Patents Assigned to Biorep Technologies, Inc.
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Patent number: 8865427Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: GrantFiled: August 27, 2012Date of Patent: October 21, 2014Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Patent number: 8785178Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: GrantFiled: January 12, 2007Date of Patent: July 22, 2014Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Patent number: 8777084Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.Type: GrantFiled: January 8, 2013Date of Patent: July 15, 2014Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Andreas G. Tzakis
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Publication number: 20130040324Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided. A receptacle housing has a plurality of receptacles. A drive is connected to the receptacle housing for moving the receptacle housing. A programmable controller can be provided to control movement of the receptacle housing. The test liquid includes at least one stimuli for the cells. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: ApplicationFiled: August 27, 2012Publication date: February 14, 2013Applicants: University of Miami, Biorep Technologies, Inc.Inventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Patent number: 8348128Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.Type: GrantFiled: November 11, 2009Date of Patent: January 8, 2013Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Andreas G. Tzakis
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Patent number: 8263389Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles.Type: GrantFiled: June 30, 2010Date of Patent: September 11, 2012Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Publication number: 20110108602Abstract: A system for performing anastomosis includes a plurality of staples, an annular staple support having structure for holding the staples, and a staple closing device for closing the staples to secure the canal ends together. A method for performing anastomosis and staples for performing anastomosis are also disclosed.Type: ApplicationFiled: November 11, 2009Publication date: May 12, 2011Applicants: Biorep Technologies, Inc., University of MiamiInventors: RAMON E. POO, Andreas G. Tzakis
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Publication number: 20110020856Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A manifold having a plurality of liquid inlets, control valves, and liquid outlets can be provided so that the flow of liquids from source containers to the sample containers can be varied and controlled. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A programmable controller can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles.Type: ApplicationFiled: June 30, 2010Publication date: January 27, 2011Applicants: Biorep Technologies, Inc., University of MiamiInventors: RAMON E. POO, CAMILLO RICORDI, FELIPE ECHEVERRI, Over Cabrera, PER-OLOF BERGGREN
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Patent number: 7790437Abstract: An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.Type: GrantFiled: December 14, 2006Date of Patent: September 7, 2010Assignees: Biorep Technologies, Inc., The University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Patent number: 7713686Abstract: An organ preservation container includes a gas impermeable housing for containing an organ. At least two liquids having different densities and forming a liquid-liquid interface are also contained in the housing. A closure for hermetically sealing the housing is provided. A structure is provided within the housing for engaging the organ and for maintaining a portion of the organ at the liquid-liquid interface such that the organ will be maintained partially in both of the liquids. A method for preserving the organ is also described.Type: GrantFiled: December 3, 2004Date of Patent: May 11, 2010Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Patent number: 7655391Abstract: A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas therebetween. A method for shipping items in an aircraft is also disclosed.Type: GrantFiled: November 21, 2005Date of Patent: February 2, 2010Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Publication number: 20080286746Abstract: A perfusion apparatus for perfusing an organ includes a pump for pumping perfusion liquid though a perfusion liquid conduit, the conduit having an outlet. A pressure sensor senses the pressure of the perfusion liquid downstream of the pump and upstream of the outlet. A controller controls the output of the pump responsive to the pressure, so as to keep the pressure of the liquid reaching the organ substantially constant.Type: ApplicationFiled: May 17, 2007Publication date: November 20, 2008Applicants: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Publication number: 20080172022Abstract: An infusion container includes a main body portion with side walls, and top and bottom portions. The bottom portion has an included angle, the included angle being between 30-120 degrees. The included angle serves to channel cells to be infused into a patient out of the container, to reduce waste and damage to the cells. A method of infusion is also disclosed.Type: ApplicationFiled: January 11, 2007Publication date: July 17, 2008Applicants: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri
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Publication number: 20080168847Abstract: A perifusion device includes at least one sample container for cells, the sample container having an inlet and an outlet. The container receives test liquid through the inlet and discharges the liquid through the outlet. A receptacle housing has a plurality of receptacles for receiving fluid from the outlet of the sample container. A drive is connected to the receptacle housing for moving the receptacle housing such that liquid samples are collected sequentially from the outlet of the sample containers. A computer can be provided to control movement of the receptacle housing at predetermined times, and to record data identifying liquid samples in the receptacles. The test liquid includes at least one stimuli for the cells, which can be the presence, absence, or concentration of a compound in the liquid, or a physical property of the liquid such as temperature. The liquid collected in the receptacles is analyzed to determine the response of the cells to the stimuli.Type: ApplicationFiled: January 12, 2007Publication date: July 17, 2008Applicants: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi, Felipe Echeverri, Over Cabrera, Per-Olof Berggren
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Publication number: 20080145833Abstract: An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a motor and a battery to provide for rotation of the organ container during shipping.Type: ApplicationFiled: December 14, 2006Publication date: June 19, 2008Applicants: Biorep Technologies, Inc., University of MiamiInventors: RAMON E. POO, Camillo Ricordi
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Patent number: 7188994Abstract: A orbital shaker for cell extraction includes a digestion chamber and structure for translating the digestion chamber. Structure is also provided for rotating the digestion chamber. A method of performing cell extraction is also disclosed.Type: GrantFiled: February 24, 2003Date of Patent: March 13, 2007Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Patent number: 7186549Abstract: A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas therebetween. A method for shipping items in an aircraft is also disclosed.Type: GrantFiled: April 22, 2004Date of Patent: March 6, 2007Assignees: Biorep Technologies, Inc., University of MiamiInventors: Ramon E. Poo, Camillo Ricordi
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Publication number: 20050142532Abstract: A method for storing organs, cells, and tissues, includes the steps of providing a gas impermeable container; providing a preservation solution containing dissolved oxygen; placing the preservation solution into the container with the organ, cell or tissue; and hermetically closing said container. A system for storing organs, cells, and tissue includes a gas impermeable organ container for the organs, cells and tissue. A hermetically sealable solution container is provided for storing a preservation solution. The preservation solution contains dissolved oxygen. A dispensing structure is provided for placing the solution into the organ container. The preservation solution can include an oxygen-carrier solution and UW solution. The oxygen-carrier solution can be perfluorocarbon.Type: ApplicationFiled: February 15, 2005Publication date: June 30, 2005Applicants: Biorep Technologies, Inc., University of MiamiInventors: Ramon Poo, Camillo Ricordi
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Patent number: 6833270Abstract: An apparatus and method for extracting cells from organs in which a digestion chamber includes at least one inlet and at least one outlet, and a separator for retaining the organ and permitting the cells and the physiologically compatible medium to exit the outlet. The digestion chamber can also includes at least one agitation member having an interior with at least one void. An agitation member for extracting cells from organs is also disclosed.Type: GrantFiled: November 27, 2001Date of Patent: December 21, 2004Assignees: Biorep Technologies, Inc., The University of MiamiInventors: Ramon E. Poo, Camillo Ricordi