Patents Assigned to Biorep Technologies, Inc.
  • Patent number: 8865427
    Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: October 21, 2014
    Assignees: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
  • Patent number: 8785178
    Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: July 22, 2014
    Assignees: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
  • Patent number: 8777084
    Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: July 15, 2014
    Assignees: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Andreas G. Tzakis
  • Publication number: 20130040324
    Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
    Type: Application
    Filed: August 27, 2012
    Publication date: February 14, 2013
    Applicants: University of Miami, Biorep Technologies, Inc.
    Inventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
  • Patent number: 8348128
    Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: January 8, 2013
    Assignees: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Andreas G. Tzakis
  • Patent number: 8263389
    Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: September 11, 2012
    Assignees: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
  • Publication number: 20110108602
    Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.
    Type: Application
    Filed: November 11, 2009
    Publication date: May 12, 2011
    Applicants: Biorep Technologies, Inc., University of Miami
    Inventors: RAMON E. POO, Andreas G. Tzakis
  • Publication number: 20110020856
    Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles.
    Type: Application
    Filed: June 30, 2010
    Publication date: January 27, 2011
    Applicants: Biorep Technologies, Inc., University of Miami
    Inventors: RAMON E. POO, CAMILLO RICORDI, FELIPE ECHEVERRI, Over Cabrera, PER-OLOF BERGGREN
  • Patent number: 7790437
    Abstract: An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: September 7, 2010
    Assignees: Biorep Technologies, Inc., The University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi
  • Patent number: 7713686
    Abstract: An organ preservation container includes a gas impermeable housing for containing an organ. At least two liquids having different densities and forming a liquid-liquid interface are also contained in the housing. A closure for hermetically sealing the housing is provided. A structure is provided within the housing for engaging the organ and for maintaining a portion of the organ at the liquid-liquid interface such that the organ will be maintained partially in both of the liquids. A method for preserving the organ is also described.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: May 11, 2010
    Assignees: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi
  • Patent number: 7655391
    Abstract: A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas therebetween. A method for shipping items in an aircraft is also disclosed.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: February 2, 2010
    Assignees: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi
  • Publication number: 20080286746
    Abstract: A perfusion apparatus for perfusing an organ includes a pump for pumping perfusion liquid though a perfusion liquid conduit, the conduit having an outlet. A pressure sensor senses the pressure of the perfusion liquid downstream of the pump and upstream of the outlet. A controller controls the output of the pump responsive to the pressure, so as to keep the pressure of the liquid reaching the organ substantially constant.
    Type: Application
    Filed: May 17, 2007
    Publication date: November 20, 2008
    Applicants: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi
  • Publication number: 20080172022
    Abstract: An infusion container includes a main body portion with side walls, and top and bottom portions. The bottom portion has an included angle, the included angle being between 30-120 degrees. The included angle serves to channel cells to be infused into a patient out of the container, to reduce waste and damage to the cells. A method of infusion is also disclosed.
    Type: Application
    Filed: January 11, 2007
    Publication date: July 17, 2008
    Applicants: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri
  • Publication number: 20080168847
    Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.
    Type: Application
    Filed: January 12, 2007
    Publication date: July 17, 2008
    Applicants: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
  • Publication number: 20080145833
    Abstract: An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.
    Type: Application
    Filed: December 14, 2006
    Publication date: June 19, 2008
    Applicants: Biorep Technologies, Inc., University of Miami
    Inventors: RAMON E. POO, Camillo Ricordi
  • Patent number: 7188994
    Abstract: A orbital shaker for cell extraction includes a digestion chamber and structure for translating the digestion chamber. Structure is also provided for rotating the digestion chamber. A method of performing cell extraction is also disclosed.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: March 13, 2007
    Assignees: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi
  • Patent number: 7186549
    Abstract: A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas therebetween. A method for shipping items in an aircraft is also disclosed.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: March 6, 2007
    Assignees: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi
  • Publication number: 20050142532
    Abstract: A method for storing organs, cells, and tissues, includes the steps of providing a gas impermeable container; providing a preservation solution containing dissolved oxygen; placing the preservation solution into the container with the organ, cell or tissue; and hermetically closing said container. A system for storing organs, cells, and tissue includes a gas impermeable organ container for the organs, cells and tissue. A hermetically sealable solution container is provided for storing a preservation solution. The preservation solution contains dissolved oxygen. A dispensing structure is provided for placing the solution into the organ container. The preservation solution can include an oxygen-carrier solution and UW solution. The oxygen-carrier solution can be perfluorocarbon.
    Type: Application
    Filed: February 15, 2005
    Publication date: June 30, 2005
    Applicants: Biorep Technologies, Inc., University of Miami
    Inventors: Ramon Poo, Camillo Ricordi
  • Patent number: 6833270
    Abstract: An apparatus and method for extracting cells from organs in which a digestion chamber includes at least one inlet and at least one outlet, and a separator for retaining the organ and permitting the cells and the physiologically compatible medium to exit the outlet. The digestion chamber can also includes at least one agitation member having an interior with at least one void. An agitation member for extracting cells from organs is also disclosed.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: December 21, 2004
    Assignees: Biorep Technologies, Inc., The University of Miami
    Inventors: Ramon E. Poo, Camillo Ricordi