are provided. Each fluid inlet is in fluid communication with a fluid input flow channel. Each fluid input flow channel directs fluid from the fluid inlet past a plurality of valves. A plurality of fluid output flow channels are in fluid communication with a fluid outlets. Each valve includes a valve seat, a portion of membrane, and a control fluid opening. Each valve has an open and closed condition. The valve in the open condition directs fluid from a fluid input flow channel to a fluid output flow channel. The control fluid opening directs control fluid to move the membrane so as to change the valve between the open and closed conditions. Systems and methods for fluidic manifold are also disclosed.Type: GrantFiled: November 4, 2019Date of Patent: September 27, 2022Assignee: BIOREP TECHNOLOGIES, INC.Inventor: Felipe Echeverri
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Patent number: 10471427Abstract: A fluidic manifold cartridge includes a plurality of source fluid inlets and fluid outlets. A plurality of fluid input flow channels are provided. Each fluid inlet is in fluid communication with a fluid input flow channel. Each fluid input flow channel directs fluid from the fluid inlet past a plurality of valves. A plurality of fluid output flow channels are in fluid communication with a fluid outlets. Each valve includes a valve seat, a portion of membrane, and a control fluid opening. Each valve has an open and closed condition. The valve in the open condition directs fluid from a fluid input flow channel to a fluid output flow channel. The control fluid opening directs control fluid to move the membrane so as to change the valve between the open and closed conditions. Systems and methods for fluidic manifold are also disclosed.Type: GrantFiled: April 24, 2017Date of Patent: November 12, 2019Assignee: BIOREP TECHNOLOGIES, INC.Inventor: Felipe Echeverri
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Patent number: 9687241Abstract: An anastomosis device includes a stapler and an anvil. The stapler includes a clamp head with opposing first and second clamp jaws and a clamp actuator and clamp lock. Staple magazines are connected to the clamp jaws for retaining a plurality of staples in an array, and drivers are provided for moving the plurality of staples in the array out of the staple magazine. An anvil includes a clamp head with opposing first and second clamp jaws, a clamp actuator and a clamp lock. Anvil portions are connected to the clamp jaws. The stapler detachably engages to the anvil, and aligns the staple magazines with the anvils. The drivers are operated to move the staples from the staple magazines into contact with the anvil portions. A method for performing anastomosis is also disclosed.Type: GrantFiled: September 16, 2016Date of Patent: June 27, 2017Assignees: ZAKEASE SURGICAL, INC., BIOREP TECHNOLOGIES, INC.Inventors: Ramon E. Poo, Andreas G. Tzakis
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Patent number: 9108204Abstract: A centrifuge includes a container and at least one drive for rotating the container about its own axis and revolving the container about an axis of revolution and through a plane of revolution. At least one conduit extends from the container to a first or second side of the plane of revolution. The direction of rotation of the container is according to the left hand rule if the conduit extends to the first side of the plane of rotation, and according to the right hand rule if the conduit extends to the second side of the plane of rotation. The frequency of the container rotation is equal to the frequency of the container revolution. A centrifugal separator and a method for centrifuging a liquid are also disclosed. The invention provides for continuous centrifugation while prevent conduits into the container from getting tangled.Type: GrantFiled: June 11, 2014Date of Patent: August 18, 2015Assignee: BIOREP TECHNOLOGIES, INC.Inventors: Ramon E Poo, Felipe Echeverri
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Patent number: 8865427Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: GrantFiled: August 27, 2012Date of Patent: October 21, 2014Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Patent number: 8785178Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: GrantFiled: January 12, 2007Date of Patent: July 22, 2014Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Patent number: 8777084Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.Type: GrantFiled: January 8, 2013Date of Patent: July 15, 2014Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Andreas G. Tzakis
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Publication number: 20130040324Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: ApplicationFiled: August 27, 2012Publication date: February 14, 2013Applicants: University of Miami, Biorep Technologies, Inc.Inventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Patent number: 8348128Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.Type: GrantFiled: November 11, 2009Date of Patent: January 8, 2013Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Andreas G. Tzakis
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Patent number: 8263389Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles.Type: GrantFiled: June 30, 2010Date of Patent: September 11, 2012Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Publication number: 20110108602Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.Type: ApplicationFiled: November 11, 2009Publication date: May 12, 2011Applicants: Biorep Technologies, Inc., University of MiamiInventors: RAMON E. POO, Andreas G. Tzakis
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Publication number: 20110020856Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles.Type: ApplicationFiled: June 30, 2010Publication date: January 27, 2011Applicants: Biorep Technologies, Inc., University of MiamiInventors: RAMON E. POO, CAMILLO RICORDI, FELIPE ECHEVERRI, Over Cabrera, PER-OLOF BERGGREN
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Patent number: 7790437Abstract: An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.Type: GrantFiled: December 14, 2006Date of Patent: September 7, 2010Assignees: Biorep Technologies, Inc., The University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Patent number: 7713686Abstract: An organ preservation container includes a gas impermeable housing for containing an organ. At least two liquids having different densities and forming a liquid-liquid interface are also contained in the housing. A closure for hermetically sealing the housing is provided. A structure is provided within the housing for engaging the organ and for maintaining a portion of the organ at the liquid-liquid interface such that the organ will be maintained partially in both of the liquids. A method for preserving the organ is also described.Type: GrantFiled: December 3, 2004Date of Patent: May 11, 2010Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Patent number: 7655391Abstract: A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas therebetween. A method for shipping items in an aircraft is also disclosed.Type: GrantFiled: November 21, 2005Date of Patent: February 2, 2010Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Publication number: 20080286746Abstract: A perfusion apparatus for perfusing an organ includes a pump for pumping perfusion liquid though a perfusion liquid conduit, the conduit having an outlet. A pressure sensor senses the pressure of the perfusion liquid downstream of the pump and upstream of the outlet. A controller controls the output of the pump responsive to the pressure, so as to keep the pressure of the liquid reaching the organ substantially constant.Type: ApplicationFiled: May 17, 2007Publication date: November 20, 2008Applicants: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Publication number: 20080172022Abstract: An infusion container includes a main body portion with side walls, and top and bottom portions. The bottom portion has an included angle, the included angle being between 30-120 degrees. The included angle serves to channel cells to be infused into a patient out of the container, to reduce waste and damage to the cells. A method of infusion is also disclosed.Type: ApplicationFiled: January 11, 2007Publication date: July 17, 2008Applicants: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri
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Publication number: 20080168847Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: ApplicationFiled: January 12, 2007Publication date: July 17, 2008Applicants: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Publication number: 20080145833Abstract: An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.Type: ApplicationFiled: December 14, 2006Publication date: June 19, 2008Applicants: Biorep Technologies, Inc., University of MiamiInventors: RAMON E. POO, Camillo Ricordi
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Patent number: 7188994Abstract: A orbital shaker for cell extraction includes a digestion chamber and structure for translating the digestion chamber. Structure is also provided for rotating the digestion chamber. A method of performing cell extraction is also disclosed.Type: GrantFiled: February 24, 2003Date of Patent: March 13, 2007Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi