Patents Assigned to BioResponse, L.L.C.
-
Patent number: 11337961Abstract: Disclosed herein are self-emulsifying compositions and formulations of Dimdolylmethane (“DIM”) and certain derivatives of DIM, their uses and methods of making. In particular, the disclosed compositions comprise a DIM-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an HLB of greater than 7, and one or more co-surfactants with an HLB equal to or less than 7. In certain aspects of the invention, the compositions disclosed herein show improved bioavailability.Type: GrantFiled: September 1, 2020Date of Patent: May 24, 2022Assignee: Bioresponse, L.L.C.Inventors: Michael A. Zeligs, Irwin C. Jacobs
-
Patent number: 10799479Abstract: Disclosed herein are self-emulsifying compositions and formulations of Dimdolylmethane (“DIM”) and certain derivatives of DIM, their uses and methods of making. In particular, the disclosed compositions comprise a DIM-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an HLB of greater than 7, and one or more co-surfactants with an HLB equal to or less than 7. In certain aspects of the invention, the compositions disclosed herein show improved bioavailability.Type: GrantFiled: April 8, 2016Date of Patent: October 13, 2020Assignee: BioResponse, L.L.C.Inventors: Michael A. Zeligs, Irwin C. Jacobs
-
Patent number: 10441569Abstract: Disclosed herein are self-emulsifying compositions and formulations of Diindolylmethane (“DIM”) and certain derivatives of DIM, their uses and methods of making. In particular, the disclosed compositions comprise a DIM-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an HLB of greater than 7, and one or more co-surfactants with an HLB equal to or less than 7. In certain aspects of the invention, the compositions disclosed herein show improved bioavailability.Type: GrantFiled: December 15, 2017Date of Patent: October 15, 2019Assignee: BioResponse, L.L.C.Inventors: Michael A. Zeligs, Irwin C. Jacobs
-
Publication number: 20180280347Abstract: Disclosed herein are self-emulsifying compositions and formulations of Dimdolylmethane (“DIM”) and certain derivatives of DIM, their uses and methods of making. In particular, the disclosed compositions comprise a DIM-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an HLB of greater than 7, and one or more co-surfactants with an HLB equal to or less than 7. In certain aspects of the invention, the compositions disclosed herein show improved bioavailability.Type: ApplicationFiled: April 8, 2016Publication date: October 4, 2018Applicant: BioResponse, L.L.C.Inventors: Michael A. Zeligs, Irwin C. Jacobs
-
Publication number: 20180161308Abstract: Disclosed herein are self-emulsifying compositions and formulations of Diindolylmethane (“DIM”) and certain derivatives of DIM, their uses and methods of making. In particular, the disclosed compositions comprise a DIM-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an HLB of greater than 7, and one or more co-surfactants with an HLB equal to or less than 7. In certain aspects of the invention, the compositions disclosed herein show improved bioavailability.Type: ApplicationFiled: December 15, 2017Publication date: June 14, 2018Applicant: BioResponse, L.L.C.Inventors: Michael A. Zeligs, Irwin C. Jacobs
-
Patent number: 9918965Abstract: Disclosed herein are self-emulsifying compositions and formulations of Diindolylmethane (“DIM”) and certain derivatives of DIM, their uses and methods of making. In particular, the disclosed compositions comprise a DIM-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an HLB of greater than 7, and one or more co-surfactants with an HLB equal to or less than 7. In certain aspects of the invention, the compositions disclosed herein show improved bioavailability.Type: GrantFiled: April 8, 2016Date of Patent: March 20, 2018Assignee: BIORESPONSE, L.L.C.Inventors: Michael A. Zeligs, Irwin C. Jacobs
-
Patent number: 9663462Abstract: The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.Type: GrantFiled: December 18, 2015Date of Patent: May 30, 2017Assignee: BioResponse, L.L.C.Inventor: Michael A. Zeligs
-
Publication number: 20170014382Abstract: Disclosed herein are self-emulsifying compositions and formulations of Diindolylmethane (“DIM”) and certain derivatives of DIM, their uses and methods of making. In particular, the disclosed compositions comprise a DIM-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an HLB of greater than 7, and one or more co-surfactants with an HLB equal to or less than 7. In certain aspects of the invention, the compositions disclosed herein show improved bioavailability.Type: ApplicationFiled: April 8, 2016Publication date: January 19, 2017Applicant: BioResponse, L.L.C.Inventors: Michael A. Zeligs, Irwin C. Jacobs
-
Patent number: 9353058Abstract: The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.Type: GrantFiled: October 10, 2013Date of Patent: May 31, 2016Assignee: BioResponse, L.L.C.Inventor: Michael A. Zeligs
-
Publication number: 20160101083Abstract: The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.Type: ApplicationFiled: December 18, 2015Publication date: April 14, 2016Applicant: BioResponse, L.L.C.Inventor: Michael A. Zeligs
-
Patent number: 8552052Abstract: The present invention includes compositions and methods for the treatment and prevention of conditions associated with Respiratory Syncytial Virus (RSV) infection. RSV-associated conditions include acute infections in mammals, typically bronchiolitis and pneumonia, and post-infectious chronic respiratory conditions. In particular, the present invention describes new therapeutic and preventative uses for 3,3?-diindolylmethane (DIM), or a DIM-related indole, alone or in combination with an inhibitor of a membrane bound Epidermal Growth Factor Receptor (EGFR) inhibitors, to treat conditions associated with exposure to RSV.Type: GrantFiled: June 20, 2011Date of Patent: October 8, 2013Assignee: BioResponse, L.L.C.Inventor: Michael A. Zeligs
-
Patent number: 8236848Abstract: New methods and compositions are disclosed that comprise the phytochemical Diindolylmethane, alone or in combination with immune potentiating steroids. These methods and compositions are utilized to treat subjects suffering from common cutaneous warts (verrucae) and Human Papilloma Virus (HPV) related conditions of the oropharynx, larynx, genitalia, and uterine cervix.Type: GrantFiled: February 14, 2008Date of Patent: August 7, 2012Assignee: BioResponse, L.L.C.Inventor: Michael A. Zeligs
-
Patent number: 8080577Abstract: The present invention relates to compositions and methods for treating or preventing leiomyomas by administration of diindolylmethane and diindolylmethane-related indoles. The present invention also relates to compositions and methods for treating or preventing leiomyomas by administration of diindolylmethane in combination with an EGFR antagonist. The methods provide non-invasive treatments for leiomyomas.Type: GrantFiled: May 6, 2005Date of Patent: December 20, 2011Assignee: Bioresponse, L.L.C.Inventor: Michael A. Zeligs
-
Patent number: 7989486Abstract: The present invention includes compositions and methods for the treatment and prevention of conditions associated with Respiratory Syncytial Virus (RSV) infection. RSV-associated conditions include acute infections in mammals, typically bronchiolitis and pneumonia, and post-infectious chronic respiratory conditions. In particular, the present invention describes new therapeutic and preventative uses for 3,3?-diindolylmethane (DIM), or a DIM-related indole, alone or in combination with an inhibitor of a membrane bound Epidermal Growth Factor Receptor (EGFR) inhibitors, to treat conditions associated with exposure to RSV.Type: GrantFiled: December 30, 2005Date of Patent: August 2, 2011Assignee: Bioresponse, L.L.C.Inventor: Michael A. Zeligs
-
Patent number: 7384971Abstract: New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3?diindolylmethane (LTr-1), acceptable carriers and/or excipients. These compositions are administered to prevent or reduce symptoms associated with mastalgia, endometriosis and HPV-related conditions including cervical dysplasia.Type: GrantFiled: July 9, 2003Date of Patent: June 10, 2008Assignee: BioResponse L.L.C.Inventor: Michael A. Zeligs
-
Patent number: 7384972Abstract: New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3?diindolylmethane (LTR-1), acceptable carriers and/or excipients. These compositions are administered to prevent or reduce symptoms associated with mastalgia and endometriosis.Type: GrantFiled: January 26, 2004Date of Patent: June 10, 2008Assignee: BioResponse L.L.C.Inventor: Michael A. Zeligs
-
Patent number: 7348352Abstract: New methods and compositions are disclosed that comprise the phytochemical Diindolylmethane, alone or in combination with immune potentiating steroids. These methods and compositions are utilized to treat subjects suffering from common cutaneous warts (verrucae) and Human Papilloma Virus (HPV) related conditions of the oropharynx, larynx, genitalia, and uterine cervix.Type: GrantFiled: April 5, 2002Date of Patent: March 25, 2008Assignee: Bioresponse L.L.C.Inventor: Michael A. Zeligs
-
Patent number: 6534085Abstract: New dietary supplement compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3′ diindolylmethane (LTR-1), dietary supplement acceptable carriers and/or excipients. The use of these dietary supplement compositions facilitate weight loss as part of a nutritional system targeting release and metabolism of stored fat.Type: GrantFiled: September 23, 1999Date of Patent: March 18, 2003Assignee: BioResponse L.L.C.Inventor: Michael A. Zeligs
-
Patent number: 6416793Abstract: The present invention relates to spray dried hydrophobic phytochemical (i.e., yohimbine and ibogaine) compositions, a process for making such compositions and a method of using such compositions for, e.g., the promotion of weight loss. Typically, the hydrophobic dietary compositions of the present invention exhibit enhanced absorptivity when taken orally.Type: GrantFiled: July 11, 2000Date of Patent: July 9, 2002Assignee: BioResponse, L.L.C.Inventors: Michael A. Zeligs, Irwin C. Jacobs
-
Patent number: 6093706Abstract: The present invention relates to compositions and methods for the treatment of oxidative epithelial damage, for inadequate surfactant production in lung disorders, and for disorders of the urinary bladder epithelium. The compositions of the present invention comprise dehydroepiandrosterone and vitamin A derivatives.Type: GrantFiled: March 4, 1992Date of Patent: July 25, 2000Assignee: BioResponse, L.L.C.Inventor: Michael A. Zeligs